Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects [0.03%]
牙龈卟啉单胞菌的 Gingipain 通过直接蛋白水解作用降解胰岛素受体导致胰岛素耐受性
Fen Liu,Bofeng Zhu,Ying An et al.
Fen Liu et al.
Periodontitis is a critical risk factor for the occurrence and development of diabetes. Porphyromonas gingivalis may participate in insulin resistance (IR) caused by periodontal inflammation, but the functional role and specific mechanisms ...
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models [0.03%]
一种新型口腔颌面外科手术机器人(KD-SR-01)在头颈外科手术中应用的评价：猪模型的前临床试验
Zhongkai Ma,Zhiyong Guo,Zhangfan Ding et al.
Zhongkai Ma et al.
Traditional open head and neck surgery often leaves permanent scars, significantly affecting appearance. The emergence of surgical robots has introduced a new era for minimally invasive surgery. However, the complex anatomy of the head and ...
Author Correction: FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression [0.03%]
作者更正：FUT8 介导的异常 N-糖基化 SEMA7A 促进头颈鳞状细胞癌的发展
Zhonglong Liu,Xiaoyan Meng,Yuxin Zhang et al.
Zhonglong Liu et al.
Published Erratum
International journal of oral science. 2024 Jul 2;16(1):49. DOI:10.1038/s41368-024-00307-x 2024
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation [0.03%]
仿生合成高密度脂蛋白(sHDL)纳米药物在根尖周骨炎治疗中的应用研究
Renan Dal-Fabbro,Minzhi Yu,Ling Mei et al.
Renan Dal-Fabbro et al.
Apical periodontitis (AP) is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth (i.e., dental pulp tissue), resulting in inflammation and apical bone resorption affecting 50% of the world...
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma [0.03%]
头颈鳞状细胞癌中通过STT3B介导的N-连接糖基化稳定EREG对于PDL1上调和免疫逃逸至关重要
Shengming Xu,Haifeng Wang,Yu Zhu et al.
Shengming Xu et al.
Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underlying EREG dysregulation remain largely unknown...
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis [0.03%]
来源于上皮细胞的外泌体miR-17-5p参与了异常的上皮-成纤维母细胞相互作用并诱导口腔粘膜纤维化的发展
Changqing Xie,Liang Zhong,Hui Feng et al.
Changqing Xie et al.
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to oral potentially malignant disorders. Abnormal fibroblast differentiation leading to disordered collagen metabolism i...
Expert consensus on endodontic therapy for patients with systemic conditions [0.03%]
伴有全身性疾病患者的根管治疗专家共识
Xin Xu,Xin Zheng,Fei Lin et al.
Xin Xu et al.
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. A systemic consideration of the patient's overall health along with oral conditions holds the utmost importance i...
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC [0.03%]
整合单细胞和批量转录组分析揭示了头颈鳞癌中丝氨酸-甘氨酸-一碳代谢的异质性及其不同的预后和治疗弱点
Lixuan Wang,Rongchun Yang,Yue Kong et al.
Lixuan Wang et al.
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment (TME), which significantly compromises the clinical outcomes and responses to therapy in head and neck ...
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma [0.03%]
三叉神经上的伤害性腺苷A2A受体通过调控CGRP释放来调节口腔鳞状细胞癌的进展
Lanxin Jiang,Ying Zhou,Shijie Tang et al.
Lanxin Jiang et al.
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of malignancy. However, it is yet t...
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis [0.03%]
多平台分析人类牙龈沟液揭示铁死亡在牙周炎临床进展中的相关调节性细胞死亡机制
Alfredo Torres,M Angélica Michea,Ákos Végvári et al.
Alfredo Torres et al.
Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases, yet its association with progressive periodontitis remains unexplored. To investigate the involvement and significance of ferroptosis in periodontitis ...