Hippocampal Commissural Circuitry Shows Asymmetric cAMP-Dependent Synaptic Plasticity [0.03%]
海马 commissural 回路表现出不对称的 cAMP 依赖性突触可塑性
Lukas Faiss,Aikaterini Salivara,Silvia Oldani et al.
Lukas Faiss et al.
Hemispheric asymmetries in NMDAR-dependent synaptic plasticity have been described in hippocampal area CA1, but it remains unclear whether similar lateralized mechanisms exist for cyclic adenosine monophosphate (cAMP)-dependent plasticity. ...
Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics [0.03%]
扎硫酸靛酚是一种非解离型、非幻觉型神经成形素，其治疗效果可与氯胺酮和 psychedelics 媲美
Rajiv Agrawal,Daniel Gillie,Alison Mungenast et al.
Rajiv Agrawal et al.
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid and enduring therapeutic effects of psyche...
Takashi Ohgita,Norihiro Namba,Nao Minami et al.
Takashi Ohgita et al.
Deposition of fibrillar aggregates of α-synuclein (αS) in the brain is a hallmark of αS-associated neurodegenerative diseases. Heparin, a structural analog of cell-surface heparan sulfate, modulates the kinetics of αS fibrillation and t...
Understanding Structural Destabilization and Amyloid Aggregation in ALS-Related Neurodegenerative Disorder: An In Silico and Experimental Analysis of SOD1 Variants [0.03%]
利用计算机模拟和实验分析ALS相关神经退行性疾病中的结构不稳定和淀粉样蛋白聚集：SOD1突变体的分析研究
Nazanin Soleimanifard,Bagher Seyedalipour,Payam Baziyar et al.
Nazanin Soleimanifard et al.
Protein misfolding has been reported as a common symptom in many neurodegenerative diseases, leading to the formation of protein aggregates. Metal ions (holo form) are critical for the folding and function of WT-SOD1, whereas their absence ...
Astaxanthin Suppresses Amyloid-Beta-Induced Toxicity in AD Transgenic Caenorhabditis elegans via Promoting Skn-1-Dependent Proteasomal Activity [0.03%]
虾青素通过促进Skn-1依赖的蛋白酶体活性抑制AB诱导的转基因线虫毒性作用
Jianhua Li,Weiju Sun,Xuelian Wang et al.
Jianhua Li et al.
Astaxanthin is a ketocarotenoid that exhibits a variety of bioactivities, including neuroprotection, but the detailed mechanisms by which astaxanthin exerts neuroprotection remain unclear. In the present study, the effects of astaxanthin on...
Role of Calcium in the Regulation of Chronic Stress-Induced Progression of Stress Granule Assembly in N2a Cells [0.03%]
钙在慢性压力诱导的神经母细胞瘤细胞中应激颗粒装配进程中的作用研究
Debasmita Saha,Saurabh Kumar,Rishikesh Kumar Gupta et al.
Debasmita Saha et al.
The persistence of stress granules (SGs) and subsequent pathological inclusion are implicated in neurodegeneration. Although SGs formed under acute stress have been well investigated, the role of biophysical factors in the formation of pers...
Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain [0.03%]
基于质谱成像的反义寡核苷酸组织分布研究及其在脑内的功能效应分析
Laura van der Vloet,Ronny Mohren,Christophe Bouillod et al.
Laura van der Vloet et al.
In recent years, the development of antisense oligonucleotides (ASOs) has gained wide interest as therapeutic agents for their potential in treating neurodegenerative diseases. ASOs are chemically modified oligonucleotides that are designed...
Lippia grata Schauer: Essential Oil and Phytoceutical Thymol Antioxidants and Neuroprotectors with Inhibition of Acetylcholinesterase and Depressive Behaviors in Adult Zebrafish (D. rerio) [0.03%]
Schauer苦橙薄荷(Lippia grata):其精油和植物药物丁香酚通过抗氧化和神经保护作用抑制斑马鱼(Acetylcholinesterase和Depressive行为在内的成年人的行为)
Luiz F Wemmenson G Moura,Maria Rayane C de Oliveira,Gabriela A do Nascimento et al.
Luiz F Wemmenson G Moura et al.
Depression, a growing mental disorder, affects millions of people globally and faces treatment challenges due to the low efficacy and adverse effects of conventional antidepressants. In this context, medicinal plants such as Lippia grata Sc...
Asparagine Deamidation Attenuates Toxicity, Aggregation, and Microglial Responses of Alzheimer's Amyloid-β [0.03%]
天冬酰胺脱氨可减轻阿尔茨海默病淀粉样蛋白-Aβ的毒性、聚集和小胶质细胞反应
Maria Sajimon,Christopher J Wheeler,Alejandro R Foley et al.
Maria Sajimon et al.
Alzheimer's disease (AD) is a growing global challenge that imposes a tremendous burden on society and economies. Though recently approved anti-amyloid β (Aβ) immunotherapies show effectiveness in clearing amyloid and slowing cognitive de...
HDAC6 as a Modulator of DNA Repair in Alzheimer's Disease: From Mechanisms to Therapeutic Perspectives [0.03%]
组蛋白去乙酰化酶6在阿尔茨海默病中的功能及机制研究：从机制到治疗前景
Aneesh Mazumder,Prasenjit Mondal,Can Zhang
Aneesh Mazumder
Double-strand breaks (DSBs) are the most cytotoxic DNA damages that arise from endogenous processes (oxidative metabolism as well as external stressors); unrepaired DSBs are consistently found in the hippocampus and cortex of Alzheimer's di...