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Modulation of α-Synuclein Fibrillation and Toxicity by 4-Phenylbutyric Acid

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The protein misfolding and aggregation of α-synuclein (α-Syn) into neurotoxic amyloids underlies the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). Emerging evidence suggests that 4-phenylbutyrate (PBA) may play a role as a pot... ...