The identification of drp1 patient mutations that limit interactions with mff [0.03%]
识别限制与MFF相互作用的Drp1患者突变体
Yuli Buckley,Anelise N Hutson,Brianna L Bauer et al.
Yuli Buckley et al.
Patient mutations within Drp1, the master regulator of mitochondrial fission, lead to severe neurological defects and poor patient outcomes. Many of these mutations have been characterized as causing functional or assembly defects in Drp1, ...
PES-8, a ZP-like protein, is required for Cytoskeletal Organization and Contractility in the C. elegans Spermatheca [0.03%]
PES-8（一种类似ZP的蛋白质）对于秀丽隐杆线虫精子贮囊的细胞骨架组织和收缩能力是必需的
Fereshteh Sadeghian,Erin J Cram
Fereshteh Sadeghian
Proper regulation of contraction and relaxation in biological tubes is essential for organismal function. In C. elegans, the spermatheca, composed of smooth muscle-like cells, undergoes repeated stretching and contraction as oocytes pass th...
Vimentin bridges scales to convert polarized cell locomotion into coordinated collective migration [0.03%]
波形蛋白通过桥接鳞片将极化细胞运动转化为集体迁移中的协调运动会
Sudheer Kumar Peneti,Satish Babu Morparthi,Clémence Thiant et al.
Sudheer Kumar Peneti et al.
Collective cell migration is central in development and disease. Vimentin is an intermediate filament protein expressed by epithelial cells at the edge of wounds where collective cell migration is most efficient. Yet, its functional role in...
Guarding the Integrity of Cell-Based Research: The Role of the ICLAC Register of Misidentified Cell Lines [0.03%]
守护基于细胞研究的纯洁性：iclac注册的误识细胞系的作用
Ralf Weiskirchen
Ralf Weiskirchen
Cell line misidentification and cross-contamination remain persistent challenges in biomedical research, undermining experimental validity and contributing to irreproducible findings. Despite increased awareness and the availability of auth...
Tet Trim-Away: A conditional rapid protein degradation system for Tetrahymena thermophila [0.03%]
Tet 基因删除系统：四膜虫中的条件型快速蛋白质降解系统
Gayatri L Dholakia,Alexander J Stemm-Wolf,Aaisha Anzar et al.
Gayatri L Dholakia et al.
Tetrahymena thermophila is a ciliated protist that has played pivotal roles in biological discovery. Functional studies of Tetrahymena proteins have largely relied on gene knockouts. Because protein depletion upon knockout typically spans m...
Centriolar satellites regulate CEP350 mRNA stability and centrosome amplification [0.03%]
中心体卫星调节CEP350 mRNA稳定性及中心体扩增
Abraham Martinez,Chad G Pearson
Abraham Martinez
Messenger RNAs (mRNAs) accumulate at centrosomes in mitosis and interphase, yet the mechanisms governing their localization and their functional significance remain poorly understood. Here, we identify a centriolar satellite - RNA-binding p...
Quantitative comparison of PI(3,5)P2 biosensors reveals SnxA is the most sensitive and unbiased [0.03%]
定量比较PI(3,5)P2荧光探针的性能并揭示Snx9是最敏感和无偏倚的探针
Tiernan Swayhoover,Claire C Weckerly,Gerald R V Hammond
Tiernan Swayhoover
PI(3,5)P2 is an endosomal lipid whose depletion is associated with a variety of pathologies such as neurodegenerative diseases. However, studying this lipid in physiological and disease models has been difficult due to the scarcity of the l...
Adventures through wonderland: the wild world of histone gene organization, evolution, and regulation in over 250 species [0.03%]
奇幻之旅：250多种生物组蛋白基因的组织、进化和调控的野生世界
Sisi Falcone,Pravrutha Raman,William Marzluff et al.
Sisi Falcone et al.
Histone proteins are critical for the compaction and organization of DNA. In eukaryotes, these proteins are typically encoded by a multigene family. Replication-dependent histones are highly conserved, both in their amino acid sequence and ...
A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1 [0.03%]
一种筛选参与集体细胞迁移和睾丸形态发生的粘着带蛋白的方法揭示了Rab GTP酶激活蛋白RN-tre和激酶Par-1的重要作用
Sarah E Clark,Siobhan C Morris,Joseph B Dordor et al.
Sarah E Clark et al.
Animal tissues have diverse architectures and cell behaviors across the epithelial-mesenchymal spectrum. Cell adhesion mediated by classical cadherins is foundational. Cadherins nucleate complexes of dozens of proteins connecting junctions ...