Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice [0.03%]
定义 hedgehog 途径拮抗剂诱导的小鼠额骨发育不全的关键时期
Yuanjing Jiang,Shixian Zhang,Chuanqing Mao et al.
Yuanjing Jiang et al.
The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To dete...
Chronic inflammation deteriorates structure and function of collagen fibril in rat temporomandibular joint disc [0.03%]
慢性炎症恶化大鼠颞下颌关节盘胶原纤维结构与功能
Sheng-Jie Cui,Yu Fu,Yan Liu et al.
Sheng-Jie Cui et al.
Collagen is the building component of temporomandibular joint (TMJ) discs and is often affected by inflammation in temporomandibular disorders. The macromechanical properties of collagen are deteriorated by chronic inflammation. However, th...
Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1 [0.03%]
咖啡酸苯乙酯通过血红素氧合酶1保护氧化应激并抑制炎症反应
Alexandra Stähli,Ceeneena Ubaidha Maheen,Franz Josef Strauss et al.
Alexandra Stähli et al.
Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester (CAPE), which is a potent inducer of heme oxygenase 1 (HO1), is a central active component of propolis, and the application of pr...
En Luo,Hanghang Liu,Qiucheng Zhao et al.
En Luo et al.
Rare diseases are usually genetic, chronic and incurable disorders with a relatively low incidence. Developments in the diagnosis and management of rare diseases have been relatively slow due to a lack of sufficient profit motivation and ma...
Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts [0.03%]
GDC-0449对体外同基因细胞模型（模拟成釉细胞囊肿）的影响
Jiemei Zhai,Heyu Zhang,Jianyun Zhang et al.
Jiemei Zhai et al.
Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destructio...
Mirali Pandya,Thomas G H Diekwisch
Mirali Pandya
Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals configured into decussating enamel rods. In recent years, multiple approaches have been introduced to generate or regenerate this highly attractiv...
Long-term dexamethasone treatment diminishes store-operated Ca2+ entry in salivary acinar cells [0.03%]
长效地塞米松治疗降低唾液腺泡细胞内钙离子释放操作性进入现象
Yuichiro Kusuda,Yusuke Kondo,Yuta Miyagi et al.
Yuichiro Kusuda et al.
Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gla...
Author Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp [0.03%]
作者更正：单一CD271标记从人牙髓中分离间充质干细胞
Ruth Alvarez,Hye-Lim Lee,Christine Hong et al.
Ruth Alvarez et al.
In the original version of this Article, Figure 1c was inadvertently assembled with a duplicate of Figure 1b. The correct image for Figure 1c, shown below, has been added in the HTML and PDF versions of the Article. This does not affect the...
Published Erratum
International journal of oral science. 2019 Jan 2;11(1):5. DOI:10.1038/s41368-018-0042-x 2019
Yun Feng,Qian Li,Jiao Chen et al.
Yun Feng et al.
Proteases are important molecules that are involved in many physiological and pathological processes of the human body, such as growth, apoptosis and metastasis cancer cells. They are potential targets in cancer diagnosis and biotherapy. In...
Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses [0.03%]
口腔鳞状细胞癌中口腔微生物组的致病性增强——来自元转录组分析的证据
Susan Yost,Philip Stashenko,Yoonhee Choi et al.
Susan Yost et al.
Oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community co...