G2019S LRRK2 Kinase Inhibition in Heterozygous Mice Avoids Lung Phenotype Observed with Inhibition of WT LRRK2 [0.03%]
2019冠状病毒病(LRRK2激酶抑制小鼠中的杂合性避免了WT LRRK2抑制所观察到的肺表型)
Albert W Garofalo,Marcus D Schonemann,Matteo Santoro et al.
Albert W Garofalo et al.
Gain-of-function mutations in the LRRK2 protein elevate kinase activity, and heterozygous or homozygous carriers of mutant LRRK2 have an increased risk of Parkinson's disease (PD), together suggesting that inhibition of mutant LRRK2 kinase ...
Modulating Stress Granules via HDAC6 Inhibition: A Promising Strategy against Alzheimer's Disease [0.03%]
通过HDAC6抑制调节应激颗粒：对抗阿尔茨海默病的一种有希望的策略
Emona Jagaselvan,Prasenjit Mondal,Can Zhang
Emona Jagaselvan
Emerging evidence suggests that dysregulated cellular stress responses, particularly the formation and persistence of stress granules (SGs), may significantly contribute to Alzheimer's disease (AD) pathogenesis. SGs are dynamic, membrane-le...
Decreased Sphingosine 1-Phosphate Levels in the Prefrontal Cortex of Mice Susceptible to Repeated Social Defeat Stress [0.03%]
易发生重复性社会挫败应激小鼠前额叶组织中鞘氨醇-1-磷酸水平的改变
Katsuya Morito,Suzumi Kimura,Saki Fujisawa et al.
Katsuya Morito et al.
Repeated psychological stress is a major risk factor for psychiatric disorders. Sphingosine 1-phosphate (S1P), a bioactive sphingolipid, is known to contribute to regulating central nervous system functions. However, the relationship betwee...
Microbes and Microbial Chemical Matter in the Seeding of Alzheimer's Disease: Prospects for Orthogonal Therapies [0.03%]
阿尔茨海默病的微生物及微生物化学物质“播种”假说：针对非对称疗法的前景
Naveen Kumar,Venkateswarlu Yarlagadda
Naveen Kumar
Alzheimer's disease (AD) remains the leading cause of dementia, with mortality rates having doubled over the past two to three decades and projected to rise with continued population aging. Despite its profound health and economic impact, e...
5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase [0.03%]
5-HT4受体配体RS67333通过抑制乙酰胆碱酯酶调节纹状体中乙酰胆碱和多巴胺的释放
Qinbo Qiao,Wenhui Wu,Stephanie J Cragg
Qinbo Qiao
Serotonin 5-HT4 receptors (5-HT4Rs) have emerged as potential therapeutic targets in neuropsychiatric and neurodegenerative disorders by modulating circuits that shape mood, cognition, and motor functions. Ligands for 5-HT4Rs can modify dop...
Alzheimer's Disease: A Review of Molecular Mechanisms and Interventions Targeting Aβ-Binding Receptors [0.03%]
阿尔茨海默病：分子机制及针对淀粉样蛋白-结合受体的干预措施综述
Mengke Jia,Jinfei Mei,Yvning Guan et al.
Mengke Jia et al.
In the pathogenesis of Alzheimer's disease (AD), the aggregation of Aβ peptides into Aβ oligomers (AβOs) plays a critical neurotoxic role. By binding to various cell membrane receptors, AβOs can trigger abnormal intracellular signaling ...
Emerging Promise of Sulforaphane in Autism: A Comprehensive Review of Its Therapeutic Potential and Mechanisms [0.03%]
萝卜硫素治疗自闭症的新兴潜力及机制综述
Xinming Zhang,Qi He,Yuan Yuan Zhu et al.
Xinming Zhang et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that emerges in early childhood and significantly impacts the quality of life for individuals and families. Currently, there are no specific medications available for A...
Development of Aryl Cyano Amides for Fluorescence Discrimination of Tau and Amyloid Beta Deposits in Tissue [0.03%]
用于组织中tau和淀粉样蛋白β斑块荧光鉴别的芳基氰胺酰胺的开发
R Erin Jessup,Rachel S Ehrlich,Kristine L Teppang et al.
R Erin Jessup et al.
The accumulation of amyloid aggregates such as amyloid beta (Aβ) and tau deposits in the brain is a hallmark of many neurodegenerative diseases including Alzheimer's disease. Recent advances in optical imaging have shown that fluorescent p...
PTEN Negatively Regulates Spastin Ser210 Phosphorylation To Modulate GluA1 Surface Trafficking and Excitatory Synaptic Transmission [0.03%]
PTEN通过调节Spastin Ser210磷酸化来调控GluA1表面递送及兴奋性突触传递
Danlei Liu,Jiagui Zhong,Laijian Wang et al.
Danlei Liu et al.
As a key component of the cytoskeleton, microtubule dynamics provide structural support for neurite growth. Spastin plays a critical role in reshaping microtubule arrangement, which is essential for axon development and regeneration. Howeve...
Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease [0.03%]
VU6081679的发现：一种新型的代谢型谷氨酸受体8变构激动剂及其帕金森病动物模型中的疗效研究
Alexa E Richardson,Anthony S Ferranti,Li Peng et al.
Alexa E Richardson et al.
Herein, we report a potent, CNS penetrant, orally bioavailable metabotropic glutamate receptor subtype 8 (mGlu8) positive allosteric modulator (PAM), VU6081679, that shows robust efficacy in a rodent model of Parkinson's disease. A high-thr...