Synchronous ensembles of hippocampal CA1 pyramidal neurons during novel exploration [0.03%]
新颖环境探索过程中海马CA1区锥体神经元的同步簇群活动
En-Li Chen,Tsai-Wen Chen,Eric R Schreiter et al.
En-Li Chen et al.
Synchronous neuronal ensembles play a pivotal role in the consolidation of long-term memory in the hippocampus. However, their organization during the acquisition of spatial memory remains less clear. In this study, we used neuronal populat...
Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness [0.03%]
经颅直流电刺激可调节灵长类动物不同意识状态下的脑动力学变化
Guylaine Hoffner,Pablo Castro,Lynn Uhrig et al.
Guylaine Hoffner et al.
The resting primate brain is traversed by spontaneous functional connectivity patterns that show striking differences between conscious and unconscious states. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory t...
KDM5 demethylases suppress R-loop-mediated 'viral mimicry' and DNA damage in breast cancer cells [0.03%]
KDM5去甲基酶通过抑制R-loop介导的“病毒模因”和DNA损伤来促进乳腺癌细胞生长
Lena Lau,Kurt Henderson,Ahu Turkoz et al.
Lena Lau et al.
Tumors with low expression of interferon-stimulated genes (ISG) and antigen presentation (AP) genes respond relatively poorly to current immunotherapies. One of the early hallmarks of cancer is DNA hypomethylation in genomic repeat regions ...
Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates [0.03%]
视皮层和枕叶皮层之间的共同功能组织及其结构和分子影像特征
Gianpaolo Antonio Basile,Augusto Ielo,Lilla Bonanno et al.
Gianpaolo Antonio Basile et al.
The pulvinar, the largest thalamic nucleus, is a highly interconnected structure supporting perception, visuospatial attention, and emotional processing. Such a central role relies on a precise topographical organization reflected in anatom...
Maria Puchik,Igor Kagan
Maria Puchik
A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates. ...
Editorial
eLife. 2025 Oct 13:14:e109193. DOI:10.7554/eLife.109193 2025
Age and learning shapes sound representations in auditory cortex during adolescence [0.03%]
年龄和学习在青少年期塑造听觉皮层中的声音表征
Benedikt Praegel,Feng Chen,Adria Dym et al.
Benedikt Praegel et al.
Adolescence is a developmental period characterized by heightened plasticity. Yet, how ongoing development affects sensory processing and cognitive function is unclear. We investigated how adolescent (postnatal day 20-42) and adult (postnat...
Nikolaos Nirakis,Sofia Dimothyra,Eleftheria Karadima et al.
Nikolaos Nirakis et al.
Innate immune cells possess memory-like properties. Exposure to infections or sterile inflammation can prime them, leading to either exacerbated inflammatory responses, a process called trained immunity, or reduced responsiveness to pro-inf...
Long Wang,Christo Morison,Weini Huang
Long Wang
The immune system is one of the first lines of defence against cancer. When effector cells attempt to suppress tumour, cancer cells can evolve methods of escape or inhibition. Knowledge of this coevolutionary system can help to understand t...
Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL [0.03%]
Wnt诱导FZD5/8内吞及降解以及RSPO-ZNRF3/RNF43和DVL的参与
Dong Luo,Jing Zheng,Shuning Lv et al.
Dong Luo et al.
Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 promote the endocy...
Forecasting the spatial spread of an Ebola epidemic in real time: Comparing predictions of mathematical models and experts [0.03%]
预测埃博拉疫情空间传播的模型与专家判断之比较分析
James D Munday,Alicia Rosello,John Edmunds et al.
James D Munday et al.
Background: Ebola virus disease outbreaks can often be controlled, but require rapid response efforts frequently with profound operational complexities. Mathematical models can be used to support response planning, but it...
Comparative Study
eLife. 2025 Oct 10:13:RP98005. DOI:10.7554/eLife.98005 2025