Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders [0.03%]
解码Nectin相互作用组：对大脑发育、可塑性和神经系统疾病的影响
Shreyash Santosh Yadav,Krishnamoorthy Srinivasan,Shyam Sunder Sharma et al.
Shreyash Santosh Yadav et al.
The nectin family of cell adhesion molecules (CAMs) comprising nectins and nectin-like molecules has emerged as a key regulator of various pivotal neural processes, including neuronal development, migration, synapse formation, and plasticit...
Modulation of α-Synuclein Fibrillation and Toxicity by 4-Phenylbutyric Acid [0.03%]
4-苯丁酸对α-突触核蛋白纤维化及毒性的影响
Kristos Baffour,Neelima Koti,Tony Nyabayo et al.
Kristos Baffour et al.
The protein misfolding and aggregation of α-synuclein (α-Syn) into neurotoxic amyloids underlies the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). Emerging evidence suggests that 4-phenylbutyrate (PBA) may p...
Procognitive Potential of Neuroprotective Triazine 5-HT6 Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile [0.03%]
神经保护三嗪5-HT6受体拮抗剂对大鼠慢性在 vivo 活动的促认知潜能测试：计算机辅助了解元素在药理特性中的作用差异
注：这里的"procognitive potential"翻译为“促认知潜能”可能不是最常用的表达，也可能视上下文被译作“促进认知的潜力”。另外，“Chalcogen-Differences”的翻译基于化学领域的术语，直译为“元素（指氧、硫、硒和碲等）差异”，不过这一部分的具体中文表述可以根据更详细的上下文进行调整。
Magdalena Jastrzębska-Więsek,Sabrina Garbo,Agnieszka Cios et al.
Magdalena Jastrzębska-Więsek et al.
Among serotonin receptors, the 5-HT6 subtype is an important protein target and its ligands may play a key role in the innovative treatment of cognitive disorders. This study aimed to extend the body of preclinical research on two naphthyl-...
Differential Effects of Aβ Peptides on the Plasmin-Dependent Degradation of ApoE3 and ApoE4 [0.03%]
Aβ肽对载脂蛋白E3和E4的纤溶酶依赖性降解的差异影响
Merc M Kemeh,Anthony J Furnelli,Noel D Lazo
Merc M Kemeh
The ApoE4 allele of apolipoprotein E (ApoE4) is the strongest hereditary predisposition to Alzheimer's disease, even though ApoE4 only differs from the more common ApoE3 by a single amino acid substitution. Previous studies have shown that ...
Inhibition of the Parkinson's Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family [0.03%]
1,2,3,4-四氢异喹啉家族内源性神经毒素对帕金森氏病相关蛋白DJ-1的抑制作用
Catherine Laurent,Gabrielle Poncet,Tristan Herskovits et al.
Catherine Laurent et al.
The protein DJ-1 appears to play a protective role in the development of Parkinson's disease (PD). Here, we show that endogenous neurotoxins of the 1,2,3,4-tetrahydroisoquinoline family (TIQs), formed upon reaction of various aldehydes such...
Enhanced Pain Sensitization Induced by Chronic Sleep Deprivation: The Role of Dopamine D2 Receptors-Dependent Homer1a Protein [0.03%]
慢性睡眠剥夺引起增强的疼痛敏化：多巴胺D2受体依赖的Homer1a蛋白的作用
Chao Fu,Peng Wu,Fancan Wu et al.
Chao Fu et al.
Numerous studies have demonstrated a positive correlation between sleep disorders and hyperalgesia. These sleep disorders adversely affect the descending pain regulatory system. Researchers have extensively studied the midbrain dopamine sys...
Integrating Rapid Evaporative Ionization Mass Spectrometry Classification with Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry to Unveil Glioblastoma Overall Survival Prediction [0.03%]
集成快速蒸发离子化质谱分类，矩阵辅助激光解吸电离质谱成像和液相色谱-串联质谱以揭示胶质母细胞瘤总生存预测能力
Tim F E Hendriks,Angeliki Birmpili,Steven de Vleeschouwer et al.
Tim F E Hendriks et al.
Glioblastoma multiforme (GBM) is a highly aggressive brain cancer with a median survival of 15 months. Despite advancements in conventional treatment approaches such as surgery and chemotherapy, the prognosis remains poor. This study invest...
Discovery of New Pentapeptide Inhibitors Against Amyloid-β Aggregation Using Word2Vec and Molecular Simulation [0.03%]
使用Word2Vec和分子模拟发现新的五肽抑制剂来对抗淀粉样蛋白-β聚集
Yin-Lei Han,Huan-Huan Yin,Chen Li et al.
Yin-Lei Han et al.
Alzheimer's disease (AD) is characterized by the aggregation of amyloid-β (Aβ) peptides into toxic oligomers and fibrils. The efficacy of existing peptide inhibitors based on the central hydrophobic core (CHC) sequence of Aβ42 remains li...
Oroxylin A Attenuates Homocysteine-Induced Blood-Brain Barrier (BBB) Dysfunction by Reducing Endothelial Permeability and Activating the CREB/Claudin-5 Signaling Pathway [0.03%]
Oroxylin A通过减少内皮通透性和激活CREB/ Claudin-5信号通路来减轻同型半胱氨酸诱导的血脑屏障功能障碍
Yilu Bao,Baiyang Sheng,Ping Lv
Yilu Bao
Recent reports have indicated that elevated levels of homocysteine (Hcy) are closely linked to blood-brain barrier (BBB) dysfunction in neurological disorders. Oroxylin A (OA) is a key bioactive flavonoid that has been reported to regulate ...
SeroWare: An Open-Source Software Suite for Voltammetry Data Acquisition and Analysis [0.03%]
SeroWare：用于伏安法数据采集和分析的开源软件套件
Cameron S Movassaghi,Rahul Iyer,Maya E Curry et al.
Cameron S Movassaghi et al.
Voltammetry is widely used for fast, data-dense measurements of redox-active analytes in versatile environments, including the brain. Voltammetry requires minimal hardware beyond a potentiostat, a front-end amplifier, and a computer. Noneth...