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The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

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Human cytomegalovirus (HCMV) is a relevant pathogen, especially for individuals with impaired immunity. Harnessing potent immune antagonists, HCMV circumvents sterile immunity. Given that HCMV prevents the upregulation of human leukocyte antigen (HLA)-DP and H... ...