Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration [0.03%]
可溶性Notch激动剂促进人成釉细胞分化及类牙本质和类牙釉质组织的形成
Anjali P Patni,Rubul Mout,Ammar Alghadeer et al.
Anjali P Patni et al.
Enamel, the hardest mineralized material in the human body, protects the underlying living tissues, the dentin and pulp of the tooth. However, over 90% of adults have lost or damaged enamel and cannot regenerate the protective structure due...
Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder [0.03%]
单细胞转录图谱揭示了不同类型咬合障碍诱导的颞下颌关节骨关节炎中免疫细胞与软骨细胞之间的交叉对话机制
Kang Wang,Yusi Li,Shuaixi Xiang et al.
Kang Wang et al.
Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive degenerative disease in which the intricate mechanisms of the condyle cartilage damage are yet to be disclosed. A detailed characterization of cellular composition and signa...
ANKRD1 sustains a neurogenic BMSC niche and counters cognitive aging [0.03%]
ANKRD1维持神经发生BMSC生态位并对抗认知衰老
Zifei Wang,Xiaoyun Liu,Wenyu Zhen et al.
Zifei Wang et al.
Craniomaxillofacial bone marrow mesenchymal stromal cells (BMSCs) retaining neural crest-derived neurogenic niche is driven by lineage memory and niche homeostasis. Elucidating how the neurogenic potential is maintained is critical for neur...
Identification of GLDN+ odontogenic stem cells as crucial for human tooth development and regeneration [0.03%]
识别出GLDN+牙源性干细胞在人牙发育和再生中的重要作用
Chengcheng Liao,Jinglun Liu,Maojiao Li et al.
Chengcheng Liao et al.
The dental papilla (DP) is essential for the development of dentin and pulp. The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures during odontogenesis. How...
DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries [0.03%]
基于DNA和RNA的扩增子测序配对龈上菌斑与儿童严重早期儿童龋齿牙本质病损中的微生物群落差异
Allison A Naumann,Elissa M Elmorr,Eleanor I Lamont et al.
Allison A Naumann et al.
Early childhood caries is a form of tooth decay in children under the age of 6 and impacts more than 514 million children worldwide. Severe early childhood caries (S-ECC) represents the most advanced and aggressive form of early childhood c...
Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction [0.03%]
种植体通过Snx5-EGFR轴介导的机械转导唤醒peri-implant骨形成潜能
Xue Jiang,Yuteng Weng,Yanhuizhi Feng et al.
Xue Jiang et al.
Alveolar bone resorption during the socket healing process compromises subsequent restoration outcomes. Recent clinical evidence suggests that dental implant placement can effectively prevent such bone loss, yet the mechanisms remain elusiv...
Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways [0.03%]
慢性牙科照明通过血管和炎症途径破坏血视网膜屏障稳态
Haiyang Sun,Shuhuai Meng,He Cai et al.
Haiyang Sun et al.
Excessive lighting is integral to dentists' daily routines but can impair their vision, affecting personal and professional performance. Most studies focus on acute photodamage, neglecting chronic photo-injury from dental lighting and its i...
Stimuli-responsive, antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration [0.03%]
口腔生物膜控制和微生物群恢复的抗菌载药刺激响应纳米载体
Ding Chen,Dize Li,Linzhu Su et al.
Ding Chen et al.
Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials. Here, nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon ...
Engineered Lactobacillus reuteri for scavenging reactive oxygen species and modulating oral microflora in periodontitis therapy [0.03%]
用于牙周炎治疗的工程乳酸菌罗伊氏杆菌除清除活性氧和调节口腔微生物群研究
Yuqiang Wang,Ying Tang,Qianxiao Huang et al.
Yuqiang Wang et al.
The onset and progression of periodontitis are closely associated with subgingival dysbiosis and excessive localized oxidative stress. While some oral probiotics exhibit certain inhibitory effects on periodontitis-related pathogens, they of...
Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis [0.03%]
牙龈卟啉单胞菌源性细胞外囊泡通过促进Syk依赖的破骨细胞分化加重类风湿关节炎骨破坏
Jiajie Guo,Qiujing Qiu,Xiaoyuan Yan et al.
Jiajie Guo et al.
Rheumatoid arthritis (RA) is an autoimmune disorder that triggers progressive joint destruction by inducing excessive osteoclastogenesis. Porphyromonas gingivalis (Pg), the main pathogenic bacterium involved in periodontitis (PD), is closel...