NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors
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Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase-activating protein and estrogen receptor (ER) transcriptional corepressor. NF1low status, identified by copy number loss or low mRNA/protein expression, is associated with endocrine therapy resistance in ~2... ...
