An in vitro model of bleomycin-induced epithelial injury using stem cell-derived alveolar type 2 epithelial cells [0.03%]
利用干细胞衍生的II型肺泡上皮细胞建立博莱霉素诱导的上皮损伤体外模型
Yubin Han,Ha Ryong Kim,Jun Woo Kim et al.
Yubin Han et al.
Human alveoli constitute most of the lung parenchyma and play a pivotal role in respiratory diseases. Traditional alveolar type 2 epithelial cells, such as A549 and H441, have been widely used to study pulmonary toxicity mechanisms. However...
Tripchlorolide-induced reversible impairment of male fertility and the involvement of PI3K/Akt/mTOR signaling [0.03%]
三氯化物诱导的可逆性雄性不育及PI3K/Akt/mTOR信号途径的参与
Lele Zhou,Lingbin Chen,Cailin Zheng et al.
Lele Zhou et al.
Tripchlorolide, a low-toxicity derivative of the natural product triptolide, exhibits significant therapeutic potential for inflammatory and autoimmune diseases; however, its profile of male reproductive toxicity remains a major concern for...
Advances in aluminum oxide nanoparticles-induced neurotoxicity: CNS translocation, phenotypic outcomes, and mechanistic insights [0.03%]
先进氧化铝纳米粒子诱导的神经毒性进展：中枢神经系统转运、表型结果和机制见解
Lei Yu,Mohammad Nasiruddin Rana,Changjian Quan et al.
Lei Yu et al.
Aluminum oxide nanoparticles (Al2O3 NPs) exhibit remarkable physicochemical properties, making them essential for many applications such as high-temperature refractory materials, catalysis, biomedical uses, and environmental remediation. Th...
Artificial intelligence revolution in toxicology: Clinical precision, global equity, and the 2030 roadmap [0.03%]
毒理学领域的人工智能革命：临床精准性、全球公平性和2030年路线图
Jose L Domingo
Jose L Domingo
Artificial intelligence (AI) is transforming toxicology by enabling faster, more accurate, and more equitable approaches to diagnosis, treatment, research, and education. This review synthesizes recent advances in AI applications across cli...
Thallium: An Overview of Its Distribution in the Environment and Its Cellular and Molecular Toxicity [0.03%]
铊：其环境分布及其细胞和分子毒性的综述
Alexandre Varão Moura,Lucas Aleixo Leal Pedroza,José Domingos Santo da Silva et al.
Alexandre Varão Moura et al.
Thallium (Tl), a rare but highly toxic trace metal, poses significant environmental and health risks due to its increasing industrial applications and potential for contamination. This narrative review focuses on Tl's presence in soil and i...
Hepatobiliary Clearance of a Long and Thick Carbon Nanotube following Pulmonary Exposure in Mice [0.03%]
小鼠经肺暴露长而厚的碳纳米管后的肝胆清除率
Mathilde Sundberg,Trine Berthing,Pernille Høgh Danielsen et al.
Mathilde Sundberg et al.
Long and thick carbon nanotubes (CNTs), such as Mitsui-7, can translocate from the lungs to secondary organs, including the liver, following pulmonary exposure. Although Mitsui-7 CNT is biopersistent, previous studies have suggested clearan...
Exposure to welding fumes and health effects: A systematic evaluation based on human biomonitoring analyses [0.03%]
焊接烟雾暴露与健康效应：基于人体生物监测分析的系统评估
Amir Hossein Khoshakhlagh,Safiye Ghobakhloo,Ulla Birgitte Vogel et al.
Amir Hossein Khoshakhlagh et al.
Background: Occupational exposure to heavy metals (HMs) through inhalation of welding emissions presents a serious health hazard to welders. This systematic review aimed to evaluate the concentrations of HMs in biological...
Excessive fluoride induces renal cell apoptosis and subsequent renal dysfunction [0.03%]
过量的氟导致肾细胞凋亡及后续的肾功能障碍
Yi Zhang,Zhao Xu,Pengpeng Xie et al.
Yi Zhang et al.
This study investigated the mechanisms of renal injury and dysfunction induced by chronic excessive fluoride exposure. Sixty female Sprague-Dawley rats were administered sodium fluoride (NaF) at 0, 50, 100, or 150 mg/L in drinking water for...
Histone H3K4 monomethyltransferase SETD7 promoted osteogenic differentiation of bone marrow mesenchymal stem cells exposed to Hydroquinone via autophagy [0.03%]
组蛋白H3K4单甲基转移酶SETD7通过自噬促进对苯二酚诱导的骨髓间充质干细胞成骨分化
Yilin Shen,Yibo Niu,Tao Xu et al.
Yilin Shen et al.
Hydroquinone (HQ), a major metabolite of benzene, is a recognized risk factor for acute myeloid leukemia (AML). However, the mechanisms underlying HQ-associated leukaemogenesis remain incompletely understood. Increasing evidence suggests th...
Identification of xenobiotics interfering with 5α-reductase (SRD5A2) activity [0.03%]
异源分子干扰5α-还原酶(SRD5A2)活性的识别
Jacek Kędzierski,Rianne E van Diest,Julien A Allard et al.
Jacek Kędzierski et al.
5α-Dihydroxytestosterone (DHT) is essential for male sexual development, and its synthesis from testosterone is mediated by the steroid 5α-reductase (SRD5A) isoenzymes, SRD5A1 and SRD5A2. SRD5A2 is the predominant isoform expressed in rep...