Tobacco exposure induces T cell exhaustion and dysregulated interactions with epithelial cells in the tumor microenvironment of esophageal squamous cell carcinoma [0.03%]
烟草暴露诱导食管鳞癌肿瘤微环境中的T细胞衰竭及与上皮细胞相互作用失调
Yueting Zhou,Yikai Ma,Kexin Cao et al.
Yueting Zhou et al.
Smoking is a well-established risk factor for esophageal squamous cell carcinoma (ESCC), yet its impact on the tumor microenvironment (TME) remains incompletely understood. Using single-cell RNA sequencing of ESCC samples, we identified dis...
High-throughput toxicological assessment of heated tobacco product aerosols using RNA sequencing-based concentration-response modeling [0.03%]
基于RNA测序的浓度响应模型在评估加热不燃烧烟草产品的毒性中的应用
Kazushi Matsumura
Kazushi Matsumura
Heated tobacco products (HTPs) operate without combustion and are designed to reduce exposure to harmful constituents compared to cigarettes. Within the HTP category, rapid consumer-led technological development has resulted in a growing di...
Sulfur Mustard-Induced Acute Lung Injury: Mechanistic Insights into Oxidative Stress and Inflammatory Response Interactions [0.03%]
芥子气诱导的急性肺损伤：氧化应激和炎症反应相互作用的机制研究
Zifeng Deng,Minjie Shi,Zhengyuan Zhao et al.
Zifeng Deng et al.
Sulfur mustard (SM), a highly toxic vesicant chemical warfare agent, can induce severe acute lung injury and poses a substantial threat to human health. Oxidative stress and inflammatory responses play central roles in the pathogenesis of S...
Effects of microplastics and nanoplastics on rodent gut microbiota diversity: A systematic review and meta-analysis [0.03%]
微塑料和纳米塑料对啮齿动物肠道微生物群多样性的影响：系统评价和Meta分析
Asmaa Lafram,Omaima Mouiret,Yahya Al Naggar et al.
Asmaa Lafram et al.
The increasing presence of microplastics (MPs) and nanoplastics (NPs) in food and water has raised concerns about their potential effects on gut microbiota. This study provides a comprehensive synthesis through a systematic review and meta-...
Predictors of bisphenol A exposure in pregnant women of the Barwon Infant Study [0.03%]
巴威恩婴儿研究中影响孕妇双酚A暴露的因素分析
Eva J Sugeng,Sarah Thomson,James Hedley et al.
Eva J Sugeng et al.
Bisphenol-A (BPA) is a widely used chemical used in plastic and an endocrine disruptor ubiquitous in most developed settings. Exposure, particularly in early life, is implicated in a range of negative health outcomes. This study assessed wh...
Fenazaquin impairs liver development and metabolic homeostasis in zebrafish (Danio rerio) by disrupting glucose and lipid metabolism [0.03%]
氟尼脲通过干扰糖脂代谢扰乱斑马鱼（Danio rerio）肝发育和代谢稳态
Jingwen Chen,Lin Gao,Hanbing Hao et al.
Jingwen Chen et al.
Fenazaquin (FEN) is an emerging low-dose acaricide used for mite control in vegetable crops. It is potential to enter aquatic environments via runoff, yet studies on its toxicity to aquatic organisms remain limited. This study aims to asses...
LEF1 regulated CTHRC1 promotes silica-induced pulmonary fibrosis through CD44-dependent signaling [0.03%]
LEF1调控的CTHRC1通过CD44依赖性信号促进硅尘诱导的肺纤维化
Ting Wang,Wenqing Sun,Qingyan Yang et al.
Ting Wang et al.
Silicosis is an incurable fibrotic lung disease caused by crystalline silica exposure. Aberrant activation of lung fibroblasts into pathological fibroblasts is a hallmark of silicosis. CTHRC1 has been considered a novel fibroblast activatio...
hERG channel blockade and additive interactions of magnolol and honokiol from Magnolia species [0.03%]
Magnoliaceae来源的没药素和异シ筒草素的HERG通道阻滞及协同作用研究
Wei Zhao,Tingting Hao,Hui Lu et al.
Wei Zhao et al.
The Magnolia officinalis cortex (the dried bark known as "Houpo") is widely used in traditional Chinese medicine (TCM). In this study, we discovered some potential off-target effects of M. officinalis due to the blocking effects on hERG (hu...
Evaluation of dose-dependent hematotoxic effects of celastrol on human blood cells in vitro [0.03%]
基于体外人血细胞模型评估雷公藤红素剂量依赖性骨髓毒性作用及机制研究
Gayathri Hemant,Kurnegala Manikanta,Somanathapura K NaveenKumar et al.
Gayathri Hemant et al.
Over the past two decades, celastrol has gained significant scientific interest due to its ability to inhibit NF-κB, STAT3, and NLRP3 signaling pathways, resulting in antiinflammatory, antioxidant, and anticancer effects in various rodent ...
Environmental pharmaceutical and antibiotic mixtures: An exposomics-guided framework for mechanistic toxicology [0.03%]
环境药物和抗生素混合物：一种基于暴露组学的机制毒理学框架
Muhammad Saeed Akhtar,Wajid Zaman
Muhammad Saeed Akhtar
Pharmaceuticals and antibiotics occur in the environment as complex, time-varying mixtures, but their toxicological interpretation remains limited by targeted chemical lists, parent-compound monitoring, and single-compound testing. This nar...