DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis [0.03%]
DeepHeme：一种高性能、通用的深度集成方法，用于骨髓形态计量和血液学诊断
Shenghuan Sun,Zhanghan Yin,Jacob G Van Cleave et al.
Shenghuan Sun et al.
Cytomorphological analysis of the bone marrow aspirate (BMA) is pivotal for the diagnostic workup of a broad range of hematological disorders. However, this skill is error prone, highly complex, and time consuming. Deep learning-based model...
Targeted suppression of glioma by ultralow-dose x-ray-induced photodynamic therapy and gold-based nanoclusters in preclinical models [0.03%]
基于超低剂量X射线诱导的光动力疗法和金基纳米团簇的小胶质细胞靶向治疗（前期模型）
Shi Li,Shileng Chen,Yimin Li et al.
Shi Li et al.
The diffuse and infiltrative nature of high-grade gliomas poses ongoing challenges in treatment and management. Radiotherapy is an important glioma treatment, with a standard radiotherapy dose of 60 gray. However, high-dose radiotherapy is ...
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates [0.03%]
非人灵长类动物接种未经稳定的SARS-CoV-2刺突mRNA疫苗可诱发广谱中和抗体
R Dilshan Malewana,Victoria Stalls,Aaron May et al.
R Dilshan Malewana et al.
Immunization with messenger RNA (mRNA) or viral vectors encoding spike protein with diproline substitutions (S-2P) were shown to provide protective immunity, curbing the COVID-19 pandemic. However, in light of the emergence of severe acute ...
Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression [0.03%]
蛋白质组特征分析表明，脂滴生成可促进食管鳞状细胞癌的发展
Zhaoyu Qin,Dongxian Jiang,Zihan Yu et al.
Zhaoyu Qin et al.
Esophageal cancer is one of the most common cancers and a leading cause of cancer-related mortality in the world. Here, we have performed comprehensive characterization of genetic, transcriptomic, proteomic, and phosphoproteomic features in...
AMPAR inhibition lowers S1P in human blood and improves murine autoimmune neuroinflammation by blocking T cell egress from lymph nodes [0.03%]
AMPAR抑制可降低人体血液中的S1P水平并通过阻断淋巴结中T细胞的输出来改善小鼠自身免疫性神经炎症反应
Beatrice Wasser,Manuela Ecker,Nicholas Hanuscheck et al.
Beatrice Wasser et al.
Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated signaling in neurons acts through regulation of ion channels. In T cells, we uncovered a noncanonical AMPAR-mediated metabotropic Gi protein-coupl...
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans [0.03%]
胚系编码的对花生的识别决定了人类收敛型抗体的发展
Orlee Marini-Rapoport,Léna Andrieux,Tarun Keswani et al.
Orlee Marini-Rapoport et al.
Humans develop immunoglobulin G (IgG) antibodies to the foods they consume. In the context of food allergy, allergen-specific IgG antibodies can sequentially class-switch to pathogenic IgE. However, the mechanism underlying the antigenicity...
Karin Pelka
Karin Pelka
Multicellular networks shape immune responses in solid tumors and inform improved immunotherapies.
Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers [0.03%]
NR2F2抑制使内分泌耐药性乳腺癌恢复对激素治疗的敏感性
Yanyan Cai,Peihua Zhao,Fan Wu et al.
Yanyan Cai et al.
Endocrine resistance is frequently encountered in estrogen receptor-positive (ER+) breast cancer, often because of somatic mutations such as neurofibromin 1 (NF1) loss. The mechanisms by which ER-directed proliferation is lost in such cases...
Andrew T Hale,Blake Zhou,Arjun Rajan et al.
Andrew T Hale et al.
Hydrocephalus (HC) is a failure of brain and cerebrospinal fluid (CSF) homeostasis often associated with dilation of the CSF-filled ventricles (ventriculomegaly). Hallmarks of HC include aberrant CSF dynamics, neural stem cell dysfunction r...
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors [0.03%]
甲氨蝶呤发挥抗肿瘤免疫作用并改善实体瘤患者免疫治疗的临床疗效
Ruirui Yang,Bei Wang,Zhaoming Su et al.
Ruirui Yang et al.
Low-dose methotrexate (MTX) is the first-line drug for treating rheumatoid arthritis as an immunosuppressor. We have identified that low-dose MTX exhibits antitumor immune activity. MTX treatment reduced tumor metastasis and enhanced the ef...