Feeding the vasculature with cruciferous vegetables: a secret for organ protection [0.03%]
用十字花科蔬菜滋养血管：器官保护的秘密
Priya Veluswamy,Jens Wippermann,Max Wacker
Priya Veluswamy
Protein translation: biological processes and therapeutic strategies for human diseases [0.03%]
蛋白质翻译：生物过程及人类疾病的治疗策略
Xuechao Jia,Xinyu He,Chuntian Huang et al.
Xuechao Jia et al.
Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. The deregulation of this process is increasingly recognized as a critical factor in the pathogenesis of various human d...
Gut microbiome regulates inflammation and insulin resistance: a novel therapeutic target to improve insulin sensitivity [0.03%]
肠道微生物群调节炎症和胰岛素抵抗：改善胰岛素敏感性的新治疗目标
Dilvin Semo,Holger Reinecke,Rinesh Godfrey
Dilvin Semo
Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment [0.03%]
纳米技术在对抗传染性和炎症性疾病前线的预防和治疗应用
Yujing Huang,Xiaohan Guo,Yi Wu et al.
Yujing Huang et al.
Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new ...
Targeted drug approvals in 2023: breakthroughs by the FDA and NMPA [0.03%]
2023年获批的靶向药物：FDA和NMPA的突破性进展
Lang Zheng,Wenjing Wang,Qiu Sun
Lang Zheng
TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway [0.03%]
TEA结构域转录因子1通过BRD4/Wnt4通路诱导心脏成纤维细胞重塑
Shuai Song,Xiaokai Zhang,Zihang Huang et al.
Shuai Song et al.
Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development and homeostasis. However, fibrob...
A novel alternative for pyrogen detection based on a transgenic cell line [0.03%]
基于转基因细胞系的新型内毒素检测方法研究
Qing He,Chuan-Fei Yu,Gang Wu et al.
Qing He et al.
Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals, traditional Chinese medicines and medical devices). It has become a goal to completely replace the in...
Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases [0.03%]
微生物群-肠-脑轴及其在神经退行性疾病中的治疗应用
Jian Sheng Loh,Wen Qi Mak,Li Kar Stella Tan et al.
Jian Sheng Loh et al.
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, d...
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes [0.03%]
Asialoglycoprotein receptor 1促进SARS-CoV-2感染人正常肝细胞
Xinyi Yang,Xu Zheng,Yuqi Zhu et al.
Xinyi Yang et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2) is t...
SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK [0.03%]
SARS-CoV-2刺突蛋白-ACE2相互作用通过p38 MAPK增加碳水化合物硫酸转移酶并减少N-乙酰半乳糖胺-4-硫酸酯酶
Sumit Bhattacharyya,Joanne K Tobacman
Sumit Bhattacharyya
Immunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase (Arylsulfatase B; ARSB). To explain these findings, hu...