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FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model

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Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer's disease. Molecular chaperones with peptidyl-prolyl cis/trans isomerase (PPIase) activity are known to regulate these processes. Previously, in... ...