Pharmacokinetic Studies of Amyloid-Targeting Bis(styryl)benzene Agents for Alzheimer's Disease [0.03%]
针对阿尔茨海默病的淀粉样蛋白靶向联苯茋类药物的动力学研究
Kerui Xu,Jennifer A Salaiza,Hammed Adeoye et al.
Kerui Xu et al.
The pharmacokinetics (PK) and biodistribution of radiolabeled amyloid-β (Aβ)-targeting probes have been extensively characterized in the context of Alzheimer's disease (AD), whereas the corresponding nonradiolabeled scaffolds remain large...
Exploring the Neuroprotective Potential of 5-Azacytidine on the Streptozotocin-Induced Rat Model of Alzheimer's Disease [0.03%]
5-Azacytidine在链脲佐菌素诱导的阿尔茨海默病大鼠模型中的神经保护作用研究
Shivangi Paliwal,Jayant Singh Bhardwaj,Rajeev Taliyan
Shivangi Paliwal
Alzheimer's disease (AD) associated with insulin resistance represents a major challenge in sporadic neurodegeneration, where impaired neuronal survival and synaptic plasticity are compounded by aberrant DNA methylation. Epigenetic silencin...
Fluorescence Lifetime and Smartphone-Enabled Detection of Amyloid-β for Diagnosis and Staging in Alzheimer's Disease [0.03%]
用于阿尔茨海默病诊断和分期的淀粉样蛋白-β荧光寿命及智能手机检测技术
Krithi K Bhagavath,Madhu Ramesh,Yogendra Kumar et al.
Krithi K Bhagavath et al.
Alzheimer's disease (AD) is characterized by the pathological aggregation of amyloid-β (Aβ) peptides into plaques that drive neurodegeneration and cognitive decline. As Aβ remains the central and pathological biomarker for early and defi...
Phuong H Nguyen,Philippe Derreumaux
Phuong H Nguyen
Alzheimer's disease and related dementias affect more than 55 million people worldwide, a number projected to double by 2050 as populations age. Beyond the devastating personal toll on patients and families, the global economic burden is es...
Pathogenic Modulation of Organelle Crosstalk in Helicobacter pylori-Associated Neurodegeneration [0.03%]
幽门螺杆菌相关神经退行性疾病中的病原体调控的细胞器串话现象
Meenakshi Kandpal,Harshita Shrivastava,Nfor Gael Njini et al.
Meenakshi Kandpal et al.
Neurological disorders are increasingly linked to dysfunction of key cellular organelles, including mitochondria, endoplasmic reticulum (ER), lysosomes, endosomes, and peroxisomes. These organelles coordinate essential neuronal processes vi...
A High-Affinity NIR Fluorescent Probe for Aβ Oligomers Enables Theranostics Through Disrupting Membrane Interaction and Aggregation [0.03%]
一种高亲和力近红外荧光探针用于检测Aβ寡聚体并通过破坏膜相互作用和聚集实现诊疗一体化
Min Yang,Yuhan Wang,Jianhua Deng et al.
Min Yang et al.
Amyloid-β (Aβ) oligomers serve as pivotal biomarkers and therapeutic targets in Alzheimer's disease (AD) due to their early emergence in pathogenesis and high level of neurotoxicity. In this work, we introduce a class of D-π-A amphiphili...
Neuropeptide Diversity Encoded in Newly Sequenced Crustacean Genomes Reveals Signaling Roles during Feeding [0.03%]
新测序甲壳动物基因组中的神经肽多样性揭示了其在摄食过程中的信号作用
Lauren Fields,Vu Ngoc Huong Tran,Thao Duong et al.
Lauren Fields et al.
Neuropeptides are chemically diverse signaling molecules that regulate physiology and behavior, yet many species lack neuropeptidomic characterization due to sparse genomic annotation. Here, we integrate genomic sequence information with ne...
Iron Oxide Nanoparticles for Modulating Reactive Oxygen Species: Synthesis, Properties, and Therapeutic Applications in Disease Treatment [0.03%]
用于调节活性氧的氧化铁纳米颗粒：合成，性质及疾病治疗中的治疗应用
Yi-Bo Yuan,Miao-Miao Yin,Meng-Kang Jiang et al.
Yi-Bo Yuan et al.
Despite substantial advances in modern medicine, neurodegenerative diseases, chronic disorders, and cancers remain major clinical challenges in which dysregulated reactive oxygen species (ROS) play a critical role. Iron oxide nanoparticles ...
Short- and Long-Acting Psychedelics: Structure-Activity Relationships, Pharmacology, and Implications for Neuropsychiatric Therapeutics [0.03%]
短效和长效 psychedelics：结构活性关系，药理学及对神经精神药物治疗的启示
Anoushka Bhat,Elmira Zolali,Mahfuz A Sakib et al.
Anoushka Bhat et al.
Psychedelics have re-emerged as promising therapeutics for neuropsychiatric disorders, including depression, anxiety, post-traumatic stress disorder, and substance use disorders. While their beneficial effects are largely attributed to sero...
PET Molecular Probes for Neuroinflammation in Neurodegenerative Diseases: Progress and Prospects [0.03%]
神经退行性疾病中神经炎症的正电子发射断层显像分子探针：进展与前景
Hongjun Jin
Hongjun Jin
Neuroinflammation is a central pathological process underlying neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis. Positron emission tomography (PET) molecular probes now ...