Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499 [0.03%]
深海真菌Scedosporium apiospermum FKJ-0499产生的酪醇茋及其新类似物对耳念珠菌临床分离株的抗真菌谱研究
Haruki Azami,Yoshihiro Watanabe,Kazunari Sakai et al.
Haruki Azami et al.
A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2...
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13 [0.03%]
来自放线菌Kitasatospora putterlickiae 10-13的新型抗生素生物合成前体precezomycin
Di Mao,Pengwei Yu,Naoya Shinzato et al.
Di Mao et al.
A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin (1), was isolated from culture broth of actinomycete Kitasatospora putterlickiae 10-13. The planar structure was determined by 1D/2D NMR and HR(ESI)MS data analyses,...
Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway [0.03%]
新的oligomycin衍生物作为替代肽聚糖生物合成途径的特异性抑制剂的识别
Shuhei Umetsu,Takeshi Tsunoda,Haruka Kiyanagi et al.
Shuhei Umetsu et al.
Peptidoglycan is an important macromolecule in bacterial cell walls to maintain cell integrity, and its biosynthetic pathway has been well studied. Recently, we demonstrated that some bacteria such as Xanthomonas oryzae, a pathogen causing ...
The potentiation activity of β-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus [0.03%]
苯并噁嗪衍生物和氧杂戊环对耐甲氧西林金黄色葡萄球菌β内酰胺类的增效活性
Masako Honsho,Aoi Kimishima,Akari Ikeda et al.
Masako Honsho et al.
Antimicrobial resistance (AMR) causes a global health threat and enormous damage for humans. Among them, Methicillin-resistant Staphylococcus aureus (MRSA) resistant to first-line therapeutic β-lactam drugs such as meropenem (MEPM) is prob...
Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp [0.03%]
肠道真菌Fusarium中抗真菌次级代谢产物的发现
Mingkai Zhang,Baosong Chen,Huanqin Dai et al.
Mingkai Zhang et al.
Intestinal fungi, which are important parts of the gut microbiota, have the ability to produce specialized metabolites that significantly contribute to maintaining the balance of the gut microbiota and promoting the health of the host organ...
Micrococcus lacusdianchii sp. nov., an attached bacterium inhibited by metabolites from its symbiotic algae [0.03%]
微小杆菌丹鸡汤瘤孢新种：受其共生藻类代谢物抑制的附生细菌
Le Wang,Yao Xiao,Wenxin Lai et al.
Le Wang et al.
A novel actinobacterial strain, designated as JXJ CY 30 T, was isolated from the phycosphere of Microcystis aeruginosa FACHB-905 (Maf) collected from Lake Dianchi, China. The strain was a Gram-stain-positive, aerobic and coccus-shaped actin...
Cephalosporin resistance, tolerance, and approaches to improve their activities [0.03%]
头孢菌素类抗生素的耐药性、耐受性和提高其作用活性的方法
Alison H Araten,Rachel S Brooks,Sarah D W Choi et al.
Alison H Araten et al.
Cephalosporins comprise a β-lactam antibiotic class whose first members were discovered in 1945 from the fungus Cephalosporium acremonium. Their clinical use for Gram-negative bacterial infections is widespread due to their ability to trav...
Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594 [0.03%]
来自澳大利亚真菌新种托拉攀 Batesia johnpittii MST-FP2594 的 Talcarpones A 和 B：双萘紫素衍生物代谢产物
Alastair E Lacey,Scott A Minns,Rachel Chen et al.
Alastair E Lacey et al.
Talcarpones A (1) and B (2) are rare bisnaphthazarin derivatives produced by Talaromyces johnpittii (ex-type strain MST-FP2594), a newly discovered Australian fungus, which is formally described and named herein. The talcarpones were isolat...
TNF-α-induced down-regulation of type I interferon receptor contributes to acquired resistance of cervical squamous cancer to Cisplatin [0.03%]
肿瘤坏死因子α通过下调I型干扰素受体诱导宫颈鳞状细胞癌获得性顺铂耐药
Yani Yu,Jia Yu,Xiaorong Cui et al.
Yani Yu et al.
We aimed to investigate the effects of tumor necrosis factor (TNF)-α on the expression of interferon α/β receptor subunit 1 (IFNAR1) and cervical squamous cancer (CSCC) resistance to Cisplatin, as well as the underlying mechanisms. Kapla...
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022 [0.03%]
希腊一项2014至2022年调查的结果：新冠疫情前后尿道生殖器支原体和解脲支原体的抗微生物药物耐药率
Karolina Akinosoglou,Aristotelis Tsiakalos,Ioanna D Dimopoulou et al.
Karolina Akinosoglou et al.
The prevalence of antibiotic-resistant urogenital mycoplasmas and ureaplasmas has been gradually increasing over the years, leading to greater concern for accurate diagnosis and treatment. In this study, the antimicrobial resistance trends ...