Cardioplegic Machine Perfusion of Hearts Donated after Circulatory Death [0.03%]
循环死亡供者心脏捐献的体外灌注心肌保护研究进展
Lars Saemann,Kristin Wächter,Anne Großkopf et al.
Lars Saemann et al.
We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the single-shot solutions HTK-N and Del Nido cardioplegia (DNC) on left-ventricular (LV) contractility and myocardial microcirc...
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation [0.03%]
缺氧通过ACSL4乳酰化促进铁死亡加重心肌缺血再灌注损伤
Jiannan Lv,Mingnan Yin,Hongwen Jin
Jiannan Lv
Myocardial ischemia/reperfusion injury (MIRI) worsens ischemic damage, with ferroptosis as a key mediator of this iron-dependent cell death. Lactylation, a novel epigenetic modification, remains poorly understood in MIRI-associated ferropto...
Circulating SLC17A5 as a Diagnostic Biomarker of Early Endothelial Dysfunction in Young Dyslipidemic Individuals [0.03%]
SLC17A5循环作为年轻血脂异常个体早期血管内皮功能障碍的诊断生物标志物
Shamima Akhtar,Komal Sagar,Milind P Hote et al.
Shamima Akhtar et al.
Diagnostic potential of sialin in identifying endothelial dysfunction is explored. 50 CAD patients, 50 young (20-35 years) dyslipidemic individuals (DLP), and 50 healthy controls (HC) were included in the study. HUVECs were stimulated with ...
The Use of the Medina Coronary Bifurcation Classification has Led to Confusion and Missing One Third of True Bifurcation Lesions. The Movahed Bifurcation Classification Should be the Preferred Classification as it Categorizes All True Bifurcation Lesions in One Simple Category B2 Lesions with Limitless Suffixes that Can be Added if Needed [0.03%]
Medina分类的使用造成了混乱且遗漏了三分之一的真实分叉病变。Movahed分叉分类应作为首选分类，因为其将所有真实分叉病变归类为一个简单的B2型病变，并可根据需要添加不限制的后缀类型
Mohammad Reza Movahed
Mohammad Reza Movahed
Characterization of Neutrophil Extracellular Traps in Acute Myocardial Infarction: A Translational Study [0.03%]
急性心肌梗死中性粒细胞胞外陷阱的特征：一项转化研究
Sergio Huertas-Nieto,Ana Moraga-Yébenes,Lydia Zamora-Pérez et al.
Sergio Huertas-Nieto et al.
Neutrophil extracellular traps (NETs) are implicated in thrombosis and inflammation during acute myocardial infarction (AMI), but their kinetics, local distribution, and clinical relevance remain unclear. We conducted a prospective study in...
Noelia Bellon Quinones,Ruggero Belluomo,Rio P Juni et al.
Noelia Bellon Quinones et al.
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, necessitating innovative therapeutic strategies. Long non-coding RNAs (lncRNAs) have emerged as regulators of gene expression, influencing various c...
Platelet Reactivity and Fibrin Clot-Strength as assessed by TEG in Patients with Atrial Fibrillation undergoing Percutaneous Coronary Intervention [0.03%]
经皮冠状动脉介入治疗患者的血小板反应性和TEG评估的纤维蛋白凝块强度（房颤患者）
Diona Gjermeni,Hannah Vetter,Sofia Szabó et al.
Diona Gjermeni et al.
Platelet reactivity (PR) in clopidogrel-treated patients undergoing percutaneous coronary syndrome (PCI) associates with ischemic and bleeding risk. The aim was to investigate the association of PR and global hemostasis with this risk in pa...
Diammonium Glycyrrhizinate Alleviated Myocardial Fibrosis Induced by Isoprenaline Via Modulation of STAT/Smad3 Pathway [0.03%]
甘草酸二铵通过STAT/smad3信号通路调节异丙肾上腺素诱导的心肌纤维化
Qiaofeng Zhou,Na Jiang,Shihuan Li et al.
Qiaofeng Zhou et al.
Myocardial fibrosis (MF) severely impairs the heart structure and function post-myocardial infarction. The study investigated the effectiveness and mechanism of diammonium glycyrrhizinate (DG) on ISO-induced MF. ISO-stimulated mouse cardiac...
Advances in Acute Myocardial Infarction (AMI) Diagnostics: Classical Biomarkers, Emerging Tools, and the Rise of Non-Invasive Sampling [0.03%]
急性心肌梗死（AMI）诊断进展：经典生物标志物、新兴工具及非侵入性取样方法的兴起
Desmond Chen Siong Sia,Hammad Mufti,Wei Hsum Yap et al.
Desmond Chen Siong Sia et al.
Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide, highlighting the need for improved diagnostic approaches. While cardiac troponins are the current gold standard, their reliability in early detection and in p...
Yosef Eshetie Amare,Roman Vuerich,Serena Zacchigna
Yosef Eshetie Amare
Vascular endothelial growth factor receptor 1 (VEGFR1) is a key regulator of endothelial function, angiogenesis, inflammation, and cardiomyocyte survival, with both beneficial and deleterious effects in cardiovascular disease. In this revie...