A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury [0.03%]
A20通过抑制氧化的自身DNA介导的炎症在急性肾损伤中的作用研究
Hanwen Li,Yongyao Wu,Lisha Xiang et al.
Hanwen Li et al.
The ubiquitin-editing enzyme A20 is known to regulate inflammation and maintain homeostasis, but its role in self-DNA-mediated inflammation in acute kidney injury (AKI) is not well understood. Here, our study demonstrated that oxidized self...
Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy [0.03%]
结合超声波的仿生纳米药物用于癌症治疗
Juan Guo,Xueting Pan,Qingyuan Wu et al.
Juan Guo et al.
Addressing the critical biological barriers of targeted accumulation and deep tumor penetration remains essential for the clinical translation of nanomedicines. However, existing nanomedicines often face challenges during in vivo transporta...
Yang Yang,Bing Zhao,Yuanzhe Wang et al.
Yang Yang et al.
Diabetic neuropathy (DN) is a prevalent and debilitating complication of diabetes mellitus, significantly impacting patient quality of life and contributing to morbidity and mortality. Affecting approximately 50% of patients with diabetes, ...
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation [0.03%]
STING通过靶向GPX4促进其自噬降解从而加重心肌缺血再灌注铁死亡损伤
Xiaohong Wang,Tao Chen,Sizhe Chen et al.
Xiaohong Wang et al.
Despite advancements in interventional coronary reperfusion technologies following myocardial infarction, a notable portion of patients continue to experience elevated mortality rates as a result of myocardial ischemia-reperfusion (MI/R) in...
Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance [0.03%]
肿瘤免疫学：一种较短的IL18裂解产物促进癌症免疫监视
Emma Guilbaud,Lorenzo Galluzzi
Emma Guilbaud
Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry [0.03%]
新型胆盐摄取抑制剂雷帕韦强力阻断乙肝病毒入侵钠离子通道
Jia He,Haibo Yu,Kunling Song et al.
Jia He et al.
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin [0.03%]
α-中性糖苷酶C通过抑制血凝素的蛋白酶体依赖性降解促进流感病毒复制
Xinzhong Liao,Qian Xie,Minqi Liang et al.
Xinzhong Liao et al.
The H7N9 influenza virus poses a significant threat to human health, and the mechanism by which it infects humans remains incompletely understood. Our investigation has unveiled significant insights into the role of glucosidase alpha, neutr...
Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance [0.03%]
Ku80位点的乙酰化修饰转换为SUMO修饰促进DNA非同源末端连接及肿瘤细胞放疗抵抗作用
Hongling Zhao,Shanshan Gao,Yang Han et al.
Hongling Zhao et al.
Chemo-/radioresistance of malignant tumors hampers cancer control and increases patient mortality. Efficient repair of damaged DNA is critical for the maintenance of genomic integrity and fidelity of genetic information. In reverse, increas...
Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models [0.03%]
高效拮抗人肥大细胞和疾病模型中的MAS相关G蛋白偶联受体X2/B2的亚纳摩尔竞争性拮抗剂
Ghazl Al Hamwi,Mohamad Wessam Alnouri,Sven Verdonck et al.
Ghazl Al Hamwi et al.
The MAS-related G protein-coupled receptor-X2 (MRGPRX2), an orphan receptor expressed on mast cells (MCs), is upregulated upon inflammation and induces hypersensitivity and inflammatory diseases. In contrast to the large number of MRGPRX2 a...
IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy [0.03%]
IL-27：通过促进细胞毒性T淋巴细胞来增强癌症免疫治疗
Silvia Dusi,Vincenzo Bronte,Francesco De Sanctis
Silvia Dusi