Is lychee-associated encephalopathy in children a straightforward case of toxicity or a complex metabolic and environmental cascade? [0.03%]
儿童荔枝相关脑病是单纯的毒性作用还是复杂的代谢和环境链反应？
Richa Soni,Santasabuj Das,Gopal Shankar Sahni et al.
Richa Soni et al.
Every year, annual outbreaks of AES occur in lychee-growing regions: previously healthy children suddenly succumb to Acute Encephalitis Syndrome (AES). Initial suspicions pointed towards the seemingly innocent lychee fruit and its inherent ...
Human serum albumin-adduct biomarkers to prove human poisoning with methanethiol [0.03%]
人甲基硫中毒的证明的人血清白蛋白加合生物标志物
Chenglong Zhang,Ruiqin Yang,Shuai Liu et al.
Chenglong Zhang et al.
Exposure to methanethiol (MT) presents a significant challenge in public healthcare and could be a concern in the context of terrorist attacks. Therefore, reliable verification procedures for MT intoxication are essential for forensic, toxi...
Geniposide induces hepatotoxicity via the bile acid-induced activation of NLRP3 inflammasome and regulation of the FXR/PERK/TXNIP pathway [0.03%]
金丝桃苷通过胆汁酸激活NLRP3炎性小体和FXR/PERK/TXNIP通路诱导肝毒性
Zhinan Jin,Shenghui Cheng,Baoyue Liu et al.
Zhinan Jin et al.
Gardenia jasminoides, as a widely used traditional Chinese medicine, excessive consumption of it may lead to severe liver injury. As the main hepatotoxic component in Gardenia jasminoides, the specific mechanism by which geniposide (GE) cau...
Challenges and Solutions in Measuring Commonly Used Biomarkers for Drug-Induced Liver Injury in a Liver-On-A-Chip Platform [0.03%]
基于肝脏芯片平台测量药物性肝损伤常用生物标志物的挑战与解决方案
Qiang Shi,Laura K Schnackenberg,Lijun Ren et al.
Qiang Shi et al.
Liver-on-a-chip (liver-chip) is designed to better maintain in vitro-cultured hepatic cells and improve the prediction of drug-induced liver injury (DILI). Albumin, urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and...
Toxicity of Humectants Propylene Glycol and Vegetable Glycerin in Electronic Nicotine Delivery Systems [0.03%]
电子尼古丁递送系统中溶剂丙二醇和植物甘油的毒性研究
Yehao Sun,Karen Lin,Felix Effah et al.
Yehao Sun et al.
Background: E-cigarettes and other electronic nicotine delivery systems (ENDs) remain a significant public health risk. Although deployed as tobacco smoking cessation tools, e-cigarettes have gained greater popularity amo...
Application of an in vitro reconstructed human skin coculture with THP-1 on cosmeticsthein skin sensitization [0.03%]
体外重建的人工皮肤与THP-1共培养在化妆品致皮肤过敏中的应用研究
Bo Wang,Hongyu Ma,Yuying Cheng et al.
Bo Wang et al.
Background: Sensitivity testing for cosmetic formulations mainly involves human patch tests. Cell models, including KeratinoSensTM, ARE-Nrf2 luciferase LuSens and h-CLAT, can predict chemical sensitization according to th...
Association between volatile organic compound exposure and elevated total immunoglobulin E: Risk factor screening in mixed exposure scenarios and potential biological mechanisms [0.03%]
挥发性有机化合物暴露与总免疫球蛋白E升高的关联：混合暴露情景下的危险因素筛选及潜在生物学机制探讨
Xianhao Wang,Xinyue Wang,Ruxu Yan et al.
Xianhao Wang et al.
Environmental pollutants are increasingly recognized as important modulators of immune function, yet the influence of volatile organic compound (VOC) exposure on immunoglobulin E (IgE) levels remains poorly characterized. Using data from th...
Bisphenol A Exposure Associates with Colorectal Cancer Metastasis and Immunosuppression: A Five-Year Cohort Study [0.03%]
双酚A暴露与结直肠癌转移和免疫抑制相关：一项五年队列研究
Xiaoming Shen,Chuanqing Bao
Xiaoming Shen
Background: Bisphenol A (BPA) is a widespread endocrine-disrupting chemical found in consumer products. While BPA exposure has been associated with various health risks, its specific impact on colorectal cancer (CRC) prog...
PFOA exposure causes kidney injury via disruption of lipid metabolism mediated by PPARα signaling pathway: An integrated analysis [0.03%]
全氟辛酸通过干扰PPARα信号通路介导的脂质代谢造成肾脏损伤：集成分析法研究
Yuanyuan Wu,Yuhong Jiang,Zhonghua Fan et al.
Yuanyuan Wu et al.
Perfluorooctanoic acid (PFOA) is a persistent organic pollutant (POP) that can accumulate in living organisms and cause damage to multiple organs and systems in the human body. The kidney is viewed as a key organ affected by PFOA, but the e...
Role of inflammatory response in benzo[a]pyrene-induced noradrenergic axon degeneration in mouse brain [0.03%]
炎症反应在脑内茋芳烃致去甲肾上腺素能轴索变性中的作用研究
Yousra Reda,Cai Zong,Akane Ikoma et al.
Yousra Reda et al.
Environmental pollution is a major contributor to neurotoxicity and could explain various nervous system dysfunctions. The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) is widely present in the environment, including air poll...