A novel alternative for pyrogen detection based on a transgenic cell line [0.03%]
基于转基因细胞系的新型内毒素检测方法研究
Qing He,Chuan-Fei Yu,Gang Wu et al.
Qing He et al.
Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals, traditional Chinese medicines and medical devices). It has become a goal to completely replace the in...
Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases [0.03%]
微生物群-肠-脑轴及其在神经退行性疾病中的治疗应用
Jian Sheng Loh,Wen Qi Mak,Li Kar Stella Tan et al.
Jian Sheng Loh et al.
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, d...
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes [0.03%]
Asialoglycoprotein receptor 1促进SARS-CoV-2感染人正常肝细胞
Xinyi Yang,Xu Zheng,Yuqi Zhu et al.
Xinyi Yang et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2) is t...
SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK [0.03%]
SARS-CoV-2刺突蛋白-ACE2相互作用通过p38 MAPK增加碳水化合物硫酸转移酶并减少N-乙酰半乳糖胺-4-硫酸酯酶
Sumit Bhattacharyya,Joanne K Tobacman
Sumit Bhattacharyya
Immunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase (Arylsulfatase B; ARSB). To explain these findings, hu...
Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines [0.03%]
灭活疫苗接种成人异源加强接种重组新冠疫苗（Sf9细胞）的安全性、免疫原性和保护效力研究
Wenxin Luo,Jiadi Gan,Zhu Luo et al.
Wenxin Luo et al.
Vaccines have proven effective in protecting populations against COVID-19, including the recombinant COVID-19 vaccine (Sf9 cells), the first approved recombinant protein vaccine in China. In this positive-controlled trial with 85 adult part...
Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity [0.03%]
靶向SARS-CoV-2核衣壳蛋白的适体表现出潜在的广谱抗冠状病毒活性
Minghui Yang,Chunhui Li,Guoguo Ye et al.
Minghui Yang et al.
Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a broad-spectrum drug to combat HCo...
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy [0.03%]
对接蛋白6(DOK6)选择性对接神经营养信号转导以抑制周围神经病
Yan Guo,Pan Xiang,Xiaojiao Sun et al.
Yan Guo et al.
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits, and this process requires the proper recruitment of adaptor molecules to selectively activa...
Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma [0.03%]
营养素限制激活的Fra-2通过miR-15a下调的IGF1R促进胰管腺癌的发展
Gian Luca Rampioni Vinciguerra,Marina Capece,Luca Reggiani Bonetti et al.
Gian Luca Rampioni Vinciguerra et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability to...
Lulu Cui,Shu Li,Siman Wang et al.
Lulu Cui et al.
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological ...
Discovering deaminases using AlphaFold2: a strategy to search for tool proteins for gene editing [0.03%]
使用AlphaFold2发现脱氨酶：寻找基因编辑工具蛋白的策略
Yongye Huang,Jianxin Jiang,Min Wu
Yongye Huang