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Exon 4 and intron 4 TP53 are both methylated in advanced-stage ovarian carcinomas

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Although intragenic CpG dinucleotides are conserved during evolution, they are also sensitive to methylation-dependent mechanisms. Methylation status of the TP53 introns 1, 3 and 4 have been analysed in stage III ovarian carcinoma (OC). In the present study, t... ...