Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC [0.03%]
整合单细胞和批量转录组分析揭示了头颈鳞癌中丝氨酸-甘氨酸-一碳代谢的异质性及其不同的预后和治疗弱点
Lixuan Wang,Rongchun Yang,Yue Kong et al.
Lixuan Wang et al.
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment (TME), which significantly compromises the clinical outcomes and responses to therapy in head and neck ...
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma [0.03%]
三叉神经上的伤害性腺苷A2A受体通过调控CGRP释放来调节口腔鳞状细胞癌的进展
Lanxin Jiang,Ying Zhou,Shijie Tang et al.
Lanxin Jiang et al.
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of malignancy. However, it is yet t...
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis [0.03%]
多平台分析人类牙龈沟液揭示铁死亡在牙周炎临床进展中的相关调节性细胞死亡机制
Alfredo Torres,M Angélica Michea,Ákos Végvári et al.
Alfredo Torres et al.
Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases, yet its association with progressive periodontitis remains unexplored. To investigate the involvement and significance of ferroptosis in periodontitis ...
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs [0.03%]
METTL7A介导的corinm6A甲基化逆转双磷酸盐对头面部BMSCs成骨分化的抑制作用
Yizhou Jin,Xiao Han,Yuejun Wang et al.
Yizhou Jin et al.
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells (BMSCs). Corin has recently been demonstrated to act as a key regulator in bone development a...
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure [0.03%]
多组学谱分析揭示了VDR是高脂肪饮食暴露后与骨质疏松症有关的间充质干细胞衰老的中心调节因子
Jiayao Chen,Shuhong Kuang,Jietao Cen et al.
Jiayao Chen et al.
The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. However, the specific mechanisms of HFD-induced osteoporosis are not fully understood. Our study shows that exposure to a...
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer's disease [0.03%]
人源牙髓间充质干细胞通过AKT-GSK3β-Nrf2信号通路改善阿尔茨海默病的神经病理和认知障碍反应
Wei Xiong,Ye Liu,Heng Zhou et al.
Wei Xiong et al.
Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer's disease (AD), particularly in the early stages of the disease. The multiplicity advantages of stem cell transplantation make it fascina...
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE-/- Mice on a high-fat diet [0.03%]
揭示口腔-肠道联系：慢性根尖周炎通过肠道菌群失调和改变的代谢物加速高脂饮食Apoe基因敲除小鼠动脉粥样硬化的发展
Guowu Gan,Shihan Lin,Yufang Luo et al.
Guowu Gan et al.
The aim of this study was to explore the impact of chronic apical periodontitis (CAP) on atherosclerosis in apoE-/- mice fed high-fat diet (HFD). This investigation focused on the gut microbiota, metabolites, and intestinal barrier function...
Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress [0.03%]
.Sinensetin通过与Bach1结合促进其泛素化降解来保护牙周病并改善氧化应激
Zhiyao Yuan,Junjie Li,Fuyu Xiao et al.
Zhiyao Yuan et al.
Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm. The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress. Sin...
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface [0.03%]
一种人类牙本质界面的三维体外模型显示牙本质表面具有远程成骨诱导性
William Macalester,Asme Boussahel,Rafael O Moreno-Tortolero et al.
William Macalester et al.
Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral defects. However, the oral cavity presents a ...
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling [0.03%]
抑制m1A可促进溶瘤病毒诱发的抗肿瘤免疫应答并下调MYC/PD-L1信号通路
Shujin Li,Tian Feng,Yuantong Liu et al.
Shujin Li et al.
N1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown. Us...