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The Journal of antibiotics. 2024 Mar;77(3):156-162. doi: 10.1038/s41429-023-00696-x Q22.72025

Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499

深海真菌Scedosporium apiospermum FKJ-0499产生的酪醇茋及其新类似物对耳念珠菌临床分离株的抗真菌谱研究 翻译改进

Haruki Azami  1, Yoshihiro Watanabe  1  2, Kazunari Sakai  3, Hiroki Nakahara  1, Hiroki Kojima  1  2, Toshiyuki Tokiwa  2, Kenichi Nonaka  1  2, Yoshihiko Noguchi  1  2, Yuriko Nagano  4, Tomoyasu Hirose  1  2, Toshiaki Sunazuka  1  2, Hidehito Matsui  1  2, Naoaki Arima  3, Kazutoyo Abe  3, Hideaki Hanaki  1  2  3, Masato Iwatsuki  5  6

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作者单位

  • 1 Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 2 Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • 3 Tokyo New Drug Research Laboratories, Pharmaceutical Business Unit, Kowa Company, Ltd., 2-17-43 Noguchicho, Higashimurayama, Tokyo, 189-0022, Japan.
  • 4 Marine Biodiversity and Environmental Assessment Research Center, Research Institute for Global Change (RIGC), Japan Agency for Marine-Earth Science and Technology, 2-15 Natsushima-cho, Yokosuka, Kanagawa, 237-0061, Japan.
  • 5 Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.
  • 6 Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.

    • DOI: 10.1038/s41429-023-00696-x PMID: 38200163

    摘要 Ai翻译

    A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2). The structure of 1 was elucidated as a new analog of 2 by MS and NMR analyses. The absolute configuration of 1 was determined by chemical derivatization. Both compounds showed potent in vitro antifungal activity again... ...点击完成人机验证后继续浏览
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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499