Migration of co-cultured endothelial and smooth muscle cells on material surfaces [0.03%]
共培养的内皮细胞和平滑肌细胞在材料表面的迁移行为研究
Runjia Shen,Yanshuang Zhang,Ziyue Zhang et al.
Runjia Shen et al.
Surface endothelialization of a medical device after implantation into the cardiovascular system depends upon competitive migration between endothelial cells (ECs) and smooth muscle cells (SMCs). While both cell types have been extensively ...
Development and translation of biodegradable metal stents: from heart to brain [0.03%]
可降解金属支架的研发与转化：从心脏到血管中枢神经系统肿瘤治疗中的应用
Xiaofeng Cao,Guanjun Chen,Yuchen Fan et al.
Xiaofeng Cao et al.
Biodegradable metal stents offer a promising approach for vascular intervention by providing temporary mechanical support and subsequently degrading once healing is complete. While significant progress has been made in cardiovascular applic...
Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions [0.03%]
基于协同作用的纳米复合水凝胶促进感染条件下的组织再生
Kailing Yu,Jia Zhong,Yilin Ma et al.
Kailing Yu et al.
Impaired tissue regeneration, rather than mere bacterial colonization, represents the core pathological challenge in infected wounds, where persistent infection, biofilm formation and inflammatory dysregulation collectively disrupt the heal...
Integrated platform for EV separation and controlled release based on gelatin microspheres for diabetic wound treatment [0.03%]
一种基于明胶微球的集成平台用于糖尿病伤口治疗中的EV分离和可控释放
Yiqing Zhang,Qilin Huang,Hao Meng et al.
Yiqing Zhang et al.
Diabetic wounds exhibit impaired healing owing to multiple pathological factors and current treatment options remain limited, underscoring the urgent need for novel therapeutic strategies. Extracellular vesicles (EVs) derived from mesenchym...
Zinc silicate modulates bone substitute degradation following macrophage activation via the JAK/STAT pathway and expedites the initiation of bone repair: in vitro and in vivo studies [0.03%]
一种硅酸锌生物材料通过活化巨噬细胞调控仿生骨修复材料的降解并加速骨修复：体内外研究
Jingdi Chen,Xiaotian Hao,Chunxing Xian et al.
Jingdi Chen et al.
Repairing segmental bone defects remains difficult because conventional bone substitutes rarely integrate immunomodulation with efficient tissue regeneration. To address this limitation, zinc silicate/collagen/hydroxyapatite (ZCH) composite...
A novel polyester-drug nanoconjugate with subtype selectivity for high efficacy against PSMA-positive prostate cancer [0.03%]
一种新型的聚酯-药物纳米缀合物具有亚型选择性可高效用于PSMA阳性前列腺癌
Shiwei Guo,Xiyan Xu,Guobing Li et al.
Shiwei Guo et al.
Prostate-specific membrane antigen (PSMA) positive prostate cancer (PCa) accounts for 80-90% cases. Docetaxel (DTX) is a first-line chemotherapy drug for metastatic castration resistant prostate cancer (mCRPC) and has exhibited promising ef...
M1 macrophage-targeted engineered ginseng stems and leaves-derived extracellular vesicles delivery system for alleviating rheumatoid arthritis [0.03%]
针对M1型巨噬细胞的工程化人参茎叶外泌体递送系统用于缓解类风湿性关节炎
Chuanjie Zhang,Yingjie Wang,Xiaoyu Jiang et al.
Chuanjie Zhang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, oxidative stress damage and joint destruction. Current treatments often face challenges including limited targeting efficacy and sy...
Injectable platelet-rich plasma-based hydrogels: a controlled release platform for growth factors and cardiac regeneration post-myocardial infarction [0.03%]
可注射的富含血小板的血浆基水凝胶：心肌梗死后生长因子控制释放及心脏再生平台
Yaqiang Shi,Yaqin Liu,Xiaoyu Bai et al.
Yaqiang Shi et al.
Myocardial infarction (MI) is a leading cause of high global cardiovascular mortality and disability. Platelet-rich plasma (PRP), as a widely available autologous biological product rich in various growth factors, holds significant potentia...
Manganese-doped nano-hydroxyapatite enhances CF/PEEK osseointegration via immunomodulation-osteogenesis coupling [0.03%]
锰掺杂纳米羟基磷灰石通过免疫调节-骨生成偶联增强CF/PEEK骨整合能力
Jiajun Liu,Zhenghao Li,Xuening Chen et al.
Jiajun Liu et al.
Carbon fiber-reinforced polyetheretherketone (CF/PEEK) exhibits great application potential in repairing bone defects, particularly in large segmental defects at load-bearing sites, due to its advantages of bone-matching mechanical properti...
Hybrid hydrogel system integrating thermoresponsive microspheres and KGN-loaded nanofibers enables efficient cartilage matrix regeneration [0.03%]
集成了温敏微球和KGN载药纳米纤维的杂化水凝胶系统可实现高效的软骨基质再生
Jian Huang,Chen Tang,Ye Wu et al.
Jian Huang et al.
Articular cartilage has limited self-repair ability, and effective therapies for defects remain challenging. Injectable hydrogels are attractive for cartilage tissue engineering as they can fill irregular defects and mimic the native extrac...