The Synergistic Potential of Rationally Designed Phenol-Triazole Derivatives to Attenuate Aβ/Cu2+-Aβ Aggregation and Reactive Oxygen Species [0.03%]
合理设计酚基三唑衍生物协同抑制Aβ/Cu₂⁺-Aβ聚集和活性氧的潜力
Gagandeep Kaur,Opinder Kaur Mankoo,Amandeep Kaur et al.
Gagandeep Kaur et al.
Alzheimer's disease (AD) is a neurological disorder characterized by a spectrum of symptoms such as memory loss and cognitive decline. AD is a multifaceted disease, and designing multipotent ligands is an effective strategy for AD treatment...
ULK1 Knockout Exacerbates Ischemia-Induced Microglial Dysfunction via TRAF6/NF-κB Signaling Pathway [0.03%]
ULK1敲除通过TRAF6/NF-κB信号通路加剧缺血诱导的小胶质细胞功能障碍
Ye Xiong,Zhuo Li Li,Xiao Wan Wang et al.
Ye Xiong et al.
Activated microglia rapidly migrate to the infarct site, mediate neuroinflammation, and phagocytose cell debris during the acute stage of ischemic stroke; however, the underlying mechanisms remain unclear. In this study, we utilized a corti...
Exploring the Therapeutic Potential of Ar-tur in Alzheimer Disease: A Cheminformatics, Pharmacokinetics, and System Pharmacology Approach [0.03%]
基于化学信息学、药代动力学与系统药理学的石菖蒲治疗阿尔茨海默病潜力探索研究
Reiya Bosco Don Bosco,Johnson Retnaraj Samuel Selvan Christyraj,Jenif Leo Anandharaj et al.
Reiya Bosco Don Bosco et al.
Acquisition and consolidation of recognition memory involves dopaminergic activity, which is determined to be dysregulated in Alzheimer disease (AD). Aromatic turmerone (Ar-tur), one of the major bioactive components of Curcuma longa, has b...
Psychedelics, Spirituality, and Fundamentalism: A Brain Network Approach to Cognitive Flexibility and Rigidity [0.03%]
psychedelia，精神主义和原教旨主义：认知灵活性和僵化的脑网络方法
Anjian Yang,Xinyou Lv,Hongshuang Wang et al.
Anjian Yang et al.
This viewpoint reconceptualizes mysticism and fundamentalism as brain network disorders, with psychedelics like psilocybin, lysergic acid diethylamide, and N,N-dimethyltryptamine offering potential to modulate these states. By disrupting ri...
Investigation of Methylsulfonamide's Capability to Prevent Zn2+-Induced Aβ Peptide Aggregation Based on Zn2+ Coordination within the Zinc Binding Region of Aβ for Treatment of Alzheimer's Disease (AD) [0.03%]
基于Zn2+在Aβ金属结合区的配位研究甲磺酰胺防止Zn2+-诱导的Aβ肽聚集的能力以治疗阿尔茨海默病（AD）
Demet Ataman Sadık,Cemre Sare Cansız,Merve Turğut et al.
Demet Ataman Sadık et al.
There is no cure for Alzheimer's disease (AD) with the currently suggested therapies. Thus, designing and synthesis of new drugs for the treatment of Alzheimer's disease for safe and effective therapy have become an important task. Metal io...
Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization [0.03%]
nomilin通过上调TAX1BP1介导的微胶质细胞极化调控缓解小鼠神经炎症和抑郁样行为
Jiaqi Li,Zhiping Yang,Jie Zhao et al.
Jiaqi Li et al.
Nomilin is a limonoid compound that is found in citrus fruits. However, their functions remain to be further studied. The present study mainly analyzed the antineuroinflammation and antidepressive function of nomilin. The antidepressant and...
Knockdown SIRT6 Alleviates Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage through Inhibiting Ferroptosis by Promoting SMARCA2 Acetylation [0.03%]
SIRT6敲低通过促进SMARCA2乙酰化抑制铁死亡从而缓解蛛网膜下腔出血后的血脑屏障破坏
Li Lv,Long Zhang,Yan Wang et al.
Li Lv et al.
Ferroptosis has been identified as a mechanism underlying subarachnoid hemorrhage (SAH), attributed to blood-brain barrier (BBB) disruption. This study aimed to explore whether SIRT6 mediates ferroptosis affecting BBB disruption after SAH a...
Predicting Δ-9-Tetrahydrocannabinol-Induced Psychoactive and Cognitive Effects: A PBPK-PD Approach to Quantifying Feeling High and Reduced Alertness [0.03%]
基于PBPK-PD方法预测Δ-9-四氢大麻酚致精神病理和认知效应：量化“兴奋”和“警觉下降”的程度
Lixuan Qian,Zhu Zhou
Lixuan Qian
The increasing use of cannabis for medicinal and recreational purposes highlights the need to understand its psychoactive effects. Δ-9-tetrahydrocannabinol (THC), the primary psychoactive cannabinoid, is responsible for feeling high and re...
Aryl Guanyl Hydrazones: A Viable Strategy for Designing BBB-Permeable, Neuroactive Compounds? [0.03%]
脑渗透和神经活性化合物的设计的新策略：苯基瓜烷胲腙类化合物
Eleonora Colombo,Leonardo Maiorana,Greta Donati et al.
Eleonora Colombo et al.
Guanyl hydrazones are emerging as valuable, target-tunable functional groups. In particular, aryl guanyl hydrazones, owing to extensive conjugation with aromatic rings, exhibit lower pKa values compared to their aliphatic counterparts, so t...
Investigating the Interactions of a Cyclic Peptide Hormone Somatostatin and Its Derivatives on Amyloid-Beta Aggregation [0.03%]
环肽激素生长抑素及其衍生物抑制淀粉样蛋白聚集的相互作用机制研究
Amy Trinh Pham,Yusheng Zhao,Amy Oo et al.
Amy Trinh Pham et al.
We investigated the effects of cyclic peptides somatostatin, its isomer d-Trp8-somatostatin, and marketed somatostatin derivatives octreotide and lanreotide on Aβ42 aggregation and cytotoxicity in mouse hippocampal HT22 cells. The aggregat...