Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity [0.03%]
日本脑炎病毒免疫减弱会加重登革热病情
Sidharth Malhotra,Birendra P Gupta,Surendra Uranw et al.
Sidharth Malhotra et al.
Owing to increased global movement, vector-spread permissive climate change, and increased vaccination coverage against certain flaviviruses, the likelihood of being exposed to multiple flaviviruses in a lifetime has increased. Although man...
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins [0.03%]
针对新型冠状病毒祖先毒株和XBB.1.5刺突蛋白的XB.1.5新冠疫苗可诱导持久的抗体反应
Sanjeev Kumar,Shilpi Jain,Bushra Wali et al.
Sanjeev Kumar et al.
The rapid emergence of divergent SARS-CoV-2 variants led to a 2023-2024 update of the COVID-19 mRNA vaccine to a monovalent version containing the XBB.1.5 SARS-CoV-2 spike antigen. To determine the durability and breadth of the antibody res...
High-throughput synthesis and specificity characterization of natively paired influenza hemagglutinin antibodies with oPool+ display [0.03%]
用于表征天然配对流感血凝素抗体特异性的高通量oPool+显示技术
Wenhao O Ouyang,Huibin Lv,Wenkan Liu et al.
Wenhao O Ouyang et al.
Antibody discovery is crucial for developing therapeutics and vaccines and for understanding adaptive immunity. However, the lack of approaches to synthesize antibodies with defined sequences in a high-throughput manner represents a major b...
An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer [0.03%]
一种无等位基因特异性的靶向抑制KRAS突变的小分子化合物能抑制胰腺癌的肿瘤维持信号并重编程免疫系统
Kathleen M McAndrews,Francesca Paradiso,Clint A Stalnecker et al.
Kathleen M McAndrews et al.
KRAS is among the most frequently mutated oncogenes in cancer, and for decades, efforts at pharmacological blockade of its function in solid cancers have been unsuccessful. A notable advance in this endeavor is the recent development of sma...
Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project [0.03%]
肿瘤基因组图谱计划全基因组测序样本中的微生物综合分析
Yuchen Ge,Jennifer Lu,Daniela Puiu et al.
Yuchen Ge et al.
In recent years, a growing number of publications have reported the presence of microbial species in human tumors and mixtures of microbes that appear to be highly specific to different cancer types. Our recent reanalysis of data from three...
Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension [0.03%]
抑制SLC38A2可降低高血压小鼠模型的血压
Chunxiu Du,Hu Xu,Wenqian Zhao et al.
Chunxiu Du et al.
Hypertension remains a major global health burden with limited effective treatment options. In the present study, the sodium-dependent neutral amino acid transporter SLC38A2 was identified as a regulator of blood pressure (BP) through modul...
Abraham Gihawi,Henry M Wood,Jeremy Clark et al.
Abraham Gihawi et al.
Oncomicrobes are estimated to cause 15% of cancers worldwide. When cancer whole-genome sequencing (WGS) data are collected, the microbes present are also sequenced, allowing the investigation of potential etiological and clinical associatio...
NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors [0.03%]
NF1缺失的ER阳性乳腺癌对CDK4/6抑制剂敏感性不同
Ze-Yi Zheng,Anran Chen,Eric J Jaehnig et al.
Ze-Yi Zheng et al.
Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase-activating protein and estrogen receptor (ER) transcriptional corepressor. NF1low status, identified by copy number loss or low mRNA/protein expression, is associated with endocrine ther...
Periadventitial delivery of mesenchymal stem cells improves vascular remodeling and maturation in arteriovenous fistulas [0.03%]
间充质干细胞的peri adventitial递送可改善动静脉瘘的血管重塑和成熟度
Sreenivasulu Kilari,Randall R DeMartino,Scott L Nyberg et al.
Sreenivasulu Kilari et al.
Worldwide, more than 4 million patients with end-stage kidney disease require hemodialysis through an arteriovenous fistula (AVF). AVFs fail because of venous neointimal hyperplasia (VNH) resulting in venous stenosis formation. A phase 1 ra...
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation [0.03%]
通过刺激HSC依赖性细胞外基质降解来解决纤维化问题
Sachin Sharma,Vijaya Prathigudupu,Carson Cable et al.
Sachin Sharma et al.
Tissue fibrosis arises from a critical imbalance between the production and breakdown of extracellular matrix (ECM) components. Whereas current strategies predominantly focus on curbing ECM production, the possibility of promoting ECM degra...