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Characterization of Orsay virus replication intermediates in Caenorhabditis elegans reveals links to antiviral RNA interference

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Orsay Virus (OV) is a positive-sense, single-stranded RNA (+ssRNA) virus that naturally infects C. elegans intestines. Like other +ssRNA viruses, the OV-encoded RNA-dependent RNA polymerase (oRdRP) synthesizes complementary antigenome for use as template for a... ...