USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts [0.03%]
USP5抑制通过泛素介导的AML1-ETO降解在患者来源异种移植瘤中使t(8;21)急性髓系白血病治疗成为可能
Lan Ma,Kun Zhang,Zixuan Zhang et al.
Lan Ma et al.
The AML1-ETO (AE) fusion protein is a key target for treating t(8;21) acute myeloid leukemia (AML). In this investigation, we identified ubiquitin-specific protease 5 (USP5) as the deubiquitinating enzyme of AE. USP5 knockdown decreased AML...
Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion [0.03%]
人胰腺导管腺癌的空间分析揭示了与静脉侵犯相关的分子改变
Alexander T F Bell,Peter Chianchiano,Katsuya Hirose et al.
Alexander T F Bell et al.
In pancreatic ductal adenocarcinoma (PDAC), venous invasion (VI) is a critical step in metastasis and is associated with poor survival. However, little is known about the molecular features of VI. To investigate, we performed spatial transc...
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice [0.03%]
视网膜多不饱和脂肪酸补充可逆转小鼠年龄相关性视力下降
Fangyuan Gao,Emily Tom,Cezary Rydz et al.
Fangyuan Gao et al.
The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), primarily localized in cell membranes, where they govern membrane biophysical properties. During aging, alterations in lipid metabolism lead to reduced content of very ...
Afucosylation of anti-dengue IgG is associated with enhanced susceptibility to dengue virus infection postvaccination [0.03%]
疫苗接种后抗登革热IgG的去岩藻糖基化与登革病毒再感染易感性增强有关
Usama Ashraf,Saborni Chakraborty,Courtney Scallan et al.
Usama Ashraf et al.
Dengue viruses (DENVs) cause 390 million infections annually, although only ~25% of these infections are symptomatic. Whereas antibody features linked to severe DENV disease are well studied, factors influencing infection susceptibility rem...
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation [0.03%]
系统性炎症和T细胞及B细胞功能障碍决定易感个体向类风湿关节炎的发展方向
Ziyuan He,Marla C Glass,Pravina Venkatesan et al.
Ziyuan He et al.
Rheumatoid arthritis (RA) is preceded by an at-risk stage of disease that can be marked by the presence of anticitrullinated protein antibodies (ACPAs) but the absence of clinically apparent synovitis (clinical RA). Preemptive intervention ...
CAR T cell-mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis [0.03%]
CAR-T细胞介导的骨髓炎症导致血液毒性和有利于克隆造血
Myriam Ben Khelil,Ahmadreza Arbab,Janesa Srikanthan et al.
Myriam Ben Khelil et al.
Although chimeric antigen receptor (CAR) T cells have shown excellent results in treating hematological malignancies, they also cause side effects. Patients treated with CAR T cells experience persistent cytopenia or hematotox. Here, using ...
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles [0.03%]
性别差异与HIV-1库细胞选择相关并导致固有免疫谱型改变
Toong Seng Tan,Ce Gao,Alexander S Hochroth et al.
Toong Seng Tan et al.
HIV-1 persistence despite suppressive antiretroviral therapy (ART) is primarily because of infected memory CD4 T cells, so-called viral reservoir cells, that harbor chromosomally integrated viral DNA as a "provirus" and resist clearance by ...
PD-1-targeted cis-delivery of an IL-2 variant induces a multifaceted antitumoral T cell response in human lung cancer [0.03%]
人源肺癌模型中PD-1介导的细胞内递送IL-2突变体诱导多功能抗肿瘤T细胞应答
Irene Fusi,Clara Serger,Petra Herzig et al.
Irene Fusi et al.
Antibody-cytokine fusion proteins are being developed as next-generation cancer immunotherapies, aiming to deliver activation signals to targeted immune populations. Among these, PD1-IL2v-an engineered interleukin-2 variant (IL-2v) lacking ...
Hippocampal spreading depolarization as a driver of postictal ambulation [0.03%]
海马扩散去极化作为阵发性游走的驱动因素
Bence Mitlasóczki,Adrián Gutiérrez Gómez,Midia Kamali et al.
Bence Mitlasóczki et al.
Postseizure (postictal) symptoms are regularly encountered in epilepsy and can be life threatening, yet their neurobiological underpinnings remain understudied. Using two-photon or widefield imaging, field potential and unit recordings, opt...