Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system
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The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoylation at cysteine-347 (C347), which is cru... ...