Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK [0.03%]
苯乙双胍通过NIBAN1和DDIT4在AMPK非依赖方式中激活内质网应激促进口腔鳞状细胞癌的自噬性细胞死亡
Dexuan Zhuang,Shuangshuang Wang,Huiting Deng et al.
Dexuan Zhuang et al.
The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor activities than metformin on diffe...
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images [0.03%]
基于锥形束CT图像的全自动AI口腔手术相关组织分割方法
Yu Liu,Rui Xie,Lifeng Wang et al.
Yu Liu et al.
Accurate segmentation of oral surgery-related tissues from cone beam computed tomography (CBCT) images can significantly accelerate treatment planning and improve surgical accuracy. In this paper, we propose a fully automated tissue segment...
Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration [0.03%]
解码支架诱导颅缝间充质组织再生的转录组和细胞机制
Jiayi Wu,Feifei Li,Peng Yu et al.
Jiayi Wu et al.
Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintaining undifferentiated mesenchyme...
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake [0.03%]
凋亡小体促进骨再生的机制研究
Yawen Cheng,Yuan Zhu,Yaoshan Liu et al.
Yawen Cheng et al.
Accumulating evidence has demonstrated that apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs; MSC-apoVs) are vital for bone regeneration, and possess superior capabilities compared to MSCs and other extracellular vesicle...
Chenchen Zhou,Peipei Duan,Hong He et al.
Chenchen Zhou et al.
Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts the dental-maxillofacial functions, facial esthetics, and long-term development of ~260 million children in China. Beyon...
Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing [0.03%]
一种用于感染伤口修复的四面体网格核酸/透明质酸-甲酸酐混合交联水凝胶及其抗菌抗炎性能
Cai Qi,Qiang Sun,Dexuan Xiao et al.
Cai Qi et al.
Bacterial resistance and excessive inflammation are common issues that hinder wound healing. Antimicrobial peptides (AMPs) offer a promising and versatile antibacterial option compared to traditional antibiotics, with additional anti-inflam...
Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification [0.03%]
单细胞分析揭示头颈鳞癌B细胞为主的免疫亚型并进行改善预后和治疗的分层
Kang Li,Caihua Zhang,Ruoxing Zhou et al.
Kang Li et al.
Head and neck squamous cell carcinoma (HNSCC) is characterized by high recurrence or distant metastases rate and the prognosis is challenging. There is mounting evidence that tumor-infiltrating B cells (TIL-Bs) have a crucial, synergistic r...
The evolution of robotics: research and application progress of dental implant robotic systems [0.03%]
口腔种植机器人系统研究及应用进展
Chen Liu,Yuchen Liu,Rui Xie et al.
Chen Liu et al.
The use of robots to augment human capabilities and assist in work has long been an aspiration. Robotics has been developing since the 1960s when the first industrial robot was introduced. As technology has advanced, robotic-assisted surger...
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression [0.03%]
FUT8介导的SEMA7A异常岩藻糖基化促进口腔鳞癌进展
Zhonglong Liu,Xiaoyan Meng,Yuxin Zhang et al.
Zhonglong Liu et al.
SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression. Aberrant glycosylation has been intricately linked with immune escape and tumor growth. SEMA7A is a highly glycosylated protein with five glyc...
Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice [0.03%]
牙周炎通过促进小鼠中IFNγ+t细胞浸润加剧肺动脉高压
Xiaoqian Meng,Linjuan Du,Shuo Xu et al.
Xiaoqian Meng et al.
Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease. In the current study, we showed that experimental periodontitis, which was established by ligation of molar...