Signal transduction and targeted therapy. 2025 Feb 19;10(1):64. doi: 10.1038/s41392-025-02152-8 Q140.82024
Population-level analyses identify host and environmental variables influencing the vaginal microbiome
人群分析鉴别影响阴道微生物群的宿主和环境因素 翻译改进
Lang Qin 1 2 3 4 5, Tianyong Sun 6 7 8, Xiao Li 1 2 3 4 5, Shigang Zhao 9 10 11 12 13, Zheng Liu 1 2 3 4 5, Changlong Zhang 1 2 3 4 5, Congcong Jin 1 14, Yanqi Xu 1 15, Xuan Gao 1 2 3 4 5, Yongzhi Cao 1 2 3 4 5, Jiaojiao Wang 1 2 3 4 5, Ting Han 1 2 3 4 5, Lei Yan 1 2 3 4 5, Jialun Song 1 2 3 4 5, Fangfang Zhang 1 2 3 4 5, Feifei Liu 1 2 3 4 5, Yousheng Zhang 1 2 3 4 5, Yuzhen Huang 1 2 3 4 5, Yuping Song 1 2 3 4 5, Yanjun Liu 1 2 3 4 5, Jing Zhang 1 2 3 4 5, Xiuqing Zhang 1 2 3 4 5, Zhina Yao 1 2 3 4 5, Honglei Chen 1 2 3 4 5, Zhenzhen Zhang 1 2 3 4 5, Shengrui Zhao 1 2 3 4 5, Yuhan Feng 1 2 3 4 5, Ya-Nan Zhang 1 2 3 4 5, Qian Yu 1 2 3 4 5, Fang Cao 1 2 3 4 5, Lijuan Zhao 1 2 3 4 5, Lei Xie 1 2 3 4 5, Ling Geng 16 17 18, Qiang Feng 19 20 21 22, Han Zhao 23 24 25 26 27, Zi-Jiang Chen 28 29 30 31 32 33 34
作者单位 +展开
作者单位
1 State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.2 Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.3 Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.4 Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.5 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.6 Department of Human Microbiome, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.7 Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, 250012, Shandong, China.8 Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 250012, Shandong, China.9 State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China. zsg0108@126.com.10 Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China. zsg0108@126.com.11 Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China. zsg0108@126.com.12 Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China. zsg0108@126.com.13 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. zsg0108@126.com.14 Reproductive Medicine Center of the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.15 Linyi People's Hospital, Linyi, 276000, Shandong, China.16 State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China. gengling78@126.com.17 Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China. gengling78@126.com.18 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. gengling78@126.com.19 Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, 250012, Shandong, China. fengqiang@sdu.edu.cn.20 Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 250012, Shandong, China. fengqiang@sdu.edu.cn.21 Reproductive Medicine Center of the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. fengqiang@sdu.edu.cn.22 State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China. fengqiang@sdu.edu.cn.23 State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China. hanzh80@sdu.edu.cn.24 Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China. hanzh80@sdu.edu.cn.25 Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China. hanzh80@sdu.edu.cn.26 Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China. hanzh80@sdu.edu.cn.27 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. hanzh80@sdu.edu.cn.28 State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China. chenzijiang@hotmail.com.29 Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China. chenzijiang@hotmail.com.30 Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China. chenzijiang@hotmail.com.31 Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China. chenzijiang@hotmail.com.32 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. chenzijiang@hotmail.com.33 Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China. chenzijiang@hotmail.com.34 Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200135, China. chenzijiang@hotmail.com.
DOI: 10.1038/s41392-025-02152-8 PMID: 39966341
摘要 Ai翻译
The vaginal microbiome is critical for the reproductive health of women, yet the differential impacts exerted by the host and by ambient environmental variables on the vaginal microbiome remain largely unknown. Here, we conducted a comprehensive cross-sectional study of the relationships between the vaginal microbiome and 81 matched host and environmental variables across 6755 Chinese women. By 16S rRNA sequencing, we identified four core vaginal microbiota with a prevalence of over 90% and a total median abundance of 98.8%. Twenty-four variables, including physiology, lifestyle behaviors, gynecologic history, social and environmental information, were found associated with the microbiome composition, of which bacterial vaginosis (BV) showed the largest effect size. Age was among the strongest explanatory variables and the vaginal microbiome dynamically succeeded with increasing age, especially with a composition turning point at the age of 45. Our mediation analyses indicated that the effects of age on the microbiome could be mediated by variables such as parity number and lifestyles. We further classified the vaginal microbiomes of the population into 13 "Vagitypes". Women with Lactobacillus iners- and Lactobacillus jensenii-dominated Vagitypes had significantly higher live birth rate than those with Vagitype dominated by Fannyhessea vaginae (53.40%, 59.09% vs 21.43%; OR [95% CI]: 3.62 [1.12-14.87], 5.39 [1.27-27.36]; P = 0.031, P = 0.021). This study provides a comprehensive overview of the associations between identified variables and the vaginal microbiome, representing an important step toward understanding of environment-microbe-host interactions.
© 2025. The Author(s).
Keywords：population-level analyses; vaginal microbiome; host variables; environmental variables
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