Association between miRNA expression profiles and polymorphisms of dihydropyrimidine dehydrogenase drug-metabolizing gene in patients with colorectal cancer receiving 5-fluorouracil [0.03%]
尿嘧啶二聚体脱氢酶代谢基因多态性与结直肠癌氟尿嘧啶治疗患者的微小核糖核酸表达谱关联分析
Phatchariya Phannasil,Phichai Chansriwong,Ekaphop Sirachainan et al.
Phatchariya Phannasil et al.
5-Fluorouracil (5-FU) is widely used for colorectal cancer (CRC) treatment. Its administration is challenged by wide variability in patient toxicity. Genetic polymorphisms in dihydropyrimidine dehydrogenase (DYPD) and circulating microRNAs ...
Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke [0.03%]
血管危险因素对卒中患者血管内机械取栓效果的影响
Walaa A Aldarwish,Shahid Bashir,Eman Mohammed Ali et al.
Walaa A Aldarwish et al.
Endovascular mechanical thrombectomy (MT) is a recommended treatment for acute ischemic stroke due to large vessel occlusion (LVO). The objective of the present study was to evaluate the impact of vascular risk factors on the outcome of MT ...
Puerariae radix flavones induce apoptosis in bladder cancer T24 cells via the FAS/TNFR1 pathway: A potential therapeutic candidate [0.03%]
葛根异黄酮通过FAS/TNFR1途径诱导膀胱癌T24细胞凋亡：一种潜在的治疗候选药物
Jing Dong,Yupeng Guo,Tao Ji et al.
Jing Dong et al.
Puerariae radix flavones (PRFs), bioactive components derived from the Pueraria lobata plant, exhibit anti-inflammatory and anti-tumor properties. However, their therapeutic potential for bladder cancer remains poorly understood. The presen...
Intraoperative electrocorticography in focal drug-resistant epilepsy: A 10-year retrospective single-center study [0.03%]
难治性局灶性癫痫术中超脑电图的10年单中心回顾性研究
Amani Alshahrani,Ziyad Mohammed Althani,Raidah Al-Baradie et al.
Amani Alshahrani et al.
Intraoperative electrocorticography (ECoG) represents a crucial tool for improving seizure outcomes during epilepsy surgeries by assisting in localization of the epileptogenic zones. There is a shortage of information in the literature rega...
Impact of the ATM/Chk2 pathway and cell cycle phase on radiation-induced senescence in A549 human lung cancer cells [0.03%]
ATM/Chk2通路及细胞周期阶段对A549人肺癌细胞辐射诱导衰老的影响
Kota Sato,Hironori Yoshino,Yoshiaki Sato et al.
Kota Sato et al.
Cell senescence is a state of stable proliferation arrest characterized by morphological changes and high senescence-associated β-galactosidase (SA-β-gal) activity. Inducing senescence in cancer cells is beneficial for cancer therapy due ...
Conserved methylation signature accurately predicts heavily irradiated CNS tumour with perplexing histopathology: A case report [0.03%]
保守的甲基化标志准确预测出具有令人困惑组织病理学的重度放射中央神经系统肿瘤：病例报告
Handoko Handoko,Eka Susanto,Renindra Ananda Aman et al.
Handoko Handoko et al.
Diagnosing central nervous system (CNS) tumours post-radiation therapy is often complicated by treatment-induced histological changes. Molecular diagnostics, such as methylation profiling, offer robust tools to aid in accurate tumour classi...
Expression of Oct3/4 isoforms and its association with the risk of relapse in acute lymphoblastic leukemia [0.03%]
OCT3/4各异构体在急性淋巴细胞白血病复发风险中的表达及意义研究
Jorge Organista-Nava,Yazmín Gómez-Gómez,Corayma Yazmín Gómez-Sánchez et al.
Jorge Organista-Nava et al.
Oct3/4 is a transcription factor that maintains the stemness of both embryonic and adult stem cells. The Oct3/4 gene produces three isoforms: namely, Oct3/4A, Oct3/4B and Oct3/4B1. Increased Oct3/4 expression is associated with lower surviv...
Xi Chen,Jin-Zhou Yang,Ling-Yue Kong et al.
Xi Chen et al.
Epilepsy is a frequently occurring complication in patients with gliomas that substantially impairs their quality of life. The onset of epilepsy in patients with gliomas is driven by multiple mechanisms, including tumour-induced compression...
Efficacy of 12-month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real-world retrospective study [0.03%]
Romosozumab单药或与艾地罗联合治疗慢性肾病患者和非慢性肾病患者的骨质疏松疗效：一项真实世界回顾性研究
Teruya Uchiyama,Koichiro Murata,Toshibumi Kono et al.
Teruya Uchiyama et al.
Evidence regarding the clinical benefits of combination therapy with romosozumab and active vitamin D analogs in the treatment of osteoporosis is lacking. The aim of the present study was to evaluate the outcome of romosozumab (ROMO) as wel...
Syzygium samarangense fruit extract attenuates hyperglycemia in type 2 diabetic rats through modulation of oxidative stress and inflammation [0.03%]
Syzygium samarangense果实提取物通过调节氧化应激和炎症减轻2型糖尿病大鼠的高血糖症状
Kanchana Suksri,Nipaporn Muangchan,Bancha Yingngam et al.
Kanchana Suksri et al.
The global incidence of type 2 diabetes mellitus (T2DM), a chronic metabolic disorder, is on the rise, with persistent hyperglycemia contributing to vascular complications. The present study aimed to assess the preventive effects of Syzygiu...