Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity [0.03%]
黏附G蛋白偶联受体Latrophilin 1功能障碍增加肥胖发病风险
André Nguyen Dietzsch,Hadi Al-Hasani,Joachim Altschmied et al.
André Nguyen Dietzsch et al.
Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological inte...
Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis [0.03%]
黏附G蛋白偶联受体(aGPCR)的模块化结构及其可变剪接调控神经突触形成的作用机制研究
Tobias Langenhan
Tobias Langenhan
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection [0.03%]
FGF7可增强人胰岛类器官中的ACE2表达从而加剧SARS-CoV-2感染
Hao Meng,Zhiying Liao,Yanting Ji et al.
Hao Meng et al.
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19. In the current stud...
Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial [0.03%]
人脐带间充质干细胞治疗难治性免疫性血小板减少症的疗效和安全性：一项前瞻性、单组、Ⅰ期临床试验
Yunfei Chen,Yanmei Xu,Ying Chi et al.
Yunfei Chen et al.
Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising...
Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial [0.03%]
贝蒂氏结晶样角膜视网膜 dystrophy 患者基因替代疗法的开放性、单组、探索性试验
Jinyuan Wang,Jinlu Zhang,Shicheng Yu et al.
Jinyuan Wang et al.
Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2, which results in blindness in the working-age population, and there is currently no available treatment. Here, we report the results o...
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors [0.03%]
SRY-box转录因子9通过直接相互作用在肿瘤中触发YAP核进入
Hui Qian,Chen-Hong Ding,Fang Liu et al.
Hui Qian et al.
The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YAP are not fully understood. In ...
PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis [0.03%]
PBX/knotted 1同系物-homeobox-2(PKNOX2)是心肌纤维化的新调节因子
Liang Chen,Haotong Li,Xiaorui Liu et al.
Liang Chen et al.
Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically described because of the limitations i...
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma [0.03%]
一种新型工程IL-21受体使T细胞受体工程T细胞武装以对抗肝细胞癌
Wei Zhu,Zhiming Zhang,Jinzhang Chen et al.
Wei Zhu et al.
Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma (HCC) are urgently needed. The common cytokine receptor γ chain (γc) family cytokines such as IL-2, IL-7, IL-15 and IL-21 play fundamental role...
Ying Xia,Ming Sun,Hai Huang et al.
Ying Xia et al.
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug th...
The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial [0.03%]
一项单臂II期临床试验：PD-1抑制在高危肺磨玻璃结节病灶活性及免疫动态中的作用与机制探索
Bo Cheng,Caichen Li,Jianfu Li et al.
Bo Cheng et al.
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage ground-glass opacity (GGO) lesions ...