Peptide-assisted lipofection enables efficient non-viral delivery of large CRISPR/Cas9 constructs for genome editing applications [0.03%]
肽辅助脂质转染可有效实现大份量CRISPR/Cas9元件的非病毒递送以应用于基因组编辑
Yeong Chae Ryu,Gang Bao,Byeong Hee Hwang
Yeong Chae Ryu
Efficient and safe delivery of large genetic constructs such as CRISPR/Cas9 plasmids remains a critical bottleneck in gene therapy. In this work, the peptide-assisted lipofection (PAL) system was developed as a breakthrough non-viral vector...
Niosomal co-delivery of metformin and telaglenastat: A targeted nanotherapeutic strategy for breast cancer treatment and metastasis suppression in 2D and 3D models [0.03%]
二甲双胍和Telaglenastat尼奥溶酶共输送：2D和3D模型中治疗乳腺癌及转移抑制的靶向纳米治疗策略
Ahlam Zaid Alkilani,Haneen A Basheer,Maram A Alhusban et al.
Ahlam Zaid Alkilani et al.
Overexpression of glucose transporter-1 (GLUT-1) and glutaminase-1 (GLS-1) underlies the metabolic dependence of breast cancer cells on glucose and glutamine. Exploiting this vulnerability, a dual-drug niosomal delivery system was developed...
Effects of GnRH agonists and antagonists on cardiovascular and metabolic systems in adults: Mechanistic pathways and risk management [0.03%]
促性腺激素释放素激动剂和拮抗剂对成人心血管和代谢系统的影响：作用机制和风险管理
Atoosa Etezadi,Seyed Mehdi Marashi,Leila Nazari et al.
Atoosa Etezadi et al.
Gonadotropin-releasing hormone (GnRH) therapy, widely used in the management of reproductive and oncological disorders in adult humans, has been increasingly linked to metabolic and cardiovascular complications. This review focuses on the h...
Indoxyl sulfate promoted glutamine metabolism and cell proliferation in urothelial carcinoma involving Runx2 [0.03%]
吲哚硫酸盐通过Runx2促进膀胱尿路上皮癌细胞的谷氨酰胺代谢和增殖
Jian-Ri Li,Tung-Min Yu,Yen-Chuan Ou et al.
Jian-Ri Li et al.
Patients with Chronic Kidney Disease (CKD) have an increased risk and poor prognosis of becoming diagnosed with urothelial carcinoma. Currently, the linking mechanisms underlying the connection between CKD and urothelial carcinoma are not w...
Carla Rojo,Aaron Otero,Maria Elizalde et al.
Carla Rojo et al.
Cancer treatment remains challenging due to heterogeneous responses to immunotherapy across patients and tumor types. Innovative strategies are required to overcome immune evasion. We have identified the splicing factor SLU7 as essential fo...
As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition [0.03%]
一种新型的第一类双功能TREM2调节剂As48：受体激活和脱落抑制
Sungwoo Cho,Farida El Gaamouch,Saurabh Upadhyay et al.
Sungwoo Cho et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) dysfunction contributes to Alzheimer's disease pathogenesis, yet current therapeutics cannot prevent ADAM-mediated receptor shedding that diminishes signaling efficacy. Using Affinity...
Androgen receptor blockade and its effect on PSMA-localization in prostate cancer: Implications for radioligand therapy [0.03%]
雄激素受体阻断及其对前列腺癌中PSMA定位的影响：放射配体治疗的启示
Flavien Devaux,Kareem Beltagi,Thomas Frank Ermler et al.
Flavien Devaux et al.
Prostate-specific membrane antigen (PSMA) is a key target for radioligand therapy (RLT) in prostate cancer (PCa). However, its subcellular localization is critical, as ligand uptake via PSMA mediated endocytosis influences therapeutic effic...
Synergistic antiproliferative and pro-apoptotic activity of dacarbazine combined with 2-aminoethyl dihydrogen phosphate in melanoma cells [0.03%]
哒卡巴嗪联合乙二胺二氢磷酸盐在黑色素瘤细胞中的协同抗增殖和促凋亡作用
Thalles Anthony Duarte de Oliveira,Gustavo Henrique Doná Rodrigues Almeida,Ranya Sthephanie Nascimento Ribeiro et al.
Thalles Anthony Duarte de Oliveira et al.
Cutaneous melanoma is an aggressive malignancy characterized by high metastatic potential and resistance to conventional chemotherapeutic regimens. Dacarbazine, an alkylating agent historically used as a first-line drug, exhibits limited cl...
Enhanced neurotoxic effects following co-administration of methamphetamine and ethanol in rats: Insights from integrated analysis of behavior, pharmacokinetics, and metabolomics [0.03%]
甲胺磷和乙醇联合给药后大鼠神经毒性增强：行为、药代动力学和代谢组学的综合分析提效
Mingyu Kim,Sang-Hoon Song,Suji Kim et al.
Mingyu Kim et al.
Methamphetamine (MA) is a psychostimulant with high potential for abuse and neurotoxicity, and overdose or concurrent use with ethanol (EtOH) has been associated with increased hospitalizations and mortality. This study investigated the pha...
Harnessing cuproptosis for pancreatic cancer therapy: From molecular insights to clinical prospects [0.03%]
铜死亡在胰腺癌治疗中的作用：从分子机制到临床前景
Ali Darzi,Siavash Boroumandi,Pouriya Khajegi et al.
Ali Darzi et al.
Pancreatic cancer (PC) remains a high-fatality malignancy with limited clinical progress, characterized by aggressive biology, marked resistance to standard therapies, and dismal outcomes. Even with state-of-the-art resection, radiotherapy,...