Zinc silicate modulates bone substitute degradation following macrophage activation via the JAK/STAT pathway and expedites the initiation of bone repair: in vitro and in vivo studies [0.03%]
一种硅酸锌生物材料通过活化巨噬细胞调控仿生骨修复材料的降解并加速骨修复：体内外研究
Jingdi Chen,Xiaotian Hao,Chunxing Xian et al.
Jingdi Chen et al.
Repairing segmental bone defects remains difficult because conventional bone substitutes rarely integrate immunomodulation with efficient tissue regeneration. To address this limitation, zinc silicate/collagen/hydroxyapatite (ZCH) composite...
A novel polyester-drug nanoconjugate with subtype selectivity for high efficacy against PSMA-positive prostate cancer [0.03%]
一种新型的聚酯-药物纳米缀合物具有亚型选择性可高效用于PSMA阳性前列腺癌
Shiwei Guo,Xiyan Xu,Guobing Li et al.
Shiwei Guo et al.
Prostate-specific membrane antigen (PSMA) positive prostate cancer (PCa) accounts for 80-90% cases. Docetaxel (DTX) is a first-line chemotherapy drug for metastatic castration resistant prostate cancer (mCRPC) and has exhibited promising ef...
M1 macrophage-targeted engineered ginseng stems and leaves-derived extracellular vesicles delivery system for alleviating rheumatoid arthritis [0.03%]
针对M1型巨噬细胞的工程化人参茎叶外泌体递送系统用于缓解类风湿性关节炎
Chuanjie Zhang,Yingjie Wang,Xiaoyu Jiang et al.
Chuanjie Zhang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, oxidative stress damage and joint destruction. Current treatments often face challenges including limited targeting efficacy and sy...
Injectable platelet-rich plasma-based hydrogels: a controlled release platform for growth factors and cardiac regeneration post-myocardial infarction [0.03%]
可注射的富含血小板的血浆基水凝胶：心肌梗死后生长因子控制释放及心脏再生平台
Yaqiang Shi,Yaqin Liu,Xiaoyu Bai et al.
Yaqiang Shi et al.
Myocardial infarction (MI) is a leading cause of high global cardiovascular mortality and disability. Platelet-rich plasma (PRP), as a widely available autologous biological product rich in various growth factors, holds significant potentia...
Manganese-doped nano-hydroxyapatite enhances CF/PEEK osseointegration via immunomodulation-osteogenesis coupling [0.03%]
锰掺杂纳米羟基磷灰石通过免疫调节-骨生成偶联增强CF/PEEK骨整合能力
Jiajun Liu,Zhenghao Li,Xuening Chen et al.
Jiajun Liu et al.
Carbon fiber-reinforced polyetheretherketone (CF/PEEK) exhibits great application potential in repairing bone defects, particularly in large segmental defects at load-bearing sites, due to its advantages of bone-matching mechanical properti...
Hybrid hydrogel system integrating thermoresponsive microspheres and KGN-loaded nanofibers enables efficient cartilage matrix regeneration [0.03%]
集成了温敏微球和KGN载药纳米纤维的杂化水凝胶系统可实现高效的软骨基质再生
Jian Huang,Chen Tang,Ye Wu et al.
Jian Huang et al.
Articular cartilage has limited self-repair ability, and effective therapies for defects remain challenging. Injectable hydrogels are attractive for cartilage tissue engineering as they can fill irregular defects and mimic the native extrac...
A 'frost formation'-inspired near-infrared-responsive nitric oxide-releasing hydrogel for enhancing fat graft survival [0.03%]
一种受“霜形成”启发的近红外响应性一氧化氮释放型水凝胶促进脂肪移植成活
Yanglong Zhu,Yatian Wei,Zixun Lan et al.
Yanglong Zhu et al.
Soft tissue defects represent a major challenge in plastic surgery, for which autologous fat grafting remains the standard treatment. However, in the early post-transplant period, the grafted fat tissue undergoes ischemia and hypoxia, leadi...
Cell membrane-coated nanoparticles against non-alcoholic fatty liver disease via regulating endoplasmic reticulum stress [0.03%]
通过调节内质网应激治疗非酒精性脂肪肝病的细胞膜涂层纳米颗粒
Weiwei Li,Long Yang,Jiao Lu et al.
Weiwei Li et al.
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health challenge, yet the available therapeutic options remain limited. Evidence suggests that NAFLD may advance to more serious conditions, including steatohepatitis or cirr...
Recombinant humanized type III collagen improves ovarian function via ITGA2-mediated mitochondrial function restoration in granulosa cells and extracellular matrix remodeling [0.03%]
人源化重组III型胶原蛋白通过ITGA2介导的颗粒细胞线粒体功能恢复和重塑卵泡微环境改善卵巢功能
Quan Wei,Shuaibin Liu,Zhiyong Dong et al.
Quan Wei et al.
Ovarian aging is characterized by depletion of the follicular reserve. The extracellular matrix (ECM) provides the essential microenvironmental niche for follicles, and aged-related alterations in ECM composition may adversely affect follic...
Zonally patterned demineralized bone matrix-meniscus ECM composite scaffold directing region-specific fibrochondrogenic and angiogenic responses [0.03%]
具有区域特异性软骨发生和血管生成应答的带状分布脱矿骨基质-半月板基质复合支架
Hee-Woong Yun,Chae-Won Yun,Mi Jeong Kim et al.
Hee-Woong Yun et al.
The human meniscus is a zonal fibrocartilage characterized by inner-outer gradients in matrix composition and outer vascularity, essential for mechanical function and tissue integration. However, these hierarchical features are rarely repro...