Author Correction: Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease [0.03%]
作者更正：亨廷顿病YAC128模型大脑和骨骼肌中与年龄有关的线粒体改变
Kristina Bečanović,Muhammad Asghar,Izabella Gadawska et al.
Kristina Bečanović et al.
Published Erratum
NPJ aging and mechanisms of disease. 2021 Dec 7;7(1):27. DOI:10.1038/s41514-021-00080-9 2021
Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease [0.03%]
亨廷顿病YAC128模型大脑和骨骼肌中与年龄相关的线粒体改变
Kristina Bečanović,Muhammad Asghar,Izabella Gadawska et al.
Kristina Bečanović et al.
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in Huntington's disease (HD) and aging. In the present study, we used the YAC128 murine model of HD to examine the effects of mutant huntingtin on mitocho...
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs [0.03%]
烟酸核糖改善Atm-/-和老年小鼠造血干细胞的淋巴细胞分化潜能
Le Zong,Mayuri Tanaka-Yano,Bongsoo Park et al.
Le Zong et al.
NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem c...
Assessing the cognitive status of Drosophila by the value-based feeding decision [0.03%]
通过基于价值的喂食决定评估果蝇的认知状态
Chih-Chieh Yu,Ferng-Chang Chang,Yong-Huei Hong et al.
Chih-Chieh Yu et al.
Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploi...
Li-Chun Cho,Chih-Chieh Yu,Chih-Fei Kao
Li-Chun Cho
Lifespan is modulated at distinct levels by multiple factors, including genetic backgrounds, the environment, behavior traits, metabolic status, and more interestingly, sensory perceptions. However, the effects of social perception between ...
Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents [0.03%]
拟步目和树鼠目的癌症抗性可能是基因组重排的趋同进化导致的
Yachna Jain,Keerthivasan Raanin Chandradoss,Anjoom A V et al.
Yachna Jain et al.
The rodents of hystricomorpha and sciuromorpha suborders exhibit remarkably lower incidence of cancer. The underlying genetic basis remains obscure. We report a convergent evolutionary split of human 3p21.31, a locus hosting a large number ...
Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice [0.03%]
人中的ADROPIN与年龄相关的神经系统疾病相关并与小鼠老化认知功能改善有关
Subhashis Banerjee,Sarbani Ghoshal,Clemence Girardet et al.
Subhashis Banerjee et al.
The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed in astrocytes and peaks during critical postnatal periods of brain development. Gene enric...
The killifish visual system as an in vivo model to study brain aging and rejuvenation [0.03%]
鳉鱼视觉系统作为研究大脑衰老和再生的活体模型
Sophie Vanhunsel,Steven Bergmans,An Beckers et al.
Sophie Vanhunsel et al.
Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly. Age-associated neuropath...
Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia [0.03%]
辛伐他汀治疗可减轻慢性高胆固醇相关的小鼠脑单核细胞浸润和记忆缺损
Nicholas Don-Doncow,Lotte Vanherle,Frank Matthes et al.
Nicholas Don-Doncow et al.
Evidence associates cardiovascular risk factors with unfavorable systemic and neuro-inflammation and cognitive decline in the elderly. Cardiovascular therapeutics (e.g., statins and anti-hypertensives) possess immune-modulatory functions in...
Mohammed R Shaker,Julio Aguado,Harman Kaur Chaggar et al.
Mohammed R Shaker et al.
Aging is a major risk factor for many neurodegenerative diseases. Klotho (KL) is a glycosylated transmembrane protein that is expressed in the choroid plexus and neurons of the brain. KL exerts potent anti-aging effects on multiple cell typ...