Hearing difficulty is linked to Alzheimer's disease by common genetic vulnerability, not shared genetic architecture [0.03%]
听力困难与阿尔茨海默病通过共同的遗传易感性而非共享的遗传结构相关联
Fatin N Zainul Abidin,Helena R R Wells,Andre Altmann et al.
Fatin N Zainul Abidin et al.
Age-related hearing loss was recently established as the largest modifiable risk factor for Alzheimer's disease (AD), however, the reasons for this link remain unclear. We investigate shared underlying genetic associations using results fro...
Bcl-2-dependent autophagy disruption during aging impairs amino acid utilization that is restored by hochuekkito [0.03%]
百草枯诱导汤恢复老化过程中依赖Bcl-2的自噬中断及氨基酸利用失调的作用
Miwa Nahata,Sachiko Mogami,Hitomi Sekine et al.
Miwa Nahata et al.
Chronic undernutrition contributes to the increase in frailty observed among elderly adults, which is a pressing issue in the sector of health care for older people worldwide. Autophagy, an intracellular recycling system, is closely associa...
Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance [0.03%]
两大队列独立研究发现了两种与年龄相关的视觉反应时间表现变异潜在修饰因素
J S Talboom,M D De Both,M A Naymik et al.
J S Talboom et al.
To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svR...
Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans [0.03%]
秀丽杆线虫体内衰老和晚期糖基化终产物的非侵入式生物标记物自发荧光研究
Tomomi Komura,Mikihiro Yamanaka,Kohji Nishimura et al.
Tomomi Komura et al.
To assess the utility of autofluorescence as a noninvasive biomarker of senescence in Caenorhabditis elegans, we measured the autofluorescence of individual nematodes using spectrofluorometry. The fluorescence of each worm increased with ag...
Abnormal brain cholesterol homeostasis in Alzheimer's disease-a targeted metabolomic and transcriptomic study [0.03%]
阿尔茨海默病患者大脑胆固醇稳态异常-靶向代谢组学和转录组学研究
Vijay R Varma,H Büşra Lüleci,Anup M Oommen et al.
Vijay R Varma et al.
The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of...
Modeling transcriptomic age using knowledge-primed artificial neural networks [0.03%]
基于知识的神经网络建模转录组年龄
Nicholas Holzscheck,Cassandra Falckenhayn,Jörn Söhle et al.
Nicholas Holzscheck et al.
The development of 'age clocks', machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. However...
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart [0.03%]
衰老与心脏衰竭时兴奋收缩偶联的t系统及蛋白重建研究
Yankun Lyu,Vipin K Verma,Younjee Lee et al.
Yankun Lyu et al.
It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here,...
Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus [0.03%]
年龄对小鼠昼夜视觉系统及睡眠觉醒周期的影响
Dorela D Shuboni-Mulligan,Demarrius L Young Jr,Julianie De La Cruz Minyety et al.
Dorela D Shuboni-Mulligan et al.
Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep become disrupted as organisms a...
FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model [0.03%]
FKBP52过表达加速tau转基因小鼠海马依赖性记忆损伤
Marangelie Criado-Marrero,Niat T Gebru,Lauren A Gould et al.
Marangelie Criado-Marrero et al.
Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer's disease. Molecular chaperones with peptidyl-prolyl cis/trans isomerase (PPIase) activity are known to regulate these proce...
Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis [0.03%]
人类皮肤老化与表皮组蛋白变体H2A.J表达增加有关
Claudia E Rübe,Caroline Bäumert,Nadine Schuler et al.
Claudia E Rübe et al.
Cellular senescence is an irreversible growth arrest that occurs as a result of damaging stimuli, including DNA damage and/or telomere shortening. Here, we investigate histone variant H2A.J as a new biomarker to detect senescent cells durin...