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CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice

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Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition, tau hyperphosphorylation, neuroinflammation, oxidative stress, and progressive neuronal loss. The endocannabinoid system regulates synaptic function, inflammation, and redox homeostasis... ...