Nicotinamide Mononucleotide Ameliorates Myocardial Fibrosis in Diabetic Mice Possibly by Modulating SIRT3 to Deacetylate GSK3β and Thereby Reducing the Phosphorylation of Smad3 [0.03%]
烟酰胺单核苷酸通过调节SIRT3去乙酰化GSK3β从而减少Smad3磷酸化来改善糖尿病小鼠心肌纤维化的作用及机制研究
Zuowang Ma,Liyang Yao,Kai Zhang et al.
Zuowang Ma et al.
This study aims to investigate the therapeutic potential of NMN in alleviating type 2 diabetes-induced myocardial fibrosis.The experiment was comprised of control group, diabetic group, DM + NMN intervention group, and DM + NMN+3-TYP group....
Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis [0.03%]
运动预 conditioning 激活 AMPK-ACC 信号并减轻心肌缺血/再灌注诱导的铁死亡
Yuxiang Xu,Jie Tang,Chenyang Wu et al.
Yuxiang Xu et al.
Ferroptosis critically mediates myocardial ischemia/reperfusion (I/R) injury. Exercise training confers cardioprotection, but whether it protects against I/R-induced ferroptosis and the underlying mechanisms remain unclear. In this study, C...
Empagliflozin Improves Endothelial Function in an Ovariectomized Rat Model of Estrogen Deficiency [0.03%]
恩格列净可通过改善雌激素缺乏卵巢切除大鼠内皮功能障碍发挥作用
Amanina Athirah Mad Azli,Mohd Helmy Mokhtar,Amilia Aminuddin et al.
Amanina Athirah Mad Azli et al.
Cardiovascular disease risk increases after menopause, largely driven by estrogen deficiency-induced endothelial dysfunction. While sodium-glucose cotransporter 2 (SGLT2) inhibitors confer cardiovascular protection, their vascular effects u...
Timing and Duration of Prediabetic Metabolic Dysfunction Differentially Impact Cerebral Perfusion, Vascular Structure, and Behavior [0.03%]
糖尿病前期代谢紊乱的时机和持续时间对脑血流、血管结构和行为的影响不同
Annika Matthiesen,Stephanie DiLucia,Riley Feagle et al.
Annika Matthiesen et al.
Obesity is a major risk factor for metabolic dysfunction and cognitive decline, yet the influence of age of onset and sex on neurovascular outcomes remains unclear. We examined how the age at initiation and duration of diet-induced obesity ...
Exercise-Induced Regulation of LncRNAs: Mechanistic Insights and Clinical Translation in Cardiovascular Health [0.03%]
运动诱导的长链非编码RNA调节：心血管健康中的机制洞察和临床转化
Tao Gao,Li-Hua Yu
Tao Gao
While exercise training is an established cornerstone for the prevention and treatment of cardiovascular diseases (CVDs), the underlying molecular mechanisms remain incompletely understood. Recent studies have identified long non-coding RNA...
Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy [0.03%]
超越泵浦：解析脓毒症心肌病中的免疫代谢交叉 talk 和器官动力学
Guangfu Liu,Liya Hao,Junfeng Zhang et al.
Guangfu Liu et al.
Sepsis-induced cardiomyopathy (SICM) has traditionally been viewed as pump-centered contractile failure, but this paradigm fails to explain the clinical spectrum and recovery patterns. This review presents an integrative framework where imm...
Autoantibody-Based Models for the Diagnosis and Activity Assessment of Takayasu Arteritis [0.03%]
基于自身抗体的Takayasu动脉炎诊断及病情评估模型
Jianxiong Wu,Jing Cui,Fengjuan Li et al.
Jianxiong Wu et al.
The precise diagnosis and activity assessment of Takayasu arteritis (TA) remain challenging. Using a two-phase approach, we screened serum from 9 TA patients and 10 healthy controls via HuProt microarrays, identifying three novel autoantibo...
FOSL2 Regulates PANoptosis in Cardiomyocytes and Heart Failure Progression After Acute Myocardial Infarction by Promoting NLRP12 [0.03%]
FOSL2通过促进NLRP12在急性心肌梗死后调节心肌细胞的PANoptosis并延缓心力衰竭进展
Renlian Gu,Yan Sun
Renlian Gu
NLRP12 can induce PANoptosis, a novel form of inflammatory cell death. The research aimed to investigate the mechanisms of NLRP12 in regulating PANoptosis during postinfarction heart failure (HF). C57BL/6J mice were treated with AAV-shNLRP1...
Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation [0.03%]
微轴流泵对正常心脏冠脉血流动力学影响的实验研究
Tomoaki Ito,Keita Saku,Kenta Ohba et al.
Tomoaki Ito et al.
The effects of microaxial flow pump (mAFP) support on coronary flow (CF) are well characterized in failing hearts, but its impact on CF in normal hearts under different levels of left ventricular (LV) unloading remains unclear. Seven anesth...
Yunmeng Wang,Jiaqi Wang,Yawei Liu et al.
Yunmeng Wang et al.
Atrial fibrillation (AF) is a common arrhythmia with significant morbidity and mortality, making it essential to conduct in-depth research on its mechanisms and treatments. Animal models are important tools in AF research because they can r...