Metabolomics-Defined Subtypes of Prediabetes and Risk of Cardiovascular-Kidney-Metabolic Outcomes [0.03%]
基于代谢组学的糖尿病前期亚型及心血管-肾脏-代谢性结局风险
Fei Chen,Yang Zhang,Weihao Wang et al.
Fei Chen et al.
Previous studies have identified heterogeneity among prediabetes subgroups using clinical characteristics; however, biological and metabolic heterogeneity remains insufficiently captured. This study examined whether data-driven clustering b...
Vascular Regenerative Cell Flux in Diabetes: Mechanistic and Clinical Implications [0.03%]
糖尿病血管再生细胞通路的机制和临床意义
Fallon Dennis,Cole J Dennis,Adrian Quan et al.
Fallon Dennis et al.
Vascular regenerative cells, including endothelial precursor cells and hematopoietic progenitor cells, exhibit altered regenerative function in type 2 diabetes. Traditional definitions of endothelial precursor cells lack phenotypic specific...
The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions [0.03%]
免疫衰老、细胞衰老与1型糖尿病的交集：为未来干预铺平道路
Danay Saavedra,Rahul Mittal,Carlos Blaschke et al.
Danay Saavedra et al.
Immunosenescence, characterized by functional decline and altered phenotypes of immune cells with age, can disturb immune tolerance and promote autoreactive responses. Type 1 diabetes (T1D) has traditionally been viewed as a disease of immu...
Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice [0.03%]
小鼠脂肪组织棕榈酰化周转介导胰岛素抵抗和β细胞功能的维持
Guifang Dong,George Spyropoulos,Sangeeta Adak et al.
Guifang Dong et al.
Palmitoylation, the reversible modification of proteins by palmitate, is altered in diabetes. We inactivated acyl protein thioesterase-1 (APT1), a key palmitoylation cycling enzyme, in adipose tissue to study how fat affects systemic metabo...
Metabolic Blockade of Glycolysis Diminishes Autoreactive CD4 T-Cell Effector Responses in Type 1 Diabetes [0.03%]
糖酵解代谢阻断可抑制1型糖尿病自身反应性CD4+t效应细胞反应
Miranda D Chávez,Anna R Mahr,Heather M Wilkins et al.
Miranda D Chávez et al.
Our goal: limit glycolysis with 2-deoxyglucose (2-DG) in autoreactive CD4 T cells to delay spontaneous type 1 diabetes in NOD mice. Inhibition of glycolysis with 2-DG during autoreactive CD4 T-cell activation and differentiation decreased e...
Myeloid-Specific Heparanase Aggravates Insulitis in Type 1 Diabetes via Heparan Sulfate Fragment-Dependent Amplification of Macrophage Polarization [0.03%]
髓系特异性肝素酶通过肝素硫酸盐片段依赖的巨噬细胞极化放大作用加重1型糖尿病自身胰岛炎
Jia Zhang,Meiwei Li,Xiaohang Zhou et al.
Jia Zhang et al.
The role of the heparanase (HPSE)-heparan sulfate (HS) axis in type 1 diabetes remains incompletely defined. We examined whether myeloid-derived HPSE drives islet inflammation, how HS fragments influence macrophage polarization, and whether...
A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action [0.03%]
一种选择性Cul3泛素连接酶抑制剂通过双重增敏和促胰岛素作用缓解高血糖症
Lijie Gu,Lei Xiong,Mohammad Nazmul Hasan et al.
Lijie Gu et al.
Pan-neddylation inhibitors exhibit potent hypoglycemic effect. The target organs and mechanisms underlying the hypoglycemia effect of pan-neddylation inhibitors are incompletely understood. We found that inhibition of cullin 3 leads to a du...
Dual Modulation of Prostaglandin E2 Receptors EP3 and EP4 Protects β-Cell Mass in a Model of Aggressive Autoimmune Inflammation [0.03%]
在自身免疫性炎症模型中，双调制前列腺素E2受体EP3和EP4保护β细胞群大小
Juliann B Burkett,Jennifer Fuhr,Alexander C Falk et al.
Juliann B Burkett et al.
Modulation of prostaglandin E2 (PGE2) signaling improves β-cell health and survival. In this study, we examined whether these β-cell effects could be harnessed alongside known PGE2-mediated immunomodulation to ameliorate β-cell loss in a...
Tiffany T Terry,Eduardo D Gigante,Coralie M Alexandre et al.
Tiffany T Terry et al.
The molecular mechanisms by which primary cilia regulate energy homeostasis remain poorly understood. Here, we evaluated whether the ciliary GTPase ARL13B regulates energy homeostasis and whether its localization to cilia is required to con...
SIRT6 Deficiency Impairs Endothelial Integrity to Exacerbate Diabetic Atherosclerosis via Inhibiting Deacetylation-Dependent ZEB1 Degradation [0.03%]
SIRT6缺乏通过抑制去乙酰化依赖性ZEB1降解损害内皮完整性以加剧糖尿病动脉粥样硬化
Deqiang Yuan,Kangwei Wang,Fan Ping et al.
Deqiang Yuan et al.
SIRT6 downregulation in atherosclerotic vascular endothelial cells (ECs) is exacerbated under diabetic conditions, and EC-specific Sirt6 knockout aggravates diabetic atherosclerosis progression. EC-specific Sirt6 knockout aggravates atheros...