Pharmacological mechanisms and clinical applications between SGLT1 and SGLT2 inhibitors in type 2 diabetes and diabetic kidney disease: An analytic review [0.03%]
SGLT1和SGLT2抑制剂在2型糖尿病及糖尿病肾病中的药理机制和临床应用：分析性综述
Ziyang Zhang,Yupeng Li,Harvest F Gu et al.
Ziyang Zhang et al.
Sodium-glucose cotransporters 1 and 2 (SGLT1 and SGLT2), key members of the solute carrier (SLC) family, are pivotal for glucose reabsorption. Inhibitors targeting these transporters act by competitively occupying the glucose-binding site, ...
Dihydrotricetin from Euonymus hamiltonianus ameliorates neuroinflammation and exhibits neuroprotective effect in LPS-induced microglia [0.03%]
加拿大通草中二氢三查儿素改善神经炎症并具有保护神经的作用
Tianqi Huang,Jae Sik Yu,Gyo Chang Keum et al.
Tianqi Huang et al.
Microglia cells are the initial immune cells regulating neuroinflammation response. Under neuro-degenerative conditions, microglia exhibit as an over-activated phenotype, which generate large amounts of cytokines and inflammatory mediators....
Inhibition of GABA metabolism by β-lactam antibiotics affects encystation in Acanthamoeba [0.03%]
β-内酰胺类抗生素通过抑制GABA代谢影响阿卡纳巴菌的孢囊化作用
Chih-Ming Tsai,Yao-Tsung Chang,Yu-Jen Wang et al.
Chih-Ming Tsai et al.
Acanthamoeba keratitis (AK) is a painful corneal infection caused by pathogenic free-living amoebae of the genus Acanthamoeba, primarily affecting contact lens users with inadequate hygiene practices. Clinical manifestations include corneal...
Differential adipose tissue remodeling and metabolic effects of dolutegravir and bictegravir: implications for HIV therapy [0.03%]
多替拉韦和比克替拉韦的差异性脂肪组织重塑及代谢影响：对HIV治疗的意义
Laura Gisbert-Ferrándiz,Patricia García-Martínez,Juan V Esplugues et al.
Laura Gisbert-Ferrándiz et al.
Combined antiretroviral therapy (cART) has significantly improved the prognosis of people with HIV (PWH), but long-term metabolic side effects-particularly weight gain and adipose tissue dysfunction-remain an important concern. Among the co...
Therapeutic prospects of modulating TLR4/MAPK/ROS signalling in obesity-associated neuroinflammation [0.03%]
调节肥胖相关神经炎症的TLR4/MAPK/ROS信号通路的治疗前景
Drashti Sharma,Ram Narayanan Ravi,Amar Daud Iskandar Abdullah et al.
Drashti Sharma et al.
It is becoming more widely acknowledged that obesity is a chronic low-grade inflammatory disease that has a significant influence on brain health in addition to metabolic problems. Adipose tissue growth, macrophage polarization, and cytokin...
Tumor-derived extracellular vesicles: Bridging communication and next-generation theranostics [0.03%]
肿瘤来源的细胞外囊泡：沟通桥梁和下一代诊疗一体化技术
Jace Chen,Apple Verdiell,Carlos Formoso et al.
Jace Chen et al.
Cancer remains one of the leading causes of mortality worldwide, and despite advancements in therapeutic strategies-including chemotherapy, radiotherapy, immunotherapy, surgery, hormone therapy, and targeted therapy-a definitive cure remain...
CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice [0.03%]
CB1受体的激活和抑制在3xTg-AD小鼠中的不同调节作用及其对认知缺陷和神经病理学的影响
Minsook Ye,Jin Su Kim,Insop Shim
Minsook Ye
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition, tau hyperphosphorylation, neuroinflammation, oxidative stress, and progressive neuronal loss. The endocannabinoid system regulates synaptic function, inflammation, an...
An indole derivative of Ursolic acid, inhibits RANKL-induced osteoclast differentiation via modulating the Nrf2 and NFATc1/c-Fos axis: Targeting oxidative stress and osteoclastogenesis in managing rheumatoid arthritis [0.03%]
乌索酸吲哚衍生物通过调节Nrf2和NFATc1/c-Fos轴抑制RANKL诱导的破骨细胞分化：靶向氧化应激和破骨细胞生成以治疗类风湿性关节炎
Rupali Choudhary,Sweta,Jasha Momo H Anal et al.
Rupali Choudhary et al.
Rheumatoid arthritis (RA) encapsulates chronic autoimmune pathology, characterised by dysregulated immune responses that drive progressive joint destruction and systemic complications. Central to this process is aberrant osteoclast activati...
Triterpenoid saponins from Ilex latifolia inhibit breast cancer growth by disrupting the SREBP1/FASN-mediated lipid metabolic pathway [0.03%]
大叶冬青三萜皂苷通过扰乱SREBP1/FASN介导的脂质代谢通路抑制乳腺癌生长
Fangfang Wang,Mingjie Wang,Zihan Shi et al.
Fangfang Wang et al.
Dysregulated lipid metabolism is a hallmark of breast cancer progression, with the SREBP-1/FASN axis serving as a key driver of tumor growth and survival. Natural products offer a valuable reservoir of metabolic modulators, yet their mechan...
Alexandra Sviercovich,Etsuko Watanabe,Estefania S Fernandez et al.
Alexandra Sviercovich et al.
Oxytocin (OT) is a neurohypophyseal peptide with decreased expression during aging, essential for skeletal muscle homeostasis, and counteracts sarcopenia in aged mice. Yet, its function in cancer cachexia remains unexplored. We investigated...