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Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation

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Third-generation EGFR tyrosine kinase inhibitors (TKIs), exemplified by osimertinib, have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer (NSCLC). Our previous work has identified ASK120067 as a novel third-generation EG... ...