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Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22

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Leucine-rich glioma-inactivated 1 protein (LGI1) is a secreted neuronal protein consisting of the N-terminal leucine-rich repeat (LRR) and C-terminal epitempin-repeat (EPTP) domains. LGI1 is linked to epilepsy, a neurological disorder that can be caused by gen... ...