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Preserved motor function and prolonged sensory local anesthesia with novel PLGA microparticles co-encapsulating lidocaine and capsaicin

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Lidocaine (LID) provides rapid local anesthesia but lacks nerve-type selectivity, causing undesired motor impairment, and typically suffers from a rapid washout effect. To address these acute-phase limitations, we developed biodegradable poly (lactic-co-glycol... ...