Longjie Huangfu,Ruiying Li,Yamei Huang et al.
Longjie Huangfu et al.
The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological fun...
Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L [0.03%]
嗜酸细胞通过组织蛋白酶L促进肺基质破坏和肺气肿发生发展
Xia Xu,Tao Yu,Lingling Dong et al.
Xia Xu et al.
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement of eosinophils in the developm...
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment [0.03%]
让脑肿瘤饿死：组氨酸分解代谢重编程作为胶质母细胞瘤治疗的新靶点
Désirée Gül,Oliver H Krämer,Christoph Reinhardt
Désirée Gül
Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia [0.03%]
肌营养不良的新型致病轴： ectodysplasin A2受体-NF-κB诱导激酶在癌症恶病质中的作用
Janusz von Renesse,Peter Mirtschink
Janusz von Renesse
P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation [0.03%]
P21活化激酶1（PAK1）介导的细胞骨架重组促进SARS-CoV-2入侵和ACE2自噬降解
Ming Liu,Bingtai Lu,Yue Li et al.
Ming Liu et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant impact on healthcare systems and economies worldwide. The continuous emergence of new viral stra...
Drug-microbiota interactions: an emerging priority for precision medicine [0.03%]
药物与微生物组相互作用：精准医疗亟待重视的课题
Qing Zhao,Yao Chen,Weihua Huang et al.
Qing Zhao et al.
Individual variability in drug response (IVDR) can be a major cause of adverse drug reactions (ADRs) and prolonged therapy, resulting in a substantial health and economic burden. Despite extensive research in pharmacogenomics regarding the ...
SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals [0.03%]
SARS-CoV-2刺突特异性TFH细胞在感染和接种疫苗个体中的独特反应
Rongzhang He,Xingyu Zheng,Jian Zhang et al.
Rongzhang He et al.
Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (TFH) cells. However, the longevity and fu...
Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma [0.03%]
双特异免疫分子PD1-IL2v：胰腺导管腺癌治疗新策略
Yuan Gao,Liqing Yu,Hongming Miao
Yuan Gao
Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma [0.03%]
TP53突变型弥漫性大B细胞淋巴瘤中人类内源性逆转录病毒的表观遗传学治疗靶点作用
Ying Fang,Mu-Chen Zhang,Yang He et al.
Ying Fang et al.
TP53 mutation (TP53mut) occurs in 10-20% of diffuse large B-cell lymphoma (DLBCL) cases and serves as an unfavorable biomarker of DLBCL progression. It confers resistance to immunochemotherapy, high-dose chemotherapy, autologous stem cell t...