Diabetic Corneal Neuropathy Precedes and Is Associated With Diabetic Retinopathy [0.03%]
糖尿病性角膜神经病先于并伴有 diabetic retinopathy 发生
Chang Liu,Isabelle Xin Yu Lee,Can Can Xue et al.
Chang Liu et al.
Diabetic corneal neuropathy (DCN) and diabetic retinopathy (DR) are microvascular complications and share common pathophysiological mechanisms. However, the relationship between them remains poorly defined. In this cross-sectional study, we...
Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets [0.03%]
优化单细胞长读序列测序以增强胰岛中的异构体检测能力
Maria S Hansen,Christopher J Hill,Lori Sussel et al.
Maria S Hansen et al.
Alternative splicing is an essential mechanism for generating protein diversity by producing distinct isoforms from a single gene. Dysregulation of splicing that affects pancreatic function and immune tolerance has been linked to both types...
Integrating SMRT and Bulk RNA Sequencing With Metabolic Phenotyping to Examine Reduced Skeletal Muscle Mitochondrial Respiration in Type 2 Diabetes [0.03%]
结合代谢表型分析，利用SMRT和Bulk RNA测序检测2型糖尿病骨骼肌线粒体呼吸降低现象
Martin Schön,Daniel Oehler,Iryna Yurchenko et al.
Martin Schön et al.
Recent advances in RNA sequencing (RNA-seq) techniques allow the identification of tissue-specific alternative splicing and can thereby provide new insights into molecular mechanisms of energy metabolism. Full-length transcriptomics based o...
Urinary Dickkopf-3 Reveals Tubular Fibrosis and Hidden Progression in Diabetic Kidney Disease [0.03%]
尿液Dickkopf-3揭示糖尿病肾脏疾病的肾小管纤维化和隐匿进展
Ming-Cheng Lin,Shiuan-Chih Chen
Ming-Cheng Lin
Editorial
Diabetes. 2026 Jan 20;75(2):e1-e2. DOI:10.2337/db25-0992 2026
Down-Regulation of Hepatic PPA1 Protects Against Obesity by Elevating FGF21 Production via eIF2α Phosphorylation [0.03%]
肝PPA1低表达通过eIF2α磷酸化促进FGF21生成来对抗肥胖现象
Yue Sun,Jinfu Zhang,Yuanyuan Su et al.
Yue Sun et al.
Pyrophosphatase 1 (PPA1) is upregulated in livers of high-fat diet-induced obese mice and metabolic dysfunction-associated steatotic liver disease patients. Hepatic PPA1 deletion protects mice against high-fat diet-induced obesity and relat...
Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+ Levels Without Affecting Glucagon Secretion [0.03%]
α细胞线粒体磷酸烯醇式丙酮酸循环的氨基酸感受机制不影响胰高血糖素分泌而调节胞内钙离子水平
Erli Jin,Hannah R Foster,Evgeniy Potapenko et al.
Erli Jin et al.
Our studies identify a role for the α-cell phosphoenolpyruvate cycle in sensing amino acids under hypoglycemic conditions. Leucine, in the presence of glutamine, opposes alanine/arginine-stimulated Ca2+ influx and glucagon secretion. Pyruv...
GLP-1, Pancreatic β-Cells, and Insulin Secretion: What We Know and Where We Need to Go [0.03%]
GLP-1、胰岛β细胞和胰岛素分泌：我们所知与需要探索的方向
Éverton L Vogt,Alicia J Kowaltowski
Éverton L Vogt
GLP-1 and its analogs enhance insulin secretion, but the specific intracellular mechanisms in β-cells remain unclear. Key intracellular mediators including calcium, glutamate, γ-aminobutyric acid, serotonin, and urocortin-3 are modulated ...
Identifying Insulin Autoantibodies With Differential Risk in Type 1 Diabetes With a Novel Bridging ELISA [0.03%]
一种新型搭桥酶联免疫吸附试验在1型糖尿病中鉴定具有不同风险的胰岛素自身抗体
Xiaofan Jia,Caiguo Zhang,Kathleen Waugh et al.
Xiaofan Jia et al.
In global type 1 diabetes (T1D) population screening studies, there is an urgent need for a highly sensitive and specific insulin autoantibody (IAA) assay that can be implemented across multiple laboratories. This study aimed to develop and...
Paracrine Hormonal Signals From Islet α-Cells Regulate Microtubule Dynamics in β-Cells to Promote Insulin Secretion in Mouse and Human Islets [0.03%]
胰岛α细胞旁分泌激素信号通过调节β细胞的微管动力学促进小鼠和人类胰岛中的胰岛素分泌
Kung-Hsien Ho,Syed N Barmaver,Shannon E Gibson et al.
Kung-Hsien Ho et al.
The microtubule network in β-cells attenuates insulin secretion by pulling insulin secretory granules away from the plasma membrane. Thus, high-glucose-induced microtubule remodeling is required for robust glucose-stimulated insulin secret...
Long Duration of Type 2 Diabetes Drives Erythrocyte-Induced Vascular Endothelial Dysfunction: A Link to miRNA-210-3p [0.03%]
糖尿病病程驱动红细胞诱导血管内皮功能障碍：miRNA-210-3p的作用机制
Eftychia Kontidou,Aida Collado,Rawan Humoud et al.
Eftychia Kontidou et al.
Type 2 diabetes increases cardiovascular risk, with endothelial dysfunction playing a key role. Prolonged disease duration exacerbates cardiovascular risk, but the underlying mechanisms remain unclear. We previously demonstrated that red bl...