Effect of electron beam irradiation of piroxicam on inhibiting the inflammatory response in LPS-stimulated BMDCs and sepsis-induced mouse models [0.03%]
电子束照射对吡罗昔康抗LPS刺激BMDCs炎症反应及脓毒症小鼠模型的作用效果研究
Bo-Gyeong Yoo,Gyeong Han Jeong,Ha-Yeon Song et al.
Bo-Gyeong Yoo et al.
Non-steroidal anti-inflammatory drugs (NSAIDs), such as piroxicam (PX), are widely used but are limited by gastrointestinal and hepatic toxicity. Electron beam (e-beam) irradiation can induce structural diversification of small molecules, p...
Unleashing the prospects of nanomaterials in the treatment of autoimmune and inflammatory diseases [0.03%]
纳米材料在自身免疫和炎症疾病治疗中的前景展望
Vijayakumar G Gayathri,P Abdul Rasheed,Jagadeesh Bayry
Vijayakumar G Gayathri
Autoimmune diseases arise when the immune system, responsible for safeguarding the body against infections and other foreign agents mistakenly attacks healthy cells and tissues. This leads to acute and chronic inflammation, tissue damage, a...
Extracellular vesicle depletion improves transient gene expression performance and alters cellular transcriptional responses in CHO cell [0.03%]
去除细胞培养上清中胞外囊泡可提高CHO细胞瞬时表达效率并改变其转录组反应
Marzia Rahimi,Pol Pérez-Rubio,Juliana Vargas-Gracia et al.
Marzia Rahimi et al.
Chinese hamster ovary (CHO) cells are widely used for the production of recombinant biologics, but their application in transient gene expression (TGE) systems remains limited by reduced efficiency at high cell density, known as the cell de...
From diabetic foot to dementia: A neurovascular continuum linking systemic diabetic vasculopathy, cerebral small vessel disease, and glymphatic dysfunction [0.03%]
从糖尿病足到痴呆：系统性糖尿病血管病、脑小血管病和胶淋巴运输障碍的神经血管连续带理论
Yuriko Inoue,Tatsunori Oguchi,Akio Inoue et al.
Yuriko Inoue et al.
Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), is increasingly recognized as a major risk factor for cognitive decline and dementia. Epidemiological studies consistently demonstrate that individuals with diabetes exhibit a...
Acid sphingomyelinase is an age-dependent host cell factor for adenovirus entry and a pharmacological target for synergistic combination therapy with brincidofovir [0.03%]
酸性鞘氨醇磷酸脂酶是衰老依赖的腺病毒侵染宿主细胞因子及溴西多福韦协同治疗作用靶点
Sophie Post,Mohamed Zamzamy,Luca Benthien et al.
Sophie Post et al.
Endolysosomal compartments act as critical sorting hubs for viral entry, trafficking, and uncoating, yet the contribution of lipid-modifying enzymes to these processes remains incompletely understood. Acid sphingomyelinase (ASM), a key regu...
Refining free fatty acid receptor agonism for metabolic control: Pharmacological and functional features of novel dual GPR40/GPR120 ligands [0.03%]
用于代谢调控的游离脂肪酸受体激动剂的优化：新型GPR40/GPR120双效配体的药理学及功能特征
Kashi Brunetti,Bruno Fassari,Elisabetta Catalani et al.
Kashi Brunetti et al.
Metabolic disorders require therapeutic strategies targeting complementary pathways beyond current incretin-based therapies. Free fatty acid receptors GPR40 (FFAR1) and GPR120 (FFAR4) regulate insulin and incretin secretion as well as lipid...
Corrigendum to 'A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis)' [Biomed. Pharmacother. 181 (2024) 117706] [0.03%]
关于“靶向肺动脉高压的新视角：程序性细胞死亡途径（自噬、细胞焦亡、铁死亡）”的勘误[Biomed. Pharmacother. 181 (2024) 117706]
Qingliang Ge,Tianqing Zhang,Jiangbiao Yu et al.
Qingliang Ge et al.
Comparative in vitro evaluation of fourth-generation anti-GPC3 CAR T-cells in hepatocellular carcinoma [0.03%]
第四代抗GPC3的CAR-T细胞对肝癌的体外评估研究
Thaweesak Chieochansin,Kornkan Choomee,Napat Angkathunyakul et al.
Thaweesak Chieochansin et al.
hepatocellular carcinoma (HCC) is the most common primary liver cancer and remains difficult to treat in advanced stages because of tumor heterogeneity and an immunosuppressive microenvironment. Chimeric antigen receptor (CAR) T-cell therap...
Inhibition of the ZEB1-BCL2 axis in cancer-associated fibroblasts as a strategy to improve chemotherapy response in intrahepatic cholangiocarcinoma [0.03%]
针对肝内胆管癌改善化疗效果的抑制癌症相关成纤维细胞ZEB1-BCL2轴的新策略研究
Ester Gonzalez-Sanchez,Marie Vallette,Lucia Garcia-Collado et al.
Ester Gonzalez-Sanchez et al.
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive tumour from the biliary tree that is characterized by a prominent desmoplastic stroma, mainly composed of cancer-associated fibroblasts (CAF), and a poor prognosis due to its late clin...
From DNA-encoded library (DEL) screening to in vivo validation: LILRB4 (ILT3)-targeted small molecules reprograms myeloid immune suppression [0.03%]
从DNA编码库筛选到体内验证：靶向LILRB4（ILT3）的小分子重塑髓系免疫抑制
Somaya A Abdel-Rahman,Moustafa T Gabr
Somaya A Abdel-Rahman
Alzheimer's disease (AD) remains a major unmet clinical challenge, with limited therapeutic strategies capable of effectively modulating neuroimmune dysfunction. Leukocyte immunoglobulin-like receptor B4 (LILRB4/ILT3) has recently emerged a...