Elucidating the selection mechanisms in context-dependent computation through low-rank neural network modeling [0.03%]
基于低秩神经网络建模的上下文依赖计算中选择机制的研究
Yiteng Zhang,Jianfeng Feng,Bin Min
Yiteng Zhang
Humans and animals exhibit a remarkable ability to selectively filter out irrelevant information based on context. However, the neural mechanisms underlying this context-dependent selection process remain elusive. Recently, the issue of dis...
The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA [0.03%]
人巨细胞病毒编码的pUS28通过靶向CIITA来对抗CD4+T细胞的作用
Fabienne Maassen,Vu Thuy Khanh Le-Trilling,Luisa Betke et al.
Fabienne Maassen et al.
Human cytomegalovirus (HCMV) is a relevant pathogen, especially for individuals with impaired immunity. Harnessing potent immune antagonists, HCMV circumvents sterile immunity. Given that HCMV prevents the upregulation of human leukocyte an...
Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome [0.03%]
脑皮层联结组的结构拓扑与可塑性相互作用解释其功能起源
András Ecker,Daniela Egas Santander,Marwan Abdellah et al.
András Ecker et al.
Synaptic plasticity underlies the brain's ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordina...
C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice [0.03%]
C-C趋化因子受体4缺乏通过促进单核细胞向淋巴结迁移加重小鼠早期动脉粥样硬化病变
Toru Tanaka,Naoto Sasaki,Aga Krisnanda et al.
Toru Tanaka et al.
Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T...
Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex [0.03%]
利用磁共振成像技术测定膜电位调节离子溶液的响应：细胞培养和大鼠皮层中的研究
Kyeongseon Min,Sungkwon Chung,Seung-Kyun Lee et al.
Kyeongseon Min et al.
Membrane potential plays a crucial role in various cellular functions. However, existing techniques for measuring membrane potential are often invasive or have limited recording depth. In contrast, MRI offers noninvasive imaging with desira...
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides [0.03%]
异质性外排泵表达构成了对抗菌肽的表型抗性基础
Ka Kiu Lee,Urszula Łapińska,Giulia Tolle et al.
Ka Kiu Lee et al.
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need to develop novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to convent...
Intrinsic dynamic shapes responses to external stimulation in the human brain [0.03%]
人脑对刺激的内在动态形态响应研究
Maximilian Nentwich,Marcin Leszczynski,Charles E Schroeder et al.
Maximilian Nentwich et al.
Sensory stimulation of the brain reverberates in its recurrent neural networks. However, current computational models of brain activity do not separate immediate sensory responses from this intrinsic dynamic. We apply a vector-autoregressiv...
Chrissy M Leopold Wager,Larry S Schlesinger
Chrissy M Leopold Wager
Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon. ...
Editorial
eLife. 2025 Jul 3:14:e107787. DOI:10.7554/eLife.107787 2025
Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22 [0.03%]
LGI1-ADAM22癫痫相关配体受体复合物异源六聚体组装的结构洞察
Takayuki Yamaguchi,Kei Okatsu,Masato Kubota et al.
Takayuki Yamaguchi et al.
Leucine-rich glioma-inactivated 1 protein (LGI1) is a secreted neuronal protein consisting of the N-terminal leucine-rich repeat (LRR) and C-terminal epitempin-repeat (EPTP) domains. LGI1 is linked to epilepsy, a neurological disorder that ...
Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading [0.03%]
PCBP2通过干扰SYNCRIP依赖的miRNA装运来调控miRNA分拣进入外泌体的负向调节作用
Francesco Marocco,Sabrina Garbo,Claudia Montaldo et al.
Francesco Marocco et al.
While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still l...