Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice [0.03%]
牙龈炎相关口腔微生物群通过调节肠道和抑制色氨酸代谢加剧卵巢切除小鼠系统性破骨细胞生成
Nannan Wang,Jun Qian,Min Wang et al.
Nannan Wang et al.
Epidemiological studies have highlighted an association between periodontitis and osteoporosis. However, the mechanism underlining this association remains unclear. Here, we revealed significant differences in the salivary microbiota betwee...
Expert consensus on the diagnosis and management of tooth developmental anomalies [0.03%]
牙发育异常的诊断与处理专家共识
Jingxian Zhu,Mian Wan,Xiaohong Duan et al.
Jingxian Zhu et al.
Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process, resulting in abnormalities in tooth number, structure, and morphology. These anomalies typically manifest during c...
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux [0.03%]
靶向TARDBP-EGFR剪接轴的反义寡核苷酸通过ABCA1调节胆固醇流出抑制舌鳞状细胞癌进展
Nan Ni,Moxu Wang,Zhiran Yuan et al.
Nan Ni et al.
Splice quantitative trait loci (sQTL) serve as another critical link between genetic variations and human diseases, besides expression quantitative trait loci (eQTL). Their role in oral squamous cell carcinoma (OSCC) development remains une...
Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells [0.03%]
Wnt3a通过NKD1-MSX1轴介导的牙髓干细胞成odontogenic分化促进原位牙本质形成
Haoran Du,Qiong Li,Chenchen Zhou et al.
Haoran Du et al.
The functional regeneration of the dentin-pulp complex is pivotal for tooth preservation, yet the molecular mechanisms governing odontoblast differentiation remain poorly understood. In the current study, we revealed a distinct NKD1+ subpop...
MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD [0.03%]
MARCH2通过泛素化PTPRD抑制成牙本质细胞分化
Hao Feng,Jiaxin Niu,Zhi Chen et al.
Hao Feng et al.
Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein...
Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function [0.03%]
牙龈卟啉单胞菌通过影响中性粒细胞趋化和功能促进慢性阻塞性肺病发展
Luyao Zhang,Huan Tian,Yuanyuan Ma et al.
Luyao Zhang et al.
Chronic obstructive pulmonary disease (COPD), a disease responsible for early mortality worldwide, is well accepted to be associated with periodontitis epidemiologically. Although both of the diseases are the multi-microbial inflammatory di...
SMAD7 regulates the canonical Wnt signaling through TGF-β cascade crosstalk and SMAD7/β-CATENIN transcription factor complex formation during tooth regeneration [0.03%]
SMAD7通过TGF-β信号通路串扰和SMAD7/β-CATENIN转录因子复合物的形成调节 canonical Wnt 信号通路在牙齿再生中的作用
Qiuyu Chen,Zhi Liu,Bohuai Zhou et al.
Qiuyu Chen et al.
Tooth morphogenesis is orchestrated by a complex interplay of signaling pathways and transcription factors that control cell proliferation, apoptosis, and differentiation, with the Wnt/β-catenin signaling pathway playing a pivotal role. Ho...
Structure insight into FtsZ function maintaining under acid stress of Streptococcus mutans [0.03%]
酸胁迫下齿垢密螺旋体FtsZ蛋白结构及功能研究初探
Yuxing Chen,Yongliang Li,Jiahao Niu et al.
Yuxing Chen et al.
Understanding the acid resistance mechanism of S. mutans is crucial for preventing dental caries. FtsZ is the core protein for cell division in bacteria that can polymerize into Z-rings and drive cytokinesis. Our previous study revealed tha...
Next-generation craniomaxillofacial implants for reconstructive surgery: balancing biomechanics, biocompatibility, and bioactivity [0.03%]
下一代颅面植入物在重建手术中的应用：兼顾生物力学、生物相容性和生物活性
Bozhi Hou,Yuehua Li,Raymond Chung Wen Wong
Bozhi Hou
Next-generation craniomaxillofacial implants (CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics, biocompatibility, and bioactivity-the "3Bs". This review highlights recent progress in implant de...
Progressive tooth pattern changes in Cilk1-deficient mice depending on Hedgehog signaling [0.03%]
Hedgehog信号对Cilk1缺陷型小鼠进行性齿式变化的影响
Minjae Kyeong,Ju-Kyung Jeong,Dinuka Adasooriya et al.
Minjae Kyeong et al.
Primary cilia function as critical sensory organelles that mediate multiple signaling pathways, including the Hedgehog (Hh) pathway, which is essential for organ patterning and morphogenesis. Disruptions in Hh signaling have been implicated...