Csf1 facilitates adaptive membrane lipid remodeling linked to ER-plasma membrane contact sites [0.03%]
Csf1促进与内质网-细胞膜接触位点相连的适应性膜脂重塑
Fumiyoshi Abe,Tetsuo Mioka,Yusuke Suzuki et al.
Fumiyoshi Abe et al.
Membrane lipid composition must be dynamically adjusted to preserve bilayer physical properties, yet the cellular mechanisms that support bulk lipid remodeling under physical stress remain incompletely understood. Here, we identify Csf1 as ...
Differential effects of tropomyosin paralogs on mitochondrial dynamics in Saccharomyces cerevisiae [0.03%]
酿酒酵母中同源丝肌动蛋白对线粒体动力学的不同作用
Freya Cardozo,Aakansha Paliwal,Adwaita Bose et al.
Freya Cardozo et al.
The actin cytoskeletal network is closely associated with mitochondria and performs crucial functions in mitochondrial movement, inheritance, and fission-fusion. Although its role in mitochondrial division is established, the specific contr...
Mutating different α-tubulin acetylation sites has distinct effects on axon terminal morphogenesis in Drosophila melanogaster [0.03%]
果蝇α-微管蛋白乙酰化不同位点对轴突终末形态发生的影响不同
Helen Than,Chloe J Welch,Ethan Schauer et al.
Helen Than et al.
Microtubules are created from uniform α- and β-tubulin building blocks but typically carry out a variety of specialized functions within a cell. The post-translational modification of tubulin is one means by which microtubule function can...
Novel KIF22 Variants Disrupt Mitosis in Human Chondrocytes and Expand SEMDJL2 Mechanisms [0.03%]
新的KIF22变异破坏人软骨细胞有丝分裂并扩展SEMDJL2机制
Amila Šemić,Kazette Yuen Yu Chan,Pricila Bernardi et al.
Amila Šemić et al.
Spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2) is a rare skeletal disorder caused by pathogenic variants in KIF22, a mitotic chromokinesin that generates polar ejection forces (PEFs) to ensure proper chromosome alignme...
Functions and trafficking mechanisms of RIC-8 in C. elegans and mammalian cilia [0.03%]
RIC-8在秀丽隐杆线虫和哺乳动物纤毛中的功能及其转运机制研究进展
Christina M Campagna,Abigail E Descoteaux,Abigail Poole et al.
Christina M Campagna et al.
Primary cilia exhibit conserved organization and contain structural and functional domains of unique molecular composition. The inversin compartment (InvC), which is found in the proximal ciliary segment of a subset of vertebrate and invert...
The C. elegans WASH complex supports epithelial polarity by promoting endosomal sorting of E-Cadherin [0.03%]
WASH复合体通过促进E-钙粘蛋白的内体分拣来支持秀丽隐杆线虫上皮极性
Patricia Irizarry-Barreto,Jennifer Smolyn,Victoria Brown et al.
Patricia Irizarry-Barreto et al.
Epithelial polarity requires polarized distribution of the apical adhesion complex that connects cells through the E-Cadherin transmembrane protein. E-Cadherin is intimately linked to the actin cytoskeleton through alpha catenin, which dire...
A spatial and temporal atlas of tubulin isotype gene expression during vertebrate embryonic development [0.03%]
脊椎动物胚胎发育过程中微管蛋白同种型基因时空图谱
Camilo V Echeverria,Raneesh Ramarapu,Nancy Diaz Batista et al.
Camilo V Echeverria et al.
Epithelial-to-mesenchymal transitions (EMT) require extensive cytoskeletal remodeling to enable changes in cell polarity, adhesion, and migration. Although transcriptional programs controlling EMT are well characterized, how microtubule com...
The phosphoenolpyruvate phosphotransferase system regulates cell length and width through semi-independent pathways [0.03%]
焦磷酸酶转移系统通过半独立途径调节细胞长度和宽度
Jacob Surber,Randy Morgenstein
Jacob Surber
It has been known for over 80 years that bacterial cell size is affected by growth conditions. Cells grown in nutrient rich medium are larger and wider than those grown in nutrient poor medium. Yet even after decades of research it is still...
Suresh Subramani,Richard Rachubinski
Suresh Subramani
Since the first report of peroxisomes as distinct "microbodies" in the proximal tubule cells of mouse kidney (Rhodin, 1954) and their biochemical identification as sites of hydrogen peroxide (H₂O₂) production and degradation (De Duve and ...
AP-3 and the V-ATPase Modulate CTP Synthase Assembly Through Spatial Association at the Yeast Vacuole [0.03%]
AP-3和V-ATP酶通过空间关联在酵母液泡中调节CTPS组装
Michaela McCright,Mitchell Leih,Ayla Nack et al.
Michaela McCright et al.
The compartmentalization of metabolic enzymes into membraneless filaments termed cytoophidia represents a conserved regulatory mechanism, exemplified by cytidine triphosphate synthase (CTPS), which assembles into pH-sensitive cytoophidia in...