Twin-arginine transport complex plays an essential role in Caulobacter cell shape and viability [0.03%]
双精氨酸转运复合物在Caulobacter细胞形态和活力中起重要作用
Trisha N Chong,Klara Christensen,Damion L Whitfield et al.
Trisha N Chong et al.
Two main pathways are responsible for protein secretion across the cytoplasmic membrane in prokaryotes. While the general secretory (Sec) pathway transports proteins across the membrane in an unfolded state, the twin-arginine translocation ...
Epithelial-Dermal Inflammasome Crosstalk in Cutaneous Squamous Cell Carcinoma [0.03%]
表皮-真皮炎症小体对话在皮肤鳞状细胞癌中的作用
Ruochong Wang,Kush R Patel,Raphael R Shu et al.
Ruochong Wang et al.
Epithelia maintain their barrier function through the proliferative and plastic behavior of stem cells that drive continuous tissue regeneration. However, these same properties render epithelia susceptible to tumorigenesis. The skin, the la...
A shared binding interface controls Vps13 organelle-specific targeting independently of its vacuolar protein sorting function [0.03%]
共享的结合界面独立于Vps13的囊泡蛋白分选功能控制其器官特异性定位
Kevin Ryan Jeffers,Samantha Katarzyna Dziurdzik,Michael Davey et al.
Kevin Ryan Jeffers et al.
Yeast vacuolar protein sorting 13 (Vps13) is a bridge-like transporter that directs lipid flow between membranes at organelle contact sites. Vps13 targeting relies on organelle-specific adaptors containing proline-X-proline (PxP) motifs, wh...
Rab4 spatially and functionally converges with Rab7 in the degradative endolysosomal network [0.03%]
Rab4与降解性内溶酶体网络中的Rab7在空间上和功能上相收敛
Stephen M Farmer,Shiyu Xu,Yue Yu et al.
Stephen M Farmer et al.
Rab GTPases are key regulators of endosomal trafficking in eukaryotes. In mammalian cells, Rab4 and Rab7 were shown to localize to distinct compartments, with Rab4 on early endosomes for fast recycling and Rab7 on late endosomes for degrada...
The LINC complex and microtubule motors regulate the number and position of nuclei in the subperineurial glial cells of the Drosophila blood-brain barrier [0.03%]
LINC复合物和微管马达调节果蝇血脑屏障中的次神经周胶质细胞核的数量和位置
Olivia R Annes,Anton Schmitt,Daniel B Akinremi et al.
Olivia R Annes et al.
Syncytia provide a unique system in which to understand the mechanisms of cellular organization. Two dramatic features of syncytial cells are the number of nuclei and the positioning of nuclei within a shared cytoplasm. Whether the formatio...
Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties [0.03%]
通过调节膜机械性能对非经典浆膜铜转运蛋白CTR1的调节作用
Subhendu K Chatterjee,Sumanta Kar,Siddhanta V Nikte et al.
Subhendu K Chatterjee et al.
We describe a non-canonical, membrane receptor-like regulation of the human copper transporter CTR1 in response to copper stimuli. CTR1 is the sole high-affinity trimeric plasma-membrane copper-importing channel that self-regulates by under...
Eric N Bunker,Tara D Fischer,Peng-Peng Zhu et al.
Eric N Bunker et al.
Activation of the cGAS-STING pathway stimulates innate immune signaling as well as LC3B lipidation and ubiquitylation at Golgi-related vesicles upon STING trafficking. Although ubiquitylation at these subcellular sites has been associated w...
ZNF787 recognizes the core sequence of MIR element to regulate gene expression [0.03%]
锌指蛋白ZNF787通过识别MIR核心序列调控基因表达
Lingling Liao,Haining Zhou
Lingling Liao
Zinc finger (ZNF) proteins are widely studied as DNA-binding transcriptional regulators, yet many remain functionally uncharacterized-particularly in the context of repetitive genomic regions. Here, we report that ZNF787 specifically binds ...
A new subset of mitochondrial-derived vesicles perform inter-mitochondrial communications [0.03%]
一类新的线粒体衍生囊泡执行线粒体间的通讯功能
Priyanka Adla,Vani Bshivakumar,Dheeraj Pathak et al.
Priyanka Adla et al.
Mitochondria have a fascinating array of tools in their armory for maintaining cellular homeostasis, of which the formation of Mitochondrial-Derived Vesicles (MDVs) is the least energy-intensive. MDVs have become the 'go-to' vesicles for mi...
Baichun Niu,Xuguang Jiang,Masahide Kikkawa
Baichun Niu
Motor protein tails, long considered flexible and disordered linkers that mediate transient cargo interactions, are increasingly recognized as dynamic hubs containing context-dependent structural motifs. Advances in cryo-EM single-particle ...