TEP-1, a glial thioester protein is required for cilia organization and intraflagellar transport in ensheathed sensory neurons in C. elegans [0.03%]
线虫感觉神经元中TEP-1（硫酯胶质蛋白）对纤毛组织和内闭塞运输的形成是必需的
Yumiko Oshima,Yaminisree Nagidi,Maya E Moorthy et al.
Yumiko Oshima et al.
Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is characterized by progressive degeneration of retinal photoreceptors. Traditional disease models suggest that defective repression of thioester protein...
Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles [0.03%]
TMEM16F介导的脂质转移调节细胞外囊泡的形成和释放
Trieu Le,Maria Eugenia Perez Collado,Yu Meng Li et al.
Trieu Le et al.
The ubiquitous and highly conserved programmed cell death pathways that are essential for tissue development and homeostasis are accompanied by distinct morphological alterations. Apoptotic cells undergo fragmentation that is concomitant wi...
Structuring of the yeast endolysosomal pathway by the Rab5 guanine nucleotide exchange factors Muk1 and Vps9 [0.03%]
Muk1和Vps9通过鸟苷核苷酸交换因子对酵母内溶酶体途径的构建作用
Alexandra Nesterova,Derek C Prosser,Robert-William Welke et al.
Alexandra Nesterova et al.
The endolysosomal pathway, with its interconnected endosomes and lysosomes, has key functions in cellular nutrient and ion uptake, metabolic adaptation, as well as protein and organelle turnover via autophagy. Rab5 GTPases are organelle ide...
Lipid Droplets are rigid and physically suppress phagocytosis, unless cell compression or stretching activates actomyosin [0.03%]
脂滴是刚性的，在细胞不被压缩或拉伸时可物理抑制吞噬作用，除非细胞受到压缩或拉伸以激活肌动蛋白-myosin激活
Michael P Tobin,Irena L Ivanovska,Steven H Phan et al.
Michael P Tobin et al.
As with many cell types, macrophages are sometimes filled with micron-sized lipid droplets (LD's), but effects on phagocytosis of other cells, particulates, and microbes remain unclear. Here, we show LD's re-structure the cytoskeleton but r...
Dissecting Cytoskeletal Crosstalk Through Reconstituted Actin-Microtubule Systems [0.03%]
通过重建的肌动蛋白-微管系统剖析细胞骨架交叉 talk
Md Amzadul Hoque Chowdhury,Rupesh Kandel,Dana N Reinemann
Md Amzadul Hoque Chowdhury
Actin filaments and microtubules are fundamental components of the cytoskeleton in eukaryotic cells, orchestrating cellular processes such as intracellular transport, migration, and division. Traditionally studied as distinct entities, grow...
Early lipid-mediated responses to hyperosmotic stress at the yeast vacuole [0.03%]
酵母液泡应对高渗压力的早期脂质介导反应
Kalaivani Saravanan,Patricia M Kane
Kalaivani Saravanan
In yeast, early adaptation to hyperosmotic stress involves organelle-based mechanisms, including synthesis of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P₂) in the endolysosomal system. This low-level signaling lipid drives vacuolar fra...
The Atg2-Atg18 complex interacts with the Atg1 complex to localize to the pre-autophagosomal structure in Saccharomyces cerevisiae [0.03%]
大肠杆菌中Atg2-Atg18复合物与Atg1复合物相互作用并定位于自噬小体起始结构
Yuri Yasuda,Kanae Hitomi,Nobuo N Noda et al.
Yuri Yasuda et al.
During autophagy induction in Saccharomyces cerevisiae, over twenty autophagy-related (Atg) proteins localize to the site of autophagosome formation to generate the pre-autophagosomal structure (PAS), where phase-separated condensates of th...
Wnt signaling is modulated by the buffer-like properties of cadherins [0.03%]
粘附分子Cadherin通过缓冲样性质调控Wnt信号通路
Lauren Schnitkey,Christin Anthony,Marina Cardó-Vila et al.
Lauren Schnitkey et al.
β-catenin is a critical effector of the Wnt pathway and a key component of the cadherin complex. Whether Wnt-regulated cytoplasmic β-catenin interacts with the cadherin-associated pool under physiological conditions is unclear. Using a ce...
Twin-arginine transport complex plays an essential role in Caulobacter cell shape and viability [0.03%]
双精氨酸转运复合物在Caulobacter细胞形态和活力中起重要作用
Trisha N Chong,Klara Christensen,Damion L Whitfield et al.
Trisha N Chong et al.
Two main pathways are responsible for protein secretion across the cytoplasmic membrane in prokaryotes. While the general secretory (Sec) pathway transports proteins across the membrane in an unfolded state, the twin-arginine translocation ...
Epithelial-Dermal Inflammasome Crosstalk in Cutaneous Squamous Cell Carcinoma [0.03%]
表皮-真皮炎症小体对话在皮肤鳞状细胞癌中的作用
Ruochong Wang,Kush R Patel,Raphael R Shu et al.
Ruochong Wang et al.
Epithelia maintain their barrier function through the proliferative and plastic behavior of stem cells that drive continuous tissue regeneration. However, these same properties render epithelia susceptible to tumorigenesis. The skin, the la...