Phosphatidylserine Supplementation Improves Metabolic Liver Disease and Glycemic Control in the Presence of Suppressed Oxidative Glucose Metabolism [0.03%]
Li Dong,Sihan Lin,John Slavin et al.
Li Dong et al.
Type 2 diabetes and obesity are commonly accompanied by metabolic dysfunction-associated steatotic liver disease (MASLD), increasing the risk of developing metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. The early stag...
Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue [0.03%]
Jordan W Strober,Kasper W Ter Horst,Daeun Sung et al.
Jordan W Strober et al.
White adipose tissue (WAT) insulin resistance (IR) is a central feature of metabolic syndrome; however, data regarding defects in WAT insulin signaling in humans with IR is limited. To determine which defects in WAT insulin signaling are as...
Maternal Obesity Leads to Muscle Dysfunction via H19-Mediated Programming of Insulin-Like Growth Factor 2 Signaling [0.03%]
母体肥胖通过H19介导的胰岛素样生长因子2信号程序导致肌肉功能障碍
Sharmeen Islam,Xinrui Li,M D Nazmul Hossain et al.
Sharmeen Islam et al.
Forty-two percent of American women of childbearing age are obese, impacting offspring muscle and metabolism. The insulin-like growth factor 2 (IGF2) pathway is vital for muscle growth, but its regulation by maternal obesity (MO) remains un...
Profiling Associations Between IGHG-FCGR Ligand-Receptor Interactions and Disease Progression From Stage 1 and 2 to Stage 3 Type 1 Diabetes [0.03%]
IgG-FcγR配体-受体相互作用与1型糖尿病从1期和2期进展至3期的关联分析
Lue Ping Zhao,George K Papadopoulos,Jay S Skyler et al.
Lue Ping Zhao et al.
The primary objective of this study was to investigate whether ligand-receptor interactions (LRIs) between IGHG and FCGR gene products are associated with progression to type 1 diabetes (T1D). Using two completed clinical trials (DPT-1 and ...
Prolonged Semaglutide Treatment Reveals Stage-Dependent Changes to Feeding Behavior and Metabolic Adaptations in Male Mice [0.03%]
利拉鲁肽长期治疗小鼠可使小鼠摄食行为和代谢适应性产生阶段依赖性变化
Harsh Shah,Julio E Ayala
Harsh Shah
Glucagon-like peptide 1 receptor (GLP-1R) agonists have transformed obesity treatment, but weight loss responses to these drugs vary widely. Elucidating behavioral and metabolic phenotypes throughout GLP-1R agonist treatment could identify ...
Multiorgan Fibrosis and Risk of Type 2 Diabetes: Genetic and Observational Evidence Highlighting a Causal Role of Pancreatic Fibrosis [0.03%]
多器官纤维化与2型糖尿病风险：遗传和观察证据强调胰腺纤维化的因果作用
Masato Uchida,Hajime Yamazaki,Sihao Han et al.
Masato Uchida et al.
Pancreatic fibrosis has been proposed as a contributor to type 2 diabetes (T2D) by impairing islet function, but whether it plays a causal role remains unclear. We investigated this question using two complementary approaches. First, we per...
Effects of Marked Weight Loss Induced by Gastric Bypass Surgery or Low-Calorie Diet Alone on Postprandial Glucose Disposal in Type 2 Diabetes [0.03%]
胃旁路手术或单纯低热量饮食引起明显体重减轻对2型糖尿病餐后血糖处置的影响
Bettina Mittendorfer,Bruce W Patterson,J Christopher Eagon et al.
Bettina Mittendorfer et al.
We used a dual (intravenous and oral) glucose tracer protocol to evaluate rates of glucose appearance in the circulation, insulin-mediated glucose disposal (IMGD), and noninsulin-mediated glucose disposal (NIMGD) for 4 h after consumption o...
Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice [0.03%]
小鼠脂肪组织TGR5缺失通过减少脂联素分泌促进肝脂肪变性
Jiahui Li,Qinhui Liu,Yimin Xiong et al.
Jiahui Li et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and a...
MODY Is Prevalent in Later-Onset Diabetes and Has Potential for Targeted Therapy but Is Challenging to Identify [0.03%]
自身免疫性糖尿病在成人晚发糖尿病患者中盛行并具有治疗潜能但难以识别
Luke N Sharp,Uyenlinh L Mirshahi,Kevin Colclough et al.
Luke N Sharp et al.
Maturity onset diabetes of the young (MODY) can present after the age of 40 years, but its prevalence and clinical characteristics, and the utility of simple clinical features for selecting cases in this age group remain poorly defined. We ...
B Lymphocytes Impede Tregs to Erode Islet Tolerance in Type 1 Diabetes [0.03%]
B淋巴细胞阻碍调节性T细胞破坏1型糖尿病中的胰岛免疫耐受
Christopher S Wilson,Blair T Stocks,Alexander C Falk et al.
Christopher S Wilson et al.
B lymphocytes are thought to drive β-cell destruction in type 1 diabetes (T1D) by activating anti-islet T cells. However, the observation that autoreactive T-cell activation and disease progression can occur without B cells challenges this...