Mitochondrial dynamics in health and disease: mechanisms and potential targets [0.03%]
健康与疾病中的线粒体动力学：机制和潜在作用靶点
Wen Chen,Huakan Zhao,Yongsheng Li
Wen Chen
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature. These abilities allow them to effectively coordinate various cellular ...
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation [0.03%]
前列腺素受体活化通过增强葡萄糖氧化缓解压力超负荷诱导的心脏肥厚
Qian Liu,Guizhu Liu,Yujuan Zhuo et al.
Qian Liu et al.
Recent advances in targeting the "undruggable" proteins: from drug discovery to clinical trials [0.03%]
不可药物作用蛋白的药物研发新进展：从发现到临床试验
Xin Xie,Tingting Yu,Xiang Li et al.
Xin Xie et al.
Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere with using conventional drug design strategies. Targeting such undruggable targets has been ...
Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages [0.03%]
富马酸水合酶：炎症巨噬细胞中代谢调控的新节点
Aicha Jeridi,Theodore S Kapellos,Ali Önder Yildirim
Aicha Jeridi
Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth [0.03%]
关于一种针对NEMO/IKKβ的抑制小分子化合物的抑制剂抑制结直肠癌生长的文章的勘误通知书
Zhenlong Yu,Jian Gao,Xiaolei Zhang et al.
Zhenlong Yu et al.
Correction: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice [0.03%]
NPRC敲除通过抑制氧化应激、炎症和凋亡减轻动脉粥样硬化假说的更正：NPRC敲除通过抑制氧化应激、炎症和凋亡减轻Apoe基因敲除小鼠的动脉粥样硬化
Cheng Cheng,Jie Zhang,Xiaodong Li et al.
Cheng Cheng et al.
From Tpex to Tex: a journey through CD8+ T cell responses in cancer immunotherapy [0.03%]
从TPEX到TEX：肿瘤免疫治疗中CD8⁺T细胞反应的探索之旅
Julia M Messmer,Maike Effern,Michael Hölzel
Julia M Messmer
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing [0.03%]
利用碱基编辑技术生成IL2RG和RAG1失活的严重联合免疫缺陷猴
Xiao Zheng,Chunhui Huang,Yingqi Lin et al.
Xiao Zheng et al.
Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles. IL2RG is essenti...
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy [0.03%]
基于纳米抗体的双特异性T细胞衔接器(Nb-BiTE)：用于增强T细胞免疫治疗的新平台
Xiao-Mei Yang,Xuan-Dong Lin,Wei Shi et al.
Xiao-Mei Yang et al.
Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study [0.03%]
肠道微生物群与肺移植后的供体稳定性的相关性：一项前瞻性队列研究
Junqi Wu,Chongwu Li,Peigen Gao et al.
Junqi Wu et al.
Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. A prospective multicenter cohort of LTRs wa...