Comparative study of the therapeutic effects of sturgeon collagen peptide chelate-zinc on osteoarthritis induced by anterior cruciate ligament transection and medial meniscectomy in obese male rats [0.03%]
骨关节炎外科手术建模肥胖大鼠软骨糖胺聚糖流失的锌指蛋白及鲟鱼胶原肽螯合锌补充对其疗效的比较研究
Jerrell Felim,Pei-Yu Wang,Min-Hsiung Pan et al.
Jerrell Felim et al.
Osteoarthritis (OA), marked by articular cartilage degeneration, is significantly influenced by obesity, a major risk factor that promotes inflammation and oxidative stress. Sturgeon peptide (SP) is recognized for promoting collagen synthes...
Metabolite phenotyping of kobusin and identification of glutathione conjugates with kobusin catechol metabolite [0.03%]
毛越子甘碱代谢产物的表型分析及其与谷胱甘肽结合物的鉴定
Min Seo Lee,Ju-Hyun Kim,Yong-Yeon Cho et al.
Min Seo Lee et al.
We aimed to investigate the metabolic pathways of kobusin, a tetrahydrofurofuran lignan with benzo[1,3]dioxole group, which exhibits antioxidant, anti-inflammatory, and anticancer activities. The metabolic profiles of kobusin, following inc...
Advances in drug-loaded microspheres for targeted, controlled, and sustained drug delivery: Potential, applications, and future directions [0.03%]
载药微球在靶向、控释和缓释药物递送方面的研究进展：潜力、应用及未来方向
Ye Jin Lee,Moon Suk Kim
Ye Jin Lee
Drug-loaded microspheres are an innovative technology in drug delivery systems (DDS), addressing many limitations of conventional methods. Their ability to enable controlled release, precise targeting, and broad drug compatibility makes the...
Sex-dependent alteration of the enteric neuromuscular function after antibiotic-induced dysbiosis in juvenile mice and effect of Lactocaseibacillus rhamnosus GG [0.03%]
抗生素诱导的菌群失调对小鼠肠神经系统和肌肉功能的影响及鼠李糖乳杆菌GG的作用性别依赖性改变及瑞士圆线虫
Annalisa Bosi,Davide Banfi,Jaïr Dilmé Capó et al.
Annalisa Bosi et al.
Perturbations of the gastrointestinal (GI) microbiota (i.e. dysbiosis) in early life may induce vulnerability of the enteric nervous system (ENS), contributing to early onset GI disorders, such as irritable bowel syndrome (IBS). Probiotics,...
Lysine demethylase 6 (KDM6): A promising therapeutic target in autoimmune disorders and cancer [0.03%]
组蛋白赖氨酸去甲基化酶6(KDM6)在自身免疫性疾病和癌症治疗中的潜在作用与机制研究进展
Mahsa Nastaranpour,Aman Damara,Stephan Grabbe et al.
Mahsa Nastaranpour et al.
Epigenetic dynamics, which influence gene expressions independent of DNA sequence alterations, play a pivotal role in regulating chromatin structure and transcription. Among these modifications, the dynamic methylation and demethylation of ...
Host-defence caerin 1.1 and 1.9 peptides suppress B16 melanoma growth by inducing apoptosis and disrupting lipid metabolism [0.03%]
宿主防御肽caerin 1.1和1.9通过诱导凋亡和扰乱脂质代谢来抑制B16黑素瘤生长
Jiawei Fu,Xinyi Song,Rongmi Mo et al.
Jiawei Fu et al.
Caerin peptides, originally isolated from the skin secretions of Australian tree frogs of the genus Litoria, have shown potential as anti-cancer agents in previous studies. This study investigates the impact of caerin 1.1 and 1.9 (F1/F3) pe...
VU0810464, a selective GIRK channel activator, improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomers [0.03%]
VU0810464，一种选择性的GIRK通道激活剂，可改善淀粉样蛋白-寡聚体破坏的海马区依赖性突触可塑性和记忆功能
Jaime Mulero-Franco,Raquel Jimenez-Herrera,Ana Contreras et al.
Jaime Mulero-Franco et al.
Selective pharmacological activation of G protein-gated inwardly rectifying K⁺ (GIRK) channels -a key physiological determinant of neuronal excitability control- has proven highly effective in counteracting amyloid-β oligomer (oAβ)-induc...
Fermented Morinda citrifolia extract improves late-onset hypogonadism in aged rats [0.03%]
发酵Morinda citrifolia提取物可改善衰老大鼠迟发性性腺功能减退症状
Hee-Yeon Kwon,Hyesung Lee,Ji-Soo Choi et al.
Hee-Yeon Kwon et al.
Background: Late-onset hypogonadism (LOH) is an age-associated condition characterized by a progressive decline in testosterone levels. It manifests as reduced libido, infertility, muscle loss, and cognitive impairment in...
The immune checkpoint LILRB4 promotes immune evasion and is correlated with disease progression and secondary malignancies in chronic lymphocytic leukemia [0.03%]
免疫检查点LILRB4促进免疫逃逸并与慢性淋巴细胞白血病的疾病进展和继发性恶性肿瘤相关
Christian Sordo-Bahamonde,Alejandra Martínez-Pérez,Rocío Granda-Díaz et al.
Christian Sordo-Bahamonde et al.
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal malignant B cells and heterogeneous clinical outcomes. This study explored the role of the immune checkpoint receptor LILRB4 (ILT3), previously implicated in ...
Corrigendum to "Can ketamine therapy overcome treatment-resistant depression in Alzheimer's disease and older adults? Preclinical and clinical evidence" [Biomed. Pharmacother. 188 (2025) 118199] [0.03%]
关于“氯胺酮治疗能否克服阿尔茨海默病和老年人难治性抑郁症？前临床和临床证据”一文的勘误[生物医学与药物治疗学第188卷（2025年）118199号论文]
Mario Altamura,Ivana Leccisotti,Maria Claudia Moretti et al.
Mario Altamura et al.