As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition
{{output}}
Triggering receptor expressed on myeloid cells 2 (TREM2) dysfunction contributes to Alzheimer's disease pathogenesis, yet current therapeutics cannot prevent ADAM-mediated receptor shedding that diminishes signaling efficacy. Using Affinity Selection-Mass Spe... ...
