Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases: A proof-of-concept study [0.03%]
曲马替尼介导的MEK抑制作用损害了胶质母细胞瘤伴颅外转移患者衍生肿瘤模型中癌细胞的存活和侵袭：一项概念验证研究
Metka Novak,Bernarda Majc,Marija Skoblar Vidmar et al.
Metka Novak et al.
Glioblastoma (GBM) remains one of the most lethal human malignancies, yet extraneural metastases are exceptionally rare and poorly understood. Standard treatment-surgical resection followed by chemoradiotherapy-offers only modest survival b...
Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5 [0.03%]
靶向SARS-CoV-2 nsp3和nsp5的高效抗病毒药物候选物
Mathilde Galais,Guillaume Herlem,Sandy Haidar Ahmad et al.
Mathilde Galais et al.
Faced with the repeated emergence of three major epidemics caused by coronaviruses over the past 20 years (SARS-CoV in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019), the development of novel antiviral treatments has become a critical publ...
The estrogen-integrin αvβ3 crosstalk in breast cancer: Modulating PD-L1 and immune evasion [0.03%]
乳腺癌中雌激素与整合素αvβ3的相互作用：调节PD-L1和免疫逃逸
Dana R Crawford,Yung-Ning Yang,Feng-Cheng Liu et al.
Dana R Crawford et al.
The mechanisms governing PD-L1 expression in breast cancer are highly complex and context-dependent. This article proposes a novel "dual-track" regulatory model to resolve the conflicting roles of estrogen in tumor immunity. Genomic signali...
Intravenous immunoglobulin recalibrates monocyte responses to abortive SARS-CoV-2 infection across viral variants [0.03%]
静脉用免疫球蛋白可校正败血症型新冠病毒感染的单核细胞反应（涵盖各种病毒谱系）
Meryem Alaka,Benoit Desnues
Meryem Alaka
Monocytes contribute to inflammation during coronavirus disease 2019 (COVID-19), yet their capacity to support productive infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the impact of viral evolution on their ...
Corrigendum "Intra-abdominal transplantation of PLGA/PCL/M13 phage electrospun scaffold induces self-assembly of lymphoid tissue-like structure" [Biomed. Pharmacother. 173 (2024) 116382] [0.03%]
“PLGA/PCL/M13噬菌体电纺支架的腹腔内移植诱导类似淋巴组织结构自组装”的勘误[Biomed. Pharmacother. 173 (2024) 116382]
Zohreh Safari,Majid Sadeghizadeh,Ahmad Zavaran Hosseini et al.
Zohreh Safari et al.
PARP inhibition induces a redox-dependent dormant reservoir vulnerable to disulfiram in high-grade serous ovarian cancer [0.03%]
PARP抑制通过一种依赖于红氧化状态的休眠库诱导剂硫胺敏感的高等级浆液性卵巢癌模型中的活性形式
Sutthipun Suriya,Supawan Jamnongsong,Chanettee Jamyuang et al.
Sutthipun Suriya et al.
Resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) in high-grade serous ovarian cancer (HGSOC) is increasingly driven by non-genetic drug-tolerant dormant cell populations, yet the adaptive programs sustaining these cells remain p...
Preserved motor function and prolonged sensory local anesthesia with novel PLGA microparticles co-encapsulating lidocaine and capsaicin [0.03%]
新型PLGA微球联合封装利多卡因和辣椒素以保留运动功能并延长感觉局部麻醉作用
Asami Ishii,Yuta Aida,Toshiyuki Ikoma et al.
Asami Ishii et al.
Lidocaine (LID) provides rapid local anesthesia but lacks nerve-type selectivity, causing undesired motor impairment, and typically suffers from a rapid washout effect. To address these acute-phase limitations, we developed biodegradable po...
Paclitaxel-loaded nanostructured lipid carriers surface-functionalized with N6L for pancreatic cancer [0.03%]
负载N6L的紫杉醇纳米结构脂质载体用于胰腺癌治疗
Laura Larue,Blandine Brissault,Cléa Chesneau et al.
Laura Larue et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies, with limited therapeutic options. Despite advances in chemotherapy, such as FOLFIRINOX and Abraxane® (nab-paclitaxel) combined with gemcita...
O-GlcNAc transferase as an oncogenic regulator in hematologic malignancies: Mechanisms, disease contexts, and therapeutic perspectives [0.03%]
O-连接-N-乙酰葡萄糖胺转移酶在血液系统恶性肿瘤中的致癌调节作用：机制、疾病背景及治疗前景
Marissa El Hajje,Juan Luiz Coelho-Silva,João Agostinho Machado-Neto et al.
Marissa El Hajje et al.
O-GlcNAc transferase (OGT) catalyzes the addition of N-acetylglucosamine to serine and threonine residues of nuclear and cytoplasmic proteins, coupling cellular metabolic state to the post-translational regulation of hundreds of substrates....
Three-dimensional cell cultures as an in vitro tool for ovarian cancer modeling and natural product discovery [0.03%]
三维细胞培养作为卵巢癌建模和天然药物发现的体外工具
Mirian Carolini Esgoti Aal,Matheus Naia Fioretto,Tainá Dorte da Silva et al.
Mirian Carolini Esgoti Aal et al.
Ovarian cancer (OC) remains the most common cancer among women, with high incidence and mortality rates, prompting extensive investigation across in vivo, in vitro, and clinical settings. In this context, in vitro cell culture models have b...