Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions [0.03%]
宿主环孢菌素A通过与病毒刺突蛋白结合并稳定囊泡上的刺突蛋白来促进新冠病毒的感染
Xiangpeng Sheng,Fang Zhu,Hong Peng et al.
Xiangpeng Sheng et al.
Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages [0.03%]
小胶质细胞谷氨酰胺酶1介导慢性束缚应激诱导的类似抑郁的行为和突触损伤
Huili Chen,Shengyang Fu,Xiangyu Li et al.
Huili Chen et al.
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy [0.03%]
一种有效的苯腈类谷氨酰胺残基环化酶(QPCT)抑制剂的开发及其抗肿瘤功效
Lei Yu,Pengcheng Zhao,Yaoliang Sun et al.
Lei Yu et al.
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression [0.03%]
上皮细胞异常相互作用促进食管鳞状细胞癌的发生发展
Liping Chen,Shihao Zhu,Tianyuan Liu et al.
Liping Chen et al.
Epithelial-mesenchymal transition (EMT) and proliferation play important roles in epithelial cancer formation and progression, but what molecules and how they trigger EMT is largely unknown. Here we performed spatial transcriptomic and func...
Ting Fan,Mingna Zhang,Jingxian Yang et al.
Ting Fan et al.
With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies, cancer immunotherapy has undergone a profound transformation over the past decades. Recently, therapeutic cancer vaccines have shown p...
Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis [0.03%]
人类肌萎缩侧索硬化症的生物标志物：周边受体相互作用蛋白激酶1(RIPK1)和IL-8水平升高
Jun Wei,Min Li,Zhi Ye et al.
Jun Wei et al.
Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS. Primidone has been identified as an old drug ...
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy [0.03%]
甲基转移酶样蛋白3(METTL3)抑制增强抗肿瘤免疫：提高抗PD1治疗效果的新策略
Anna Brichkina,Roman Suezov,Magdalena Huber
Anna Brichkina
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases [0.03%]
靶向表观遗传和蛋白质翻译后修饰以调节铁死亡治疗疾病
Yumin Wang,Jing Hu,Shuang Wu et al.
Yumin Wang et al.
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug resistance...
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity [0.03%]
抗原诱导的嵌合抗原受体多聚化可增强对肿瘤细胞的毒性作用
Yan Sun,Xiu-Na Yang,Shuang-Shuang Yang et al.
Yan Sun et al.
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction across the cellular membrane. ...
Christopher C Udoye,Rudolf A Manz
Christopher C Udoye