Ascorbic acid 2-phosphate-releasing poly-l-lactide-co-epsilon-caprolactone membranes enhance tissue regeneration: first in vivo insights for pelvic organ prolapse [0.03%]
抗坏血酸2-磷酸释放型聚乳酸-ε-己内酯膜促进组织再生：盆腔器官脱垂在体研究的初步观察
Alma Kurki,Markus Hannula,Susanna Miettinen et al.
Alma Kurki et al.
Pelvic organ prolapse (POP) significantly impacts women's health and quality of life. There is a critical need for alternative biomaterials for surgical POP repair, driven by complications associated with conventional non-absorbable vaginal...
Integrating graph convolutional networks with large language models for structured biomedical material knowledge representation [0.03%]
图卷积网络与大型语言模型结合表示结构化生物医学材料知识
Mufei Li,Yan Zhuang,Yao Hou et al.
Mufei Li et al.
Automated literature mining is key to building structured biomedical materials databases, yet current methods struggle with large publication volumes, complex entity relations and domain-specific terminology. We propose a hierarchical natur...
TiO2 nanotubes regulate osteo-adipogenic balance through SREBP1 to determine the fate of bone marrow mesenchymal stem cells [0.03%]
TiO₂纳米管通过SREBP1调节骨髓间充质干细胞成软骨/成脂肪命运决定的平衡关系
Xiaoxiao Wang,Qiqi Si,Na Yang et al.
Xiaoxiao Wang et al.
Titanium-based materials are commonly utilized in bone tissue repair due to their exceptional physical and chemical properties. Surface modification of titanium dioxide (TiO2) nanotubes effectively modulates cellular osteo-adipogenic balanc...
ROS-triggered hydrophilicity switching synergizes with pH-responsive nanocarriers for therapy of diabetic wound [0.03%]
ROS触发的亲水性切换与pH响应型纳米载体协同治疗糖尿病伤口
Bin Yin,Yueying Fan,Jinfu Li et al.
Bin Yin et al.
Chronic diabetic wounds are notoriously difficult to heal due to the self-perpetuating cycle of persistent inflammation and oxidative stress, while current therapies are limited by single-action mechanisms and inefficient drug delivery. Thi...
Tissue-engineered liver using 3D-printed silk fibroin scaffolds loaded with stem cells for the treatment of acute liver injury [0.03%]
负载干细胞的三维打印丝素蛋白支架工程肝脏用于急性肝损伤治疗
Xiaonan Shi,Xuan Wu,Daxu Zhang et al.
Xiaonan Shi et al.
Liver tissue engineering offers a promising therapeutic strategy for acute liver injury (ALI). Although traditional biomaterial scaffolds exhibit favorable biocompatibility, they still face limitations in the construction of precise structu...
Fibroblast-loaded carboxymethyl chitosan-aldehyde hyaluronic acid injectable hydrogel for scleral remodelling to prevent development of myopia [0.03%]
载成纤维细胞的羧甲基壳聚糖-醛化透明质酸注射型水凝胶用于巩膜重塑以预防近视发展
Jingwen Hui,Kexin Tang,Yuejun Zhou et al.
Jingwen Hui et al.
High myopia severely threatens the visual health of adolescents, with pathological features of decreased collagen aggregation and scleral thinning, ultimately leading to axial elongation on preretinal imaging. Fibroblasts play crucial roles...
Protein conformational transition microenvironment in silk fibroin hydrogels: proliferation and chondrogenesis of encapsulated stem cells [0.03%]
丝素水凝胶中的蛋白质构象转变微环境：封装干细胞的增殖和软骨发生性
Weikun Zhao,Guolong Cai,Jiayao Qian et al.
Weikun Zhao et al.
Chemically crosslinked silk fibroin (SF) hydrogels exhibit excellent extracellular matrix-mimicking features and tunable mechanical characteristics, making them highly promising for 3D cell culture and tissue engineering. However, the prote...
Three-dimensional-printed triply periodic minimal surface scaffolds via digital light processing for enhanced osteogenesis [0.03%]
用于改善成骨的基于数字光处理技术的三维打印三重周期性极小曲面支架
Weilong Zou,Xiyuan Han,Qiyuan Dai et al.
Weilong Zou et al.
Natural bone is a naturally mineralized material with a nonhomogeneous porous structure, which is difficult to construct using conventional manufacturing methods. Triply periodic minimal surfaces (TPMS) have emerged as an excellent solution...
Promoting spinal cord injury repair by using ZnO@MOFs nanozymes functionalized hydrogel through the ROS microenvironment regulating pathway [0.03%]
基于ROS微环境调节途径的ZnO@MOFs纳米酶功能水凝胶促进脊髓损伤修复
Jiaxin Ding,Binbin Gao,Zelin Sang et al.
Jiaxin Ding et al.
Spinal cord injury (SCI) is a kind of health problem characterized by oxidative stress and neuronal apoptosis, which pose major challenges to the recovery of patients. Recently, the application of photothermal nanotechnology in medicine has...
Aligned nanofibers in biomimetic periosteal extracellular matrix/poly(ε-caprolactone) membranes enhance bone regeneration via the ITGB1/PI3K/AKT pathway [0.03%]
仿生骨膜细胞外基质/聚-ɛ-己内酯膜中取向纳米纤维通过ITGB1 / PI3K / AKT途径增强骨再生
Zhuohao Wen,Shuyi Li,Huiguo Qiu et al.
Zhuohao Wen et al.
Periosteum plays an indispensable role in bone regeneration by providing osteogenic and angiogenic cues essential for tissue repair. In cases of severe bone defects or nonunion, autologous vascularized periosteum transplantation remains a h...