METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression [0.03%]
METTL14下调通过MyD88/NF-κB途径驱动S100A4+单核细胞来源的巨噬细胞促进MAFLD进展
Yue-Fan Wang,Wen-Li Zhang,Zhi-Xuan Li et al.
Yue-Fan Wang et al.
Without intervention, a considerable proportion of patients with metabolism-associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism-associated steatohepatitis (MASH), liver fibrosis, and even hepatocellular ...
Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma [0.03%]
新型PI3Kα/δ口服抑制剂TQB3525治疗复发/难治性滤泡淋巴瘤的II期研究
Huaqing Wang,Jifeng Feng,Yanyan Liu et al.
Huaqing Wang et al.
This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). This phase II study (ClinicalTrials.gov NCT04324879. ...
Ninel Azoitei,Sandra Heller,Alexander Kleger
Ninel Azoitei
Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3'-isoforms, displaying an altered expression in breast cancer [0.03%]
多聚腺苷酸特异性核糖核酸酶（PARN）生成和调节miR-125a-5p 3'同工型，并在乳腺癌中表达改变
Luisa Tomasello,Shoshanah M Holub,Giovanni Nigita et al.
Luisa Tomasello et al.
Chunling Wang,Junchao Xu,Xiaoyu Cheng et al.
Chunling Wang et al.
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various strategies aiming at regulating th...
Wei Deng,Linlin Bao,Zhiqi Song et al.
Wei Deng et al.
Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein, we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SAR...
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery [0.03%]
G蛋白偶联受体(GPCRs)：结构、机制及药物发现研究进展
Mingyang Zhang,Ting Chen,Xun Lu et al.
Mingyang Zhang et al.
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric...
Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity [0.03%]
硫胺素修饰的人多能干细胞源心肌细胞在空间微重力下的代谢重组
Xinglong Han,Lina Qu,Miao Yu et al.
Xinglong Han et al.
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore, the effects and mechanisms of microgravity on cardiac morphology, physiology, metabolism, and...
Chenglong Zhu,Sheng Xu,Ruoyu Jiang et al.
Chenglong Zhu et al.
The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This recently characterized class of pore-forming effector proteins is pivotal in orchestrating proce...
Shizhen Zhang,Qing Yu,Zhijian Li et al.
Shizhen Zhang et al.
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation, catalyzed by the enz...