A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning [0.03%]
Wnt10a-Notch信号轴控制Hertwig上皮根鞘细胞在根分叉模式中的行为
Kai Sun,Miao Yu,Jiayu Wang et al.
Kai Sun et al.
Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth, known as taurodontism; thus, indicating the critical role of Wnt10...
Promising dawn in tumor microenvironment therapy: engineering oral bacteria [0.03%]
肿瘤微环境治疗中令人鼓舞的进展：口腔细菌工程
Zifei Wang,Wansu Sun,Ruixue Hua et al.
Zifei Wang et al.
Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via microbes. Nowadays, the role of o...
Expert consensus on irrigation and intracanal medication in root canal therapy [0.03%]
根管治疗中冲洗及根管内给药的专家共识
Xiaoying Zou,Xin Zheng,Yuhong Liang et al.
Xiaoying Zou et al.
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved...
Dingming Huang,Xiaoyan Wang,Jingping Liang et al.
Dingming Huang et al.
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endo...
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma [0.03%]
单细胞转录组揭示细胞图谱并确定成釉细胞瘤中导致复发的增生肿瘤细胞
Gan Xiong,Nan Xie,Min Nie et al.
Gan Xiong et al.
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and a high recurrence rate. However, the mechanisms governing tumor initiation and recurrence are poorly understood. Here, we u...
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss [0.03%]
Tim4缺乏减少CD301b+巨噬细胞并加重牙周病骨质流失
Ziming Wang,Hao Zeng,Can Wang et al.
Ziming Wang et al.
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss. With the progression of periodontitis, the osteoimmunology microenvironment in periodontitis is dam...
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats [0.03%]
磨牙近中根尖远端的破骨细胞活性影响大鼠的牙齿正畸移动和牙根吸收
Wenhao Zheng,Xiaofeng Lu,Guangjin Chen et al.
Wenhao Zheng et al.
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection techniques is not sufficient, and t...
The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis [0.03%]
中性粒细胞-成骨细胞轴促进牙周病中的骨破坏
Yutaro Ando,Masayuki Tsukasaki,Nam Cong-Nhat Huynh et al.
Yutaro Ando et al.
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor act...
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis [0.03%]
口腔黏膜下纤维化中基质层的血小板源性蛋白1可抑制血管生成
Xiao Yang,Hui Zhao,Rui Li et al.
Xiao Yang et al.
A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that is largely induced by betel quid chewing. However, the lack of available models has challenged studies of angiogenesis...
Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts [0.03%]
基于数字病理学的人工智能模型对散发性牙源性角化囊肿进行鉴别诊断和预后判断
Xinjia Cai,Heyu Zhang,Yanjin Wang et al.
Xinjia Cai et al.
Odontogenic keratocyst (OKC) is a common jaw cyst with a high recurrence rate. OKC combined with basal cell carcinoma as well as skeletal and other developmental abnormalities is thought to be associated with Gorlin syndrome. Moreover, OKC ...