O-GlcNAc transferase as an oncogenic regulator in hematologic malignancies: Mechanisms, disease contexts, and therapeutic perspectives
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O-GlcNAc transferase (OGT) catalyzes the addition of N-acetylglucosamine to serine and threonine residues of nuclear and cytoplasmic proteins, coupling cellular metabolic state to the post-translational regulation of hundreds of substrates. Hematologic maligna... ...