The Journal of antibiotics. 2024 Mar;77(3):189-192. doi: 10.1038/s41429-023-00695-y Q22.72025

Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13

来自放线菌Kitasatospora putterlickiae 10-13的新型抗生素生物合成前体precezomycin 翻译改进

Di Mao^{1 2}, Pengwei Yu¹, Naoya Shinzato³, Lei Zhang², Weiping Zheng¹, Shan Lu⁴, Hideaki Kakeya⁵

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¹ School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.

² Department of System Chemotherapy and Molecular Sciences, Division of Medicinal Frontier Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.

³ Tropical Biosphere Research Center, University of the Ryukyus, Okinawa, 903-0213, Japan.

⁴ School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China. lushan@ujs.edu.cn.

⁵ Department of System Chemotherapy and Molecular Sciences, Division of Medicinal Frontier Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan. scseigyo-hisyo@pharm.kyoto-u.ac.jp.

DOI: 10.1038/s41429-023-00695-y PMID: 38200162

摘要 Ai翻译

A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin (1), was isolated from culture broth of actinomycete Kitasatospora putterlickiae 10-13. The planar structure was determined by 1D/2D NMR and HR(ESI)MS data analyses, and the absolute configurations were established by TDDFT calculation of ECD spectra. Precezomycin (1) exhibited moderate antibacterial activity against gram-positive bacteria including Staphylococcus aureus and Bacillu... ...点击完成人机验证后继续浏览

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期刊名：Journal of antibiotics

缩写：J ANTIBIOT

ISSN：0021-8820

e-ISSN：1881-1469

IF/分区：2.7/Q2

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Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13

来自放线菌Kitasatospora putterlickiae 10-13的新型抗生素生物合成前体precezomycin 翻译改进

Synthesis and absolute configuration of demethyl (C-11) cezomycin

德米甲(C-11)塞索霉素的合成及绝对构型确定

Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882

棒曲霉素是通过CalC激活为酯类化合物，用于streptomyces chartreusis nrrl 3882中钙霉素产生的进一步合成步骤中的一种抗生素中间体

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp

来源于罕见放线菌Saccharothrix sp.的新型苯取代的10元大环内酯类化合物Saccharothriolides A-C

[Identification and analysis of an actinomycete strain suppressing Clavibacter michiganensis subsp, michiganensis]

一株抑制茄病镰刀菌的放线菌菌株的鉴定与分析

Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura

Nomimicin，一种新螺旋四氢萘类聚酮化合物，产生菌为诺神草属放线菌

Streptomyces lycii sp. nov., an endogenous actinomycete isolated from Lycium ruthenicum

赖氨酸链霉菌（ Streptomyces lycii ）新种 —— 从枸杞中分离出的一种共生放线菌

Biology of actinomycetes

放线菌的生物学

[Formation of new heptaenic nonaromatic antibiotic tbilimycin by the culture Act. chartreusis var. tbilisus]

产漆菌var.tbilisus产生新型七烯非芳族抗生素梯里斯丁素的研究