Rene van Tienhoven,Arnaud Zaldumbide
Rene van Tienhoven
From Methylation to Metabolism: Linking Molecular Layers in Diabetes Risk [0.03%]
从DNA甲基化到代谢：糖尿病风险的分子联系
Christy M Nguyen,Marcus Seldin
Christy M Nguyen
Hypothalamic Prostaglandins Facilitate Recovery From Severe Hypoglycemia but Exacerbate Recurrent Hypoglycemia in Mice [0.03%]
小鼠下丘脑前列腺素促进严重低血糖恢复但会加重反复性低血糖症状
Takashi Abe,Shucheng Xu,Yuki Sugiura et al.
Takashi Abe et al.
The hypothalamus monitors blood glucose levels and regulates glucose production in the liver. In response to hypoglycemia, glucose-inhibited (GI) neurons trigger counterregulatory responses (CRRs), which stimulate the release of glucagon, e...
Atherosclerotic Cardiovascular Risk Before and After Type 2 Diabetes Onset and the Roles of Ectopic Fat and Ethnic Variation: The 2025 Edwin Bierman Award Lecture [0.03%]
2 型糖尿病发病前后动脉粥样硬化性心血管风险及异位脂肪和种族差异的作用：2025 年 edwin bierman 讲座奖演讲
Naveed Sattar
Naveed Sattar
Atherosclerotic cardiovascular disease (ASCVD) risk begins increasing years before the clinical onset of type 2 diabetes, driven in part by ectopic lipid accumulation. Many individuals predisposed to diabetes often gain weight rapidly and h...
An Unexpected Journey Into Brown Fat Research for Metabolic Health: The 2025 Outstanding Scientific Achievement Award Lecture [0.03%]
出乎意料的代谢健康棕色脂肪研究之旅——2025年度杰出科学成就奖获奖演讲
Shingo Kajimura
Shingo Kajimura
For many years, brown adipose tissue (BAT) was primarily regarded as a "heat organ" for rodents. Over the past 15 years, however, research in this field has shifted significantly toward understanding of the role of BAT in metabolic health, ...
Genetic Variants Increasing TAS2R38 Bitter Taste Receptor Sensitivity Are Associated With Lower Postprandial Glycemia [0.03%]
与TAS2R38苦味受体敏感性增加的基因变异相关的餐后血糖降低
Julie E Gervis,Kenneth E Westerman,Joanne B Cole et al.
Julie E Gervis et al.
TAS2R38 is a bitter taste receptor that influences bitter taste perception and diet and is also found in intestinal L cells that store and secrete glucagon-like peptide 1 (GLP-1). Preclinical studies have linked TAS2R38 activation to postpr...
NUAK1 Promotes Diabetic Kidney Disease by Accelerating Renal Tubular Senescence via the ROS/P53 Axis [0.03%]
NUAK1通过ROS/P53轴加速肾小管衰老促进糖尿病肾脏疾病
Lei Guo,Peili Wu,Qing Li et al.
Lei Guo et al.
Diabetic kidney disease (DKD) progression involves intricate interactions among senescence, oxidative stress, inflammation, and fibrosis. This study systematically investigates the regulatory role and molecular mechanisms of NUAK1 in DKD pa...
F N U Ruchi,Michele Schiavon,Akhilesh Pandey et al.
F N U Ruchi et al.
Early postprandial glucagon concentrations are higher in type 1 diabetes (T1D) than in individuals with no diabetes (ND). To determine the cause, we infused stable [13C9, 15N1]glucagon before, during, and after a mixed meal in 16 ND and 16 ...
Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes [0.03%]
急性应激下神经调节血糖的机制研究——美国糖尿病协会资助项目报告
Sarah A Stanley
Sarah A Stanley
There is significant evidence that acute stress, a challenge to an organism's homeostasis, has dramatic effects on metabolic control. Acute stress impairs blood glucose control in people with both type 1 and type 2 diabetes. In addition, gr...